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4.5 Substance use and abuse  (Page 2/24)

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Four main drug categories are identified by differently colored circles showing overlaps: the four main drug categories are “antipsychotics,” “stimulants,” “depressants,” and “hallucinogens.” The circle titled “Antipsychotics” includes the drug names “Haldol,” “Risperdal,” and “Seroquel.” The circle titled “Stimulants” contains a subcircle titled “Psychmotor stimulants” with the drug names “Amphetamines,” “Khat,” “Ritalin,” and “Cocaine.” The “Stimulants” circle contains another subcircle titled “Methylxanthines” with the drug names “Caffeine,” “Theophylline,” and “Theobromine.” The circle titled “Depressants” contains a subcircle titled “Sedative Hypnotics” with the drug names “Alcohol,” “Barbituates,” “Ether,” and “GHB”; within that circle is a subcircle titled “Minor tranquilizers” with the drug names “Ativan,” “Valium,” and “Xanax.” “Nicotine” falls in the overlap between the “Stimulants” and “Depressants” circles. The circle titled “Depressants” also contains a subcircle titled “Narcotic Analgesics” with the drug names “Opium,” “Codeine,” “Morphine,” “Heroin,” and “DXM.” “DXM” falls in the overlap between the “Depressants” circle and the “Dissociatives” subcircle of the “Hallucinogens” circle. The circle titled “Hallucinogens” contains a subcircle labeled “Dissociatives” including the drug names ”Ketamine,” “PCP,” “Nitrous,” “Amanitas,” and “Salvinorum.” Within that subcircle, “Ketamine,” “PCP,” and “Nitrous” overlap with with the “depressants” circle The circle titled “Hallucinogens” also contains a subcircle titled “Psychadelics” including the drug names “MDMA,” “Mescaline,” “LSD,” “Psilocybin,” “AMT,” “DMT,” and “Ibogaine.” Within that subcircle, “MDMA,” “Mescaline,” “LSD,” “Psilocybin,” and “AMT” fall within the overlap between the “Hallucinogens” and “Stimulants” circles. “Ibogaine” falls within the overlap between the “Psychadelics” and “Dissociatives” subcircles. Outside of all subcircles, “Marijuana” falls within the overlap between the “Stimulants,” “Depressants,” and “Hallucinogens” circles.
This figure illustrates various drug categories and overlap among them. (credit: modification of work by Derrick Snider)

Alcohol and other depressants

Ethanol, which we commonly refer to as alcohol, is in a class of psychoactive drugs known as depressants ( [link] ). A depressant    is a drug that tends to suppress central nervous system activity. Other depressants include barbiturates and benzodiazepines. These drugs share in common their ability to serve as agonists of the gamma-Aminobutyric acid (GABA) neurotransmitter system. Because GABA has a quieting effect on the brain, GABA agonists also have a quieting effect; these types of drugs are often prescribed to treat both anxiety and insomnia.

An illustration of a GABA-gated chloride channel in a cell membrane shows receptor sites for barbiturate, benzodiazepine, GABA, alcohol, and neurosteroids, as well as three negatively-charged chloride ions passing through the channel. Each drug type has a specific shape, such as triangular, rectangular or square, which corresponds to a similarly shaped receptor spot.
The GABA-gated chloride (Cl-) channel is embedded in the cell membrane of certain neurons. The channel has multiple receptor sites where alcohol, barbiturates, and benzodiazepines bind to exert their effects. The binding of these molecules opens the chloride channel, allowing negatively-charged chloride ions (Cl-) into the neuron's cell body. Changing its charge in a negative direction pushes the neuron away from firing; thus, activating a GABA neuron has a quieting effect on the brain.

Acute alcohol administration results in a variety of changes to consciousness. At rather low doses, alcohol use is associated with feelings of euphoria. As the dose increases, people report feeling sedated. Generally, alcohol is associated with decreases in reaction time and visual acuity, lowered levels of alertness, and reduction in behavioral control. With excessive alcohol use, a person might experience a complete loss of consciousness and/or difficulty remembering events that occurred during a period of intoxication (McKim&Hancock, 2013). In addition, if a pregnant woman consumes alcohol, her infant may be born with a cluster of birth defects and symptoms collectively called fetal alcohol spectrum disorder (FASD) or fetal alcohol syndrome (FAS).

With repeated use of many central nervous system depressants, such as alcohol, a person becomes physically dependent upon the substance and will exhibit signs of both tolerance and withdrawal. Psychological dependence on these drugs is also possible. Therefore, the abuse potential of central nervous system depressants is relatively high.

Drug withdrawal is usually an aversive experience, and it can be a life-threatening process in individuals who have a long history of very high doses of alcohol and/or barbiturates. This is of such concern that people who are trying to overcome addiction to these substances should only do so under medical supervision.

Stimulants

Stimulants are drugs that tend to increase overall levels of neural activity. Many of these drugs act as agonists of the dopamine neurotransmitter system. Dopamine activity is often associated with reward and craving; therefore, drugs that affect dopamine neurotransmission often have abuse liability. Drugs in this category include cocaine, amphetamines (including methamphetamine), cathinones (i.e., bath salts), MDMA (ecstasy), nicotine, and caffeine.

Questions & Answers

A golfer on a fairway is 70 m away from the green, which sits below the level of the fairway by 20 m. If the golfer hits the ball at an angle of 40° with an initial speed of 20 m/s, how close to the green does she come?
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cm
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A mouse of mass 200 g falls 100 m down a vertical mine shaft and lands at the bottom with a speed of 8.0 m/s. During its fall, how much work is done on the mouse by air resistance
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Chemistry is a branch of science that deals with the study of matter,it composition,it structure and the changes it undergoes
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A ball is thrown straight up.it passes a 2.0m high window 7.50 m off the ground on it path up and takes 1.30 s to go past the window.what was the ball initial velocity
Krampah Reply
2. A sled plus passenger with total mass 50 kg is pulled 20 m across the snow (0.20) at constant velocity by a force directed 25° above the horizontal. Calculate (a) the work of the applied force, (b) the work of friction, and (c) the total work.
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you have been hired as an espert witness in a court case involving an automobile accident. the accident involved car A of mass 1500kg which crashed into stationary car B of mass 1100kg. the driver of car A applied his brakes 15 m before he skidded and crashed into car B. after the collision, car A s
Samuel Reply
can someone explain to me, an ignorant high school student, why the trend of the graph doesn't follow the fact that the higher frequency a sound wave is, the more power it is, hence, making me think the phons output would follow this general trend?
Joseph Reply
Nevermind i just realied that the graph is the phons output for a person with normal hearing and not just the phons output of the sound waves power, I should read the entire thing next time
Joseph
Follow up question, does anyone know where I can find a graph that accuretly depicts the actual relative "power" output of sound over its frequency instead of just humans hearing
Joseph
"Generation of electrical energy from sound energy | IEEE Conference Publication | IEEE Xplore" ***ieeexplore.ieee.org/document/7150687?reload=true
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Magreth
progressive wave
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Mujahid
A string is 3.00 m long with a mass of 5.00 g. The string is held taut with a tension of 500.00 N applied to the string. A pulse is sent down the string. How long does it take the pulse to travel the 3.00 m of the string?
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Source:  OpenStax, Psychology. OpenStax CNX. Feb 03, 2015 Download for free at https://legacy.cnx.org/content/col11629/1.5
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