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Risk factors for bipolar disorder

Bipolar disorder is considerably less frequent than major depressive disorder. In the United States, 1 out of every 167 people meets the criteria for bipolar disorder each year, and 1 out of 100 meet the criteria within their lifetime (Merikangas et al., 2011). The rates are higher in men than in women, and about half of those with this disorder report onset before the age of 25 (Merikangas et al., 2011). Around 90% of those with bipolar disorder have a comorbid disorder, most often an anxiety disorder or a substance abuse problem. Unfortunately, close to half of the people suffering from bipolar disorder do not receive treatment (Merikangas&Tohen, 2011). Suicide rates are extremely high among those with bipolar disorder: around 36% of individuals with this disorder attempt suicide at least once in their lifetime (Novick, Swartz,&Frank, 2010), and between 15%–19% complete suicide (Newman, 2004).

The biological basis of mood disorders

Mood disorders have been shown to have a strong genetic and biological basis. Relatives of those with major depressive disorder have double the risk of developing major depressive disorder, whereas relatives of patients with bipolar disorder have over nine times the risk (Merikangas et al., 2011). The rate of concordance for major depressive disorder is higher among identical twins than fraternal twins (50% vs. 38%, respectively), as is that of bipolar disorder (67% vs. 16%, respectively), suggesting that genetic factors play a stronger role in bipolar disorder than in major depressive disorder (Merikangas et al. 2011).

People with mood disorders often have imbalances in certain neurotransmitters, particularly norepinephrine and serotonin (Thase, 2009). These neurotransmitters are important regulators of the bodily functions that are disrupted in mood disorders, including appetite, sex drive, sleep, arousal, and mood. Medications that are used to treat major depressive disorder typically boost serotonin and norepinephrine activity, whereas lithium—used in the treatment of bipolar disorder—blocks norepinephrine activity at the synapses ( [link] ).

An illustration shows the synaptic space between two neurons with neurotransmitters being released into the synapse and attaching to receptors.
Many medications designed to treat mood disorders work by altering neurotransmitter activity in the neural synapse.

Depression is linked to abnormal activity in several regions of the brain (Fitzgerald, Laird, Maller,&Daskalakis, 2008) including those important in assessing the emotional significance of stimuli and experiencing emotions (amygdala), and in regulating and controlling emotions (like the prefrontal cortex, or PFC) (LeMoult, Castonguay, Joormann,&McAleavey, 2013). Depressed individuals show elevated amygdala activity (Drevets, Bogers,&Raichle, 2002), especially when presented with negative emotional stimuli, such as photos of sad faces ( [link] ) (Surguladze et al., 2005). Interestingly, heightened amygdala activation to negative emotional stimuli among depressed persons occurs even when stimuli are presented outside of conscious awareness (Victor, Furey, Fromm, Öhman,&Drevets, 2010), and it persists even after the negative emotional stimuli are no longer present (Siegle, Thompson, Carter, Steinhauer,&Thase, 2007). Additionally, depressed individuals exhibit less activation in the prefrontal, particularly on the left side (Davidson, Pizzagalli,&Nitschke, 2009). Because the PFC can dampen amygdala activation, thereby enabling one to suppress negative emotions (Phan et al., 2005), decreased activation in certain regions of the PFC may inhibit its ability to override negative emotions that might then lead to more negative mood states (Davidson et al., 2009). These findings suggest that depressed persons are more prone to react to emotionally negative stimuli, yet have greater difficulty controlling these reactions.

Questions & Answers

what is mood
Abdi Reply
mood is an affective state. In contrast to emotions or feelings, moods are less specific, less intense and less likely to be provoked or instantiated by a particular stimulus or event
la
Why some woman are looking up and down why you approach her?
Ridwan Reply
I don't know
GOPAL
It could be a sign of either lack of interest or maybe they are nervous.
Rachna
if a girl don't look directly in your eyes while talking then it is 80 percent sure that she has crush on you
Sanket
or she is scared. fear creates an avoidant-type relationship. as does embarrassment. when a woman is so bold to look you in the eye, or other visual signs of her attention, she is performing a feminine courtship
but all this is also confirmed or denied by cultural background. in some countries women would be frowned on for approaching the man in any form. some societies hold women in highest regard, and thus their judgment is considered an honor.
not looking in the eye, is a sign if a female going through the development of a crush on the person OR that her past experiences and trauma compels her to avoid eye-contact. usually females do act nervous around the men they like but once there is an establishment of comfortness and trust
Tiasha
using myself as an example: if im interested, you will know it by my focus, my curiosity, my desire to know more. much like an interrogation i suppose. every question would ripple through you demanding an answer. then progressing onward. if im not interested, i would find some way out
looking into the eyes is just a matter of time
Tiasha
It is some sort of inhibition and/or trait of famininity.
dcs
if the woman is not interested in you in any way, that is when best she'll look up straight to your eyeballs, but if a woman is actually looking up and down while you ask her out or on a date, believe me, she never believed you in person can ask her out, maybe she feels you are too big to ask her ou
Olaleye
and if you are dressed in a way that is different to the onlooker, of course they are going to examine you. First to discover the apparent trend you are wearing, second to determine if you are foreign or mentally compromised. wink at them and blow a kiss next time. you may get a smile or rejection
if a woman does this to the man she is already dating, it relates to socioeconomical status concerns. "does my man look the part?" "will he make me look foolish among my peers?"
or simply "is he wearing the shoes i recommended?"
its not only happened to women, mens also perceive. mostly shy people feels this often. when shy people makes conversation with opposite genders, the main thinking of their is mostly there deal with opposite gender, its leads to shy and discomfort and makes them avoided straight look
gokul
the eyes are considered soul-bearing. to stay disconnected from sharing that part of yourself says many things, usually fear or discomfort. perhaps inferiority complex. or simply shyness as mentioned by gokul
May be she is Practical Minded. Gold Digger ? Because those type people Frequently look Top to Bottom to Analyse a Persons worth. The Best way to Judge is 1) She Holds an iPhone (just to look Posh) 2) She has a Cringy Behavior While Talking. (doesn't have a cultured attitude)
Mushtaque
if those two parameters match in any Girl. Then Money Speaks to her. Money in sense any form (Gift's / Phone's / Jewellery etc) Check Wisely and Approach Anyone Buddy. Take Care.
Mushtaque
very good Mushtaque. Her arrogant behavior or desire for flashy and valuable items would be signs of this. How would you handle this type of person if you were caught on conversation?
Being a Psychologist, I would look at her as a Subject and Have Conversation and know better about her and her intentions and why and what made her become like that. Hopefully not a One Day Task. In General as a Human, I would just Ignore.
Mushtaque
Mushtaque don't you think a psychologist is not supposed to judge a person? As far as I can see from your above messages you have already come to a conclusion that these are going to be her intentions. As a psychologist, should not you know that humans are complex and every individual differs?
Alisha
In this way you're Judging Psychologist's that they Cant Judge. hmmm. well, ofcourse they are Complex , but Traits are identifiable.
Mushtaque
a part of psychology is on human behavior which as well all know is variable. so, being a psychologist do you think an individual can be confined to first impressions?
Alisha
being psychologist is about being open minded and looking not judging as no individual is the same plus it's about digging deeper into the reasons behind the actions of certain individuals
Rhian
could not be put into better words, rhian.
Alisha
Agree with you Thomas.
Mushtaque
hi 👋
kim
Application Error, Shown Rhian name as Rhian Thomas. previous comment was for Rhian.
Mushtaque
I need help please
kim
Hi Kim Liza. May I know What Kind of Help you are seeking ?
Mushtaque
I have a talk in humanistic psychology I don't know what to do
kim
i seems not to understand your question please, can you enlighten us on it so as to contribute or proffer solution to it
Olaleye
you have to make a presentation that talks about humanistic psychology
kim
I made an introduction
kim
can u help me
kim
Humanistic Psychology: It is a psychological perspective that emphasizes the study of the whole person. Humanistic psychologists look at human behavior not only through the eyes of the observer, but through the eyes of the person doing the behaving.
Olaleye
Proponents of Humanistic Psychology Abraham Maslow Co-Founder of Humanistic Psychology with Carl Rogers Believed we are all biologically driven to achieve self- actualization Came up with Hierarchy of Needs theory that is most important humanistic theory.
Olaleye
thank you so much
kim
Proponents of Humanistic Psychology Abraham Maslow  Co-Founder of Humanistic Psychology with Carl Rogers  Believed we are all biologically driven to achieve self- actualization  Came up with Hierarchy of Needs theory that is most important humanistic theory.
Olaleye
Maslow is known for his Hierarchy of Needs • Maslow proposed 5 levels of need: from basic to more advanced, they are: – Physiological (food, water, sex) – Safety (security, order, stability – Belongingness and love – Esteem (from self and others) – Self-actualization • The more bas
Olaleye
According to Carl Rogers • Important issues must be defined by the individual: importance of an autonomous self: self-insight is what predicts later behavior. • Actualizing tendency: people tend to develop in a positive direction, toward self-actualization
Olaleye
• The way we perceive our environment determines how it affects us. (Roger's theory emphasizes phenomenology) • Incongruence between our self-concept and our experience leads to pathology
Olaleye
In Rogerian therapy, the client • Moves from talking about externals to talking about personal issues • Moves from talking about the past to dealing with the present • Becomes closer to and more comfortable with his/her feelings
Olaleye
• Becomes more open to new experiences, experiences more freedom
Olaleye
The Fully Functioning Person, for Rogers • Is aware of all experiences • Lives in the moment • Trusts in his/her self • Experiences freedom in choices • Is creative and adapts well • Is still growing and experiencing difficulties
Olaleye
i hope you will find this helpful
Olaleye
yeaaa thank you so much
kim
hey Guy's
Joseph
what's the difference between hallucinations and being crazy?
Joseph
they are both abnormalities
Olaleye
false perception in the absence of stimulus is hallucination.
dcs
crazy is a regular word using in daily life, which is passoinated towards objects or creatures.
dcs
Is/did anyone study/ing forensic psychology
AUDREIGH
please explain acquisition of skills
oshin
thanks everyone
Gimba
Acquisition Skill is the stage during which a new response is learned and gradually strengthened. For instance, Hitting moving objects, Horse riding, car driving etc,.
dcs
start a new thread for acquisition of skills
sumitra
what is the last stage of experimental method
sawera Reply
the thing which are used to verify hypotheses in experimental method it is called
sawera
Hi.. I'm unable to open the chat.. how do I do that.. please help!
sumitra Reply
español traducir en español ya
Rafael Reply
I'm sure if you went to settings you would be able to change the language.
Demi
안 데여. 한번도 못 찾았어요.
Lex
그런데 여기서 미국 사람들이 우리가 영화 쓰는 거는 그렇게 시킨 거야.
Lex
내가 뭐 물어 볼까 봐 그냥 이거 뭐라고
Lex
it's not speaking nonsense cuz you know it is basically nonsense the machine doesn't really hear what I'm saying cuz I can speak English as well. easier to take direction when you say Jolly Good, Tally Ho. God save the Queen for me.Pro Deo et Patriae And other snazzy cliches.Irrumatus Manducare US
Lex
anglo wasp POS
Lex
cave dwelling trogledite.
Lex
forgive my spelling.
Lex
what r u doing
ANGELICA
what's actually going on here?
Demi
ok
ANGELICA
take it easy
King
are you guys studying or working
King
I'm studying, what are you?
Demi
im studying
ANGELICA
are you enjoying it angelica?
Demi
this year, I'm going to take Rpm
King
hoping to pass the exam
King
studying what?
King
I'm studying clinical. good luck with your exams!
Demi
Thanks Demi.
King
hi
Sharavana
hello., how are you
King
I wonder why this app don't have information about statistics
King
that's a very good point. I've found the app very helpful for my introduction into my new career path so I'm more than great full
Demi
I hope to find app like yours
King
this subject I need to review: Psychological Assessment, Theories of Personality, Abnormal Psychology and Industrial Psychology.., I need to refresh my mind even though I'm a fresh Graduate of Bs Psychology.
King
food in classical condition is called
dude Reply
dream anylisis is method of
dude
dream anylisis is method of
dude
psychoanalysis
Kaiser
food is unconditioned stimulus
gokul
it's a necessity
Anthony
its unconditional stimulus
Puja
Unconditional Stimulus
dcs
conditioned stimulus
Laura
classical conditioning
JADE
advantages of ECG in biopsychology
Sheeba Reply
can I get the information about the advantages of ECG in biopsychology
Sheeba
what do you call that moment right before the "emotion (s)" take place? that blink of an eye flash because that is how I I experience being a person with schizophrenia...?
Stepphun Reply
at childhood, focus is upon what?
Oliver Reply
It shld be on their developmental stages!! Oliver. From cognitive to kinesthetic, intrapersonal to interpersonal, fine motor to gross motor, n strong reasoning skills etc.
Smitha
Check the works of Jean Piaget n Erick Erickson's stages of developments, will be helpful.
Smitha
Child develops in all the biopsychosocial ways, and all the developments at that time are crucial. From biological perspective, neural development and sensory and motor abilities psychological perspective: various cognitive processes develop Social aspect focus on development of various relations.
Pranav
define knowledge and compare it with learning
lidsay Reply
Is learning a cognitive behaviour?
sumitra Reply
Its the ability to act instinctly
lidsay
is there motivation in cognitive thinking and behaviour?
Stepphun Reply
what is fear appeal
Takdees Reply
manovijan ka tisara bal kya hai
Pawan Reply
what is psychology
Chhaya Reply
Psychological Testing and Statistics-I
Chhaya
psychology is the scientific study of human & animal behaviour & their cognitive processes
Arnika

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Source:  OpenStax, Psychology. OpenStax CNX. Feb 03, 2015 Download for free at https://legacy.cnx.org/content/col11629/1.5
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