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Diagnostic uses of radiopharmaceuticals
Procedure, Isotope Activity (mCi), where 1 mCi = 3.7 × 10 7 Bq Procedure, Isotope Activity (mCi), where 1 mCi = 3.7 × 10 7 Bq
Brain scan Thyroid scan
99m Tc 7.5 131 I 0.05
15 O (PET) 50 123 I 0.07
Lung scan Liver scan
13 Xe 7.5 198 Au (colloid) 0.1
99m Tc 2 99m Tc (colloid) 2
Cardiovascular blood pool Bone scan
131 I 0.2 85 Sr 0.1
99m Tc 2 99m Tc 10
Cardiovascular arterial flow Kidney scan
201 Tl 3 197 Hg 0.1
24 Na 7.5 99m Tc 1.5

The first radiation detectors produced two-dimensional images, like a photo taken from a camera. However, a circular array of detectors that can be rotated can be used to produce three-dimensional images. This technique is similar to that used in X-ray computed tomography (CT) scans. One application of this technique is called single-photon-emission CT (SPECT) ( [link] ). The spatial resolution of this technique is about 1 cm.

A photograph of a person lying in an imaging machine.
The SPECT machine uses radiopharmaceutical compounds to produce an image of the human body. The machine takes advantage of the physics of nuclear beat decays and electron-positron collisions. (credit: “Woldo”/Wikimedia Commons)

Improved image resolution is achieved by a technique known as positron emission tomography (PET)    . This technique use radioisotopes that decay by β + radiation. When a positron encounters an electron, these particle annihilate to produce two gamma-ray photons. This reaction is represented by

e + + e 2 γ .

These γ -ray photons have identical 0.511-MeV energies and move directly away from one another ( [link] ). This easily identified decay signature can be used to identify the location of the radioactive isotope. Examples of β + -emitting isotopes used in PET include 11 C , 13 N , 15 O , and 18 F . The nuclei have the advantage of being able to function as tags for natural body compounds. Its resolution of 0.5 cm is better than that of SPECT.

The figure of a person lying with his head within a circular chamber. Two rays labeled gamma radiate outwards from his head. Their point of origin is labeled e positive plus e negative annihilation.
A PET system takes advantage of the two identical γ -ray photons produced by positron-electron annihilation. These γ rays are emitted in opposite directions, so that the line along which each pair is emitted is determined.

PET scans are especially useful to examine the brain’s anatomy and function. For example, PET scans can be used to monitor the brain’s use of oxygen and water, identify regions of decreased metabolism (linked to Alzheimer’s disease), and locate different parts of the brain responsible for sight, speech, and fine motor activity

Is it a tumor? View an animation of simplified magnetic resonance imaging (MRI) to see if you can tell. Your head is full of tiny radio transmitters (the nuclear spins of the hydrogen nuclei of your water molecules). In an MRI unit, these little radios can be made to broadcast their positions, giving a detailed picture of the inside of your head.

Biological effects

Nuclear radiation can have both positive and negative effects on biological systems. However, it can also be used to treat and even cure cancer. How do we understand these effects? To answer this question, consider molecules within cells, particularly DNA molecules.

Cells have long, double-helical DNA molecules containing chemical codes that govern the function and processes of the cell. Nuclear radiation can alter the structural features of the DNA chain, leading to changes in the genetic code. In human cells, we can have as many as a million individual instances of damage to DNA per cell per day. DNA contains codes that check whether the DNA is damaged and can repair itself. This repair ability of DNA is vital for maintaining the integrity of the genetic code and for the normal functioning of the entire organism. It should be constantly active and needs to respond rapidly. The rate of DNA repair depends on various factors such as the type and age of the cell. If nuclear radiation damages the ability of the cell to repair DNA, the cell can

Questions & Answers

what is bohrs model for hydrogen atom
Swagatika Reply
hi
Tr
Hello
Youte
Hi
Nwangwu-ike
hi
Siddiquee
what is the value of speed of light
Propessor Reply
1.79×10_¹⁹ km per hour
Swagatika
what r dwarf planet
Sivalakshmi Reply
what is energy
Isiguzo Reply
কাজের একক কী
Jasim
কাজের একক কী
Jasim
friction ka direction Kaise pata karte hai
Rahul Reply
friction is always in the opposite of the direction of moving object
Punia
A twin paradox in the special theory of relativity arises due to.....? a) asymmetric of time only b) symmetric of time only c) only time
Varia Reply
b) symmetric of time only
Swagatika
fundamental note of a vibrating string
fasoyin Reply
every matter made up of particles and particles are also subdivided which are themselves subdivided and so on ,and the basic and smallest smallest smallest division is energy which vibrates to become particles and thats why particles have wave nature
Alvin
what are matter waves? Give some examples
mallam Reply
according to de Broglie any matter particles by attaining the higher velocity as compared to light'ill show the wave nature and equation of wave will applicable on it but in practical life people see it is impossible however it is practicaly true and possible while looking at the earth matter at far
Manikant
a centeral part of theory of quantum mechanics example:just like a beam of light or a water wave
Swagatika
Mathematical expression of principle of relativity
Nasir Reply
given that the velocity v of wave depends on the tension f in the spring, it's length 'I' and it's mass 'm'. derive using dimension the equation of the wave
obia Reply
What is the importance of de-broglie's wavelength?
Mukulika Reply
he related wave to matter
Zahid
at subatomic level wave and matter are associated. this refering to mass energy equivalence
Zahid
it is key of quantum
Manikant
how those weight effect a stable motion at equilibrium
Nonso Reply
how do I differentiate this equation- A sinwt with respect to t
Evans Reply
just use the chain rule : let u =wt , the dy/dt = dy/du × du/dt : wA × cos(wt)
Jerry
I see my message got garbled , anyway use the chain rule with u= wt , etc...
Jerry
de broglie wave equation
LoNE Reply
vy beautiful equation
chandrasekhar
what is electro statics
fitsum Reply
when you consider systems consisting of fixed charges
Sherly
hi ma new
adam
hello
Amal

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Source:  OpenStax, University physics volume 3. OpenStax CNX. Nov 04, 2016 Download for free at http://cnx.org/content/col12067/1.4
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