22.11 More applications of magnetism  (Page 2/12)

Magnetic resonance imaging

Magnetic resonance imaging (MRI) is one of the most useful and rapidly growing medical imaging tools. It non-invasively produces two-dimensional and three-dimensional images of the body that provide important medical information with none of the hazards of x-rays. MRI is based on an effect called nuclear magnetic resonance (NMR)    in which an externally applied magnetic field interacts with the nuclei of certain atoms, particularly those of hydrogen (protons). These nuclei possess their own small magnetic fields, similar to those of electrons and the current loops discussed earlier in this chapter.

When placed in an external magnetic field, such nuclei experience a torque that pushes or aligns the nuclei into one of two new energy states—depending on the orientation of its spin (analogous to the N pole and S pole in a bar magnet). Transitions from the lower to higher energy state can be achieved by using an external radio frequency signal to “flip” the orientation of the small magnets. (This is actually a quantum mechanical process. The direction of the nuclear magnetic field is quantized as is energy in the radio waves. We will return to these topics in later chapters.) The specific frequency of the radio waves that are absorbed and reemitted depends sensitively on the type of nucleus, the chemical environment, and the external magnetic field strength. Therefore, this is a resonance phenomenon in which nuclei in a magnetic field act like resonators (analogous to those discussed in the treatment of sound in Oscillatory Motion and Waves ) that absorb and reemit only certain frequencies. Hence, the phenomenon is named nuclear magnetic resonance (NMR).

NMR has been used for more than 50 years as an analytical tool. It was formulated in 1946 by F. Bloch and E. Purcell, with the 1952 Nobel Prize in Physics going to them for their work. Over the past two decades, NMR has been developed to produce detailed images in a process now called magnetic resonance imaging (MRI), a name coined to avoid the use of the word “nuclear” and the concomitant implication that nuclear radiation is involved. (It is not.) The 2003 Nobel Prize in Medicine went to P. Lauterbur and P. Mansfield for their work with MRI applications.

The largest part of the MRI unit is a superconducting magnet that creates a magnetic field, typically between 1 and 2 T in strength, over a relatively large volume. MRI images can be both highly detailed and informative about structures and organ functions. It is helpful that normal and non-normal tissues respond differently for slight changes in the magnetic field. In most medical images, the protons that are hydrogen nuclei are imaged. (About 2/3 of the atoms in the body are hydrogen.) Their location and density give a variety of medically useful information, such as organ function, the condition of tissue (as in the brain), and the shape of structures, such as vertebral disks and knee-joint surfaces. MRI can also be used to follow the movement of certain ions across membranes, yielding information on active transport, osmosis, dialysis, and other phenomena. With excellent spatial resolution, MRI can provide information about tumors, strokes, shoulder injuries, infections, etc.