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  • Explain the concept of radiotherapy and list typical doses for cancer therapy.

Therapeutic applications of ionizing radiation, called radiation therapy or radiotherapy    , have existed since the discovery of x-rays and nuclear radioactivity. Today, radiotherapy is used almost exclusively for cancer therapy, where it saves thousands of lives and improves the quality of life and longevity of many it cannot save. Radiotherapy may be used alone or in combination with surgery and chemotherapy (drug treatment) depending on the type of cancer and the response of the patient. A careful examination of all available data has established that radiotherapy’s beneficial effects far outweigh its long-term risks.

Medical application

The earliest uses of ionizing radiation on humans were mostly harmful, with many at the level of snake oil as seen in [link] . Radium-doped cosmetics that glowed in the dark were used around the time of World War I. As recently as the 1950s, radon mine tours were promoted as healthful and rejuvenating—those who toured were exposed but gained no benefits. Radium salts were sold as health elixirs for many years. The gruesome death of a wealthy industrialist, who became psychologically addicted to the brew, alerted the unsuspecting to the dangers of radium salt elixirs. Most abuses finally ended after the legislation in the 1950s.

The image shows an old advertisement of radium material branded as UNDARK with the tagline “Shines in the Dark.”
The properties of radiation were once touted for far more than its modern use in cancer therapy. Until 1932, radium was advertised for a variety of uses, often with tragic results. (credit: Struthious Bandersnatch.)

Radiotherapy is effective against cancer because cancer cells reproduce rapidly and, consequently, are more sensitive to radiation. The central problem in radiotherapy is to make the dose for cancer cells as high as possible while limiting the dose for normal cells. The ratio of abnormal cells killed to normal cells killed is called the therapeutic ratio    , and all radiotherapy techniques are designed to enhance this ratio. Radiation can be concentrated in cancerous tissue by a number of techniques. One of the most prevalent techniques for well-defined tumors is a geometric technique shown in [link] . A narrow beam of radiation is passed through the patient from a variety of directions with a common crossing point in the tumor. This concentrates the dose in the tumor while spreading it out over a large volume of normal tissue. The external radiation can be x-rays, 60 Co  γ rays, or ionizing-particle beams produced by accelerators. Accelerator-produced beams of neutrons, π-mesons , and heavy ions such as nitrogen nuclei have been employed, and these can be quite effective. These particles have larger QFs or RBEs and sometimes can be better localized, producing a greater therapeutic ratio. But accelerator radiotherapy is much more expensive and less frequently employed than other forms.

The image shows a man lying on a flat surface. A gamma ray machine is rotated around the man.
The 60 Co source of γ -radiation is rotated around the patient so that the common crossing point is in the tumor, concentrating the dose there. This geometric technique works for well-defined tumors.

Questions & Answers

how lesers can transmit information
mitul Reply
griffts bridge derivative
Ganesh Reply
below me
please explain; when a glass rod is rubbed with silk, it becomes positive and the silk becomes negative- yet both attracts dust. does dust have third types of charge that is attracted to both positive and negative
Timothy Reply
what is a conductor
Timothy
hello
Timothy
below me
why below you
Timothy
no....I said below me ...... nothing below .....ok?
dust particles contains both positive and negative charge particles
Mbutene
corona charge can verify
Stephen
when pressure increases the temperature remain what?
Ibrahim Reply
what is frequency
Mbionyi Reply
define precision briefly
Sujitha Reply
CT scanners do not detect details smaller than about 0.5 mm. Is this limitation due to the wavelength of x rays? Explain.
MITHRA Reply
hope this helps
what's critical angle
Mahmud Reply
The Critical Angle Derivation So the critical angle is defined as the angle of incidence that provides an angle of refraction of 90-degrees. Make particular note that the critical angle is an angle of incidence value. For the water-air boundary, the critical angle is 48.6-degrees.
dude.....next time Google it
okay whatever
Chidalu
pls who can give the definition of relative density?
Temiloluwa
the ratio of the density of a substance to the density of a standard, usually water for a liquid or solid, and air for a gas.
Chidalu
What is momentum
aliyu Reply
mass ×velocity
Chidalu
it is the product of mass ×velocity of an object
Chidalu
how do I highlight a sentence]p? I select the sentence but get options like copy or web search but no highlight. tks. src
Sean Reply
then you can edit your work anyway you want
Wat is the relationship between Instataneous velocity
Oyinlusi Reply
Instantaneous velocity is defined as the rate of change of position for a time interval which is almost equal to zero
Astronomy
The potential in a region between x= 0 and x = 6.00 m lis V= a+ bx, where a = 10.0 V and b = -7.00 V/m. Determine (a) the potential atx=0, 3.00 m, and 6.00 m and (b) the magnitude and direction of the electric ficld at x =0, 3.00 m, and 6.00 m.
what is energy
Victor Reply
hi all?
GIDEON
hey
Bitrus
energy is when you finally get up of your lazy azz and do some real work 😁
what is physics
faith Reply
what are the basic of physics
faith
base itself is physics
Vishlawath
tree physical properties of heat
Bello Reply
tree is a type of organism that grows very tall and have a wood trunk and branches with leaves... how is that related to heat? what did you smoke man?
algum profe sabe .. Progressivo ou Retrógrado e Acelerado ou Retardado   V= +23 m/s        V= +5 m/s        0__>              0__> __________________________>        T= 0               T=6s
Claudia
Practice Key Terms 2

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Source:  OpenStax, College physics. OpenStax CNX. Jul 27, 2015 Download for free at http://legacy.cnx.org/content/col11406/1.9
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