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The replication mechanism depends on the viral genome. DNA viruses usually use host cell proteins and enzymes to make additional DNA that is used to copy the genome or be transcribed to messenger RNA (mRNA), which is then used in protein synthesis. RNA viruses, such as the influenza virus, usually use the RNA core as a template for synthesis of viral genomic RNA and mRNA. The viral mRNA is translated into viral enzymes and capsid proteins to assemble new virions ( [link] ). Of course, there are exceptions to this pattern. If a host cell does not provide the enzymes necessary for viral replication, viral genes supply the information to direct synthesis of the missing proteins. Retroviruses, such as HIV, have an RNA genome that must be reverse transcribed to make DNA, which then is inserted into the host’s DNA. To convert RNA into DNA, retroviruses contain genes that encode the virus-specific enzyme reverse transcriptase that transcribes an RNA template to DNA. The fact that HIV produces some of its own enzymes, which are not found in the host, has allowed researchers to develop drugs that inhibit these enzymes. These drugs, including the reverse transcriptase inhibitor AZT, inhibit HIV replication by reducing the activity of the enzyme without affecting the host’s metabolism.

The last stage of viral replication is the release of the new virions into the host organism, where they are able to infect adjacent cells and repeat the replication cycle. Some viruses are released when the host cell dies and other viruses can leave infected cells by budding through the membrane without directly killing the cell.

Art connection

The illustration shows the steps of an influenza virus infection. In step 1, influenza virus becomes attached to a receptor on a target epithelial cell. In step 2, the cell engulfs the virus by endocytosis, and the virus becomes encased in the cell’s plasma membrane. In step 3, the membrane dissolves, and the viral contents are released into the cytoplasm. Viral mRNA enters the nucleus, where it is replicated by viral RNA polymerase. In step 4, viral mRNA exits to the cytoplasm, where it is used to make viral proteins. In step 5, new viral particles are released into the extracellular fluid. The cell, which is not killed in the process, continues to make new virus.
In influenza virus infection, glycoproteins attach to a host epithelial cell. As a result, the virus is engulfed. RNA and proteins are made and assembled into new virions.

Influenza virus is packaged in a viral envelope, which fuses with the plasma membrane. This way, the virus can exit the host cell without killing it. What advantage does the virus gain by keeping the host cell alive?

Concept in action

Click through this tutorial on viruses to identify structures, modes of transmission, replication, and more.

Viruses and disease

Viruses cause a variety of diseases in animals, including humans, ranging from the common cold to potentially fatal illnesses like meningitis ( [link] ). These diseases can be treated by antiviral drugs or by vaccines, but some viruses, such as HIV, are capable of avoiding the immune response and mutating so as to become resistant to antiviral drugs.

The illustration shows an overview of human viral diseases. Viruses that cause encephalitis or meningitis, or inflammation of the brain and surrounding tissues, include measles, arbovirus, rabies, JC virus, and LCM virus. The common cold is caused by rhinovirus, parainfluenza virus, and respiratory syncytial virus. Eye infections are caused by herpesvirus, adenovirus, and cytomegalovirus. Pharyngitis, or inflammation of the pharynx, is caused by adenovirus, Epstein-Barr virus, and cytomegalovirus. Parotitis, or inflammation of the parotid glands, is caused by mumps virus. Gingivostomatitis, or inflammation of the oral mucosa, is caused by herpes simplex type I virus. Pneumonia is caused by influenza virus types A and B, parainfluenza virus, respiratory syncytial virus, adenovirus, and SARS coronavirus. Cardiovascular problems are caused by coxsackie B virus. Hepatitis is caused by hepatitis virus types A, B, C, D, and E. Myelitis is caused by poliovirus and HLTV-1. Skin infections are caused by varicella-zoster virus, human herpesvirus 6, smallpox, molluscum contagiosum, human papillomavirus, parvovirus B19, rubella, measles, and coxsackie A virus. Gastroenteritis, or digestive disease, is caused by adenovirus, rotavirus, norovirus, astrovirus, and coronavirus. Sexually transmitted diseases are caused by herpes simplex type 2, human papillomavirus, and HIV. Pancreatitis B is caused by coxsackie B virus.
Viruses are the cause of dozens of ailments in humans, ranging from mild illnesses to serious diseases. (credit: modification of work by Mikael Häggström)

Vaccines for prevention

While we do have limited numbers of effective antiviral drugs, such as those used to treat HIV and influenza, the primary method of controlling viral disease is by vaccination, which is intended to prevent outbreaks by building immunity to a virus or virus family. A vaccine    may be prepared using weakened live viruses, killed viruses, or molecular subunits of the virus. In general, live viruses lead to better immunity, but have the possibility of causing disease at some low frequency. Killed viral vaccine and the subunit viruses are both incapable of causing disease, but in general lead to less effective or long-lasting immunity.

Questions & Answers

what is monopoli power
Adzaho Reply
the situation that prevails when economic forces balance so that economic variables neither increase nor decrease
Bombey
what is equilibrium
Kabir
what are the important of economic to accounting students with references
salihu Reply
Economics is important because it helps people understand how a variety of factors work with and against each other to control how resources such as labor and capital get used, and how inflation, supply, demand, interest rates and other factors determine how much you pay for goods and services.
Muhammad
explain the steps taken by the government in developing rural market?
Azeem Reply
contribution of Adam smith in economics
abel Reply
I will join
Dexter
I will join
Patrick
Hey
Fatima
Hey
Amir
Hello
AS
hey
Umarou
I love this book and i need extra Economic book
Amir
Hey
Amir
what's happening here
AS
I love this book and i need extra Economic book
Amir
what is the meaning of function in economics
Effah Reply
Pls, I need more explanation on price Elasticity of Supply
Isaac Reply
Is the degree to the degree of responsiveness of a change in quantity supplied of goods to a change in price
Afran
what is production
Humaira
Okay what is land mobile and land unmobile
scor
And what are the resources in land
scor
what is production
Humaira
the proces of using the services of labor and equipmnt together with other in puts to make goods and services availble
Bombey
Okay what is land mobile and land unmobile
scor
Discuss the short-term and long-term balance positions of the firm in the monopoly market?
Rabindranath Reply
hey
Soumya
hi
Mitiku
how are you?
Mitiku
can you tell how can i economics honurs(BSC) in reputed college?
Soumya
through hard study and performing well than expected from you
Mitiku
what should i prepare for it?
Soumya
prepare first, in psychologically as well as potentially to sacrifice what's expected from you, when I say this I mean that you have to be ready, for every thing and to accept failure as a good and you need to change them to potential for achievement of ur goals
Mitiku
parna kya hai behencho?
Soumya
Hallo
Rabindranath
Hello, dear what's up?
Mitiku
cool
Momoh
good morning
Isaac
pls, is anyone here from Ghana?
Isaac
Hw s every one please
Afran
Ys please I'm in Ghana
Afran
Hello
OLANIYI
pls anyone from Nigeria
OLANIYI
am a new candidate here, can someone put me 2ru
OLANIYI
hello
OLANIYI
Pls economic A level exam tomorrow pls help me
akinwale
am from Ghana
Jacob
hi
Charles
Pls economic A level exam tomorrow pls help me
akinwale
Hi
Dev
bol Diya discuss ab krega v
Dev
hello Mr. Rabindranath
Dev
what do you want Dimlare
Dev
yes tell me your desire to have it
Dev
to have what?
OLANIYI
Good luck
JOSEPH
I want to know about economic A level tomorrow pls help
Lerato
okay
Umarou
okay
Umarou
hi
Humaira
hi
Liaqat
what is firms
Anteyi Reply
A firm is a business entity which engages in the production of goods and aimed at making profit.
Avuwada
What is autarky in Economics.
Avuwada
what is choice
Tia Reply
So how is the perfect competition different from others
Rev Reply
what is choice
Tia
please what type of commodity is 1.Beaf 2.Suagr 3.Bread
Alfred Reply
1
Naziru
what is the difference between short run and long run?
Ukpen Reply
It just depends on how far you would like to run!!!🤣🤣🤣
Anna
meaning? You guys need not to be playing here; if you don't know a question, leave it for he that knows.
Ukpen
pls is question from which subject or which course
Ada
Is this not economics?
Ukpen
This place is meant to be for serious educational matters n not playing ground so pls let's make it a serious place.
Docky
Is there an economics expert here?
Docky
Okay and I was being serous
Anna
The short run is a period of time in which the quantity of at least one inputs is fixed...
Anna
that is the answer that I found online and in my text book
Anna
Elacisity
salihu
Meaning of economics
Suraj Reply
It will creates rooms for an effective demands.
Chinedum Reply
different between production and supply
babsnof
Hii
Suraj
hlo
eshita
What is the economic?
Suraj
Economics is a science which study human behavior as a relationship between ends and scarce means which has an alternative use.
Mr
what is supply
babsnof
what is different between demand and supply
Debless Reply
Demand refers to the quantity of products that consumers are willing to purchase at various prices per time while Supply has to do with the quantity of products suppliers are willing to supply at various prices per time. find the difference in between
Saye
what is demand
Humaira
demand is a relationship btn the price of an item and the quantity demanded
Bombey
Difference between extinct and extici spicies
Amanpreet Reply
Which of the following is best at showing the life expandency of an individual within a a population
Daniel Reply
perianth is present in which gymnosperms ?
DebaXish Reply
perianth is present in which gymnos4perms ?
DebaXish Reply

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Source:  OpenStax, Bi 101 for lbcc ilearn campus. OpenStax CNX. Nov 28, 2013 Download for free at http://legacy.cnx.org/content/col11593/1.1
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