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During elongation, an enzyme called DNA polymerase adds DNA nucleotides to the 3' end of the template. Because DNA polymerase can only add new nucleotides at the end of a backbone, a primer sequence, which provides this starting point, is added with complementary RNA nucleotides. This primer is removed later, and the nucleotides are replaced with DNA nucleotides. One strand, which is complementary to the parental DNA strand, is synthesized continuously toward the replication fork so the polymerase can add nucleotides in this direction. This continuously synthesized strand is known as the leading strand . Because DNA polymerase can only synthesize DNA in a 5' to 3' direction, the other new strand is put together in short pieces called Okazaki fragments . The Okazaki fragments each require a primer made of RNA to start the synthesis. The strand with the Okazaki fragments is known as the lagging strand . As synthesis proceeds, an enzyme removes the RNA primer, which is then replaced with DNA nucleotides, and the gaps between fragments are sealed by an enzyme called DNA ligase .

The process of DNA replication can be summarized as follows:

  1. DNA unwinds at the origin of replication.
  2. New bases are added to the complementary parental strands. One new strand is made continuously, while the other strand is made in pieces.
  3. Primers are removed, new DNA nucleotides are put in place of the primers and the backbone is sealed by DNA ligase.
Illustration shows a replication bubble. Helicase unwinds the helix. An RNA primer starts the synthesis, and DNA polymerase extends the DNA strand from the RNA primer. DNA synthesis occurs only in the 5' to 3' direction. On the leading strand, DNA synthesis occurs continuously. On the lagging strand, DNA synthesis restarts many times as the helix unwinds, resulting in many short fragments called Okazaki fragments.
A replication fork is formed by the opening of the origin of replication, and helicase separates the DNA strands. An RNA primer is synthesized, and is elongated by the DNA polymerase. On the leading strand, DNA is synthesized continuously, whereas on the lagging strand, DNA is synthesized in short stretches. The DNA fragments are joined by DNA ligase (not shown).

Telomere replication

Because eukaryotic chromosomes are linear, DNA replication comes to the end of a line in eukaryotic chromosomes. As you have learned, the DNA polymerase enzyme can add nucleotides in only one direction. In the leading strand, synthesis continues until the end of the chromosome is reached; however, on the lagging strand there is no place for a primer to be made for the DNA fragment to be copied at the end of the chromosome. This presents a problem for the cell because the ends remain unpaired, and over time these ends get progressively shorter as cells continue to divide. The ends of the linear chromosomes are known as telomeres , which have repetitive sequences that do not code for a particular gene. As a consequence, it is telomeres that are shortened with each round of DNA replication instead of genes. For example, in humans, a six base-pair sequence, TTAGGG, is repeated 100 to 1000 times. The discovery of the enzyme telomerase ( [link] ) helped in the understanding of how chromosome ends are maintained. The telomerase attaches to the end of the chromosome, and complementary bases to the RNA template are added on the end of the DNA strand. Once the lagging strand template is sufficiently elongated, DNA polymerase can now add nucleotides that are complementary to the ends of the chromosomes. Thus, the ends of the chromosomes are replicated.

Questions & Answers

what's a psy.d degree
Robin Reply
Psychology Doctorate. The main difference between PsyD and PhD Psychology is that PsyD mainly focuses on clinical sessions and PhD focuses on research.
Shrajan
so most of the phd holders become professors teaching what they have learnt
Bridget
Hi, I have a question. What factors influence social facilitation and social inhibition in groups?
Amritpal Reply
it really depends on that person on how the can task in life either they can work better with other people or you do worse working with people.
Lametra
the task
Lametra
they task
Lametra
Do you know of any studies done to show social facilitation and social inhibition
Amritpal
social facilitation is often influenced by the person's perception of the situation and their appraisal of the task. for example, a track athlete who views their competition as a challenge rather than a threat, will tend to run the fastest they have ever ran under a large crowd.
fady
Another condition is if the person has mastered the ability to perform that task. A track athlete who trains everyday, will perform above average under a large crowd, however, someone who does not run, will tend to do worse than their actual ability under a large crowd
fady
social inhibition can be explained through evolutionary biology or attachment personality theory. some people develop an avoidance personality trait, which when they feel under pressure, they tend to leave the group or avoid a gathering due to high lev of stress
fady
Does anyone know how I can transfer my higher national diploma credits in usa?
Qwanta Reply
Oh wow. I never realised there was a chat on this app!
Amritpal Reply
Then welcome dearest
Bridget
Thank you! ❤️
Amritpal
thank you
Ana
Hello Ana, good afternoon from here
Philip Reply
hello im new student here.
Junalyn Reply
o sorry madm
Rai
hello
Rai
I m also student.
Rai
hi
Kavya
what is easier option to psychology?
Dhanaraj
I'm new too
Deniz
As in the the specialisation or ?
Bridget
good morning
Ana
understanding human nature is what we are going to talk about.
Ana
okay, go ahead
Philip
“ Every child is left to evaluate his experiences for himself, and to take care of his own personal development outside the classroom. There is no tradition for the acquisition of a true knowledge of the human psyche. The science of human nature thus finds itself today in the position that chemis
Ana
well, I think every individual is different and to a great extent we can't say confidently that we understand the human nature in its entirety
Philip
lack determines what we will become in life?.
Ana
Not 100% but it plays a huge role
Philip
Hi! I wasn't aware there was a chat feature on this app 😊
Ophelia
👍Philip Anyaegbu
Ana
cool
Ana
👍
Ana
yes Ana I'm here
Philip
alternatively we are different, we have basic similar qualities
Bridget
Yes true Bridget.
Philip
hello there
Ciel
Hi
Philip
hi
Ej
hi
KUNDAN
hi
Ana
who we are how we think what we do insight
Ana
@ bridget. yes that's true
Ana
Ana ioanidis? do you speak Greek?
Qwanta
Qwanta no I dont speak Greek my husband does
Ana
are you a psychologist? or your husband?
Qwanta
I need some reliable informations about my studies...
Qwanta
not a psychologist
Ana
I ask questions
Ana
so what is the cause why a person experiences a psychological disorder if it not of their own?
Junalyn Reply
it's partly genetics,culture, environment and substance abuse. generally these are the common factors which can lead to most of the disorders
war
waoo
Rai
r u proficcer
Rai
u r psychology subject
Rai
not a professor but a clinical psychologist
war
can i ask you, i keep getting headache, and had a history of hypothyroid ans diagnosed as having mild anxiety disorder. i want to finish. my undergraduate psychology thesis.. but always unable to have good ambition and energy to focus on writing the case and the theories... whats the best remedy
Astaroxche
had a headache and have a history
Ana
297 according to the DSM 5
fady
how many disorders are there
Janareon Reply
interesting question
Mahmoud
it is😅
Nelly
I'm guessing it's in the tens of thousands, maybe hundreds if you include counter interactions and stuff like it. although I'm sure it's almost impossible to know for sure, unless you're very rich and connected to the right people. but as I said: guessing.
Beenie
There are more than 200 classified forms of mental illness. Some of the more common disorders are: clinical depression, bipolar disorder, dementia, schizophrenia and anxiety disorders. Symptoms may include changes in mood, personality, personal habits and/or social withdrawal. that is what I think
Mahmoud
too difficult to number. diagnosing a disorder is just checking off boxes on a compilation of symptoms that might match any particular condition on the DSM
what is psychology of the guest
Lirilong Reply
I don't understand the question can you elaborate?
Edgar
the study of philosophy gives to the sociologist
Aman Reply
why women are viewed as far more emotional than men?
Wario Reply
because they actually are ,I guess.
Collins
May be they are biologically milder than man. It does not mean they are not equal with man. Man can also be emotional and can are oppressed with traditional norms. For example, man are not to be cry, in actual man are also emotional being and they cannot have the right to show their sentiment.
shine
sollungal bro sollungal...
Balaji
because of she has hormonal fluctuations than men..
bavi
usually women are more emotional than men and they are multi talented people
lavanya
Both men and women are capable of expressing emotions. But women has the highest percentage of doing that. Because our society is conditioned by nature in such a way that men are expected to suppress their emotions and motivate them through their acts or thoughts, which has it's side effects of....
Santos
denial of any emotion which they feel that useless at that point. Women in the other hand were encouraged/not controlled to suppress their emotions and let them out what they feel about it. I feel that's the wonderful superpower of the women.
Santos
y
Mahmoud
Men's emotion comes mostly with memories triggered by senses. That means, they thoughts have the power to decide whether to let go of emotions or not.
Santos
Q
Mark
because women tend to be more agreeable than men.
Edgar
women at a young age are conditioned to be more in tune with emotion than man should be less
David
The question is "Why women Viewed are as far more emotional than men ?" it's not a question whether women are more emotional than men. This is more an issue about the point of view from the observer, his/her assumption what emotional behavior is or what emotional behavior is.
Mehmet
The anwers are answers more to the question " Are women more emotional than men?"
Mehmet
hi are you on what'sap
Wunuji Reply
no not really a fan of social laziness
Robert
huh
Parmizan
is there any way for a Btech E.C.E. graduate to take on MSC. PSYCHOLOGY
devesh
ya you can just by cracking entrance , if in India
Mansi
Any stream in UG can go for M.Sc (Psychology)
classification of traits and how they are measured
chinedu Reply
what was Freud's first name?
Robin Reply
Sigmund
Dentriodite
sigmund
Margie
Sigismund Schlomo Freud
Mohammad
Sigmund Freud
Talal
sigmund
Ankita
Leon Vygotsky and Sergei Rubenstein please tell me contributions of these personalities in in 4 lines
Uzma
sigmund Freud
Harpreet
Lev Vygotsky was the founder of socio-cultural theory
Jo
So psychology was based off of the Greek gods I that right or no?
Tanya Reply
psychology is the study. anything -ology is the study of a certain field. Psyche is a mortal woman who becomes divine in Greek mythology. The etymology of the word "psyche" in Greek means "spirit" or "soul"
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Source:  OpenStax, Principles of biology. OpenStax CNX. Aug 09, 2016 Download for free at http://legacy.cnx.org/content/col11569/1.25
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