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By the end of this chapter, you will be able to:
  • Describe the roles of male and female reproductive hormones
  • Discuss the interplay of the ovarian and menstrual cycles
  • Describe the process of menopause

The human male and female reproductive cycles are controlled by the interaction of hormones from the hypothalamus and anterior pituitary with hormones from reproductive tissues and organs. In both sexes, the hypothalamus monitors and causes the release of hormones from the pituitary gland. When the reproductive hormone is required, the hypothalamus sends a gonadotropin-releasing hormone (GnRH)    to the anterior pituitary. This causes the release of follicle stimulating hormone (FSH)    and luteinizing hormone (LH)    from the anterior pituitary into the blood. Note that the body must reach puberty in order for the adrenals to release the hormones that must be present for GnRH to be produced. Although FSH and LH are named after their functions in female reproduction, they are produced in both sexes and play important roles in controlling reproduction. Other hormones have specific functions in the male and female reproductive systems.

Male hormones

At the onset of puberty, the hypothalamus causes the release of FSH and LH into the male system for the first time. FSH enters the testes and stimulates the Sertoli cells to begin facilitating spermatogenesis using negative feedback, as illustrated in [link] . LH also enters the testes and stimulates the interstitial cells of Leydig to make and release testosterone into the testes and the blood.

Testosterone , the hormone responsible for the secondary sexual characteristics that develop in the male during adolescence, stimulates spermatogenesis. These secondary sex characteristics include a deepening of the voice, the growth of facial, axillary, and pubic hair, and the beginnings of the sex drive.

Hormonal control of the male reproductive system is mediated by the hypothalamus, anterior pituitary and testes. The hypothalamus releases GnRN, causing the anterior pituitary to release LH and FSH. FSH and LH both act on the testes. FSH stimulates the Sertoli cells in the testes to facilitate spermatogenesis and to secrete inhibin. LH causes the Leydig cells in the testes to secrete testosterone. Testosterone further stimulates spermatogenesis by the Sertoli cells, but inhibits GnRH, LH, and FSH production by the hypothalamus and anterior pituitary. Inhibin secreted by Sertoli cells also inhibits FSH and LH production by the anterior pituitary.
Hormones control sperm production in a negative feedback system.

A negative feedback system occurs in the male with rising levels of testosterone acting on the hypothalamus and anterior pituitary to inhibit the release of GnRH, FSH, and LH. The Sertoli cells produce the hormone inhibin    , which is released into the blood when the sperm count is too high. This inhibits the release of GnRH and FSH, which will cause spermatogenesis to slow down. If the sperm count reaches 20 million/ml, the Sertoli cells cease the release of inhibin, and the sperm count increases.

Female hormones

The control of reproduction in females is more complex. As with the male, the anterior pituitary hormones cause the release of the hormones FSH and LH. In addition, estrogens and progesterone are released from the developing follicles. Estrogen is the reproductive hormone in females that assists in endometrial regrowth, ovulation, and calcium absorption; it is also responsible for the secondary sexual characteristics of females. These include breast development, flaring of the hips, and a shorter period necessary for bone maturation. Progesterone assists in endometrial re-growth and inhibition of FSH and LH release.

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Source:  OpenStax, University of georgia concepts of biology. OpenStax CNX. May 28, 2013 Download for free at https://legacy.cnx.org/content/col11526/1.2
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