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The example of the WISDOM project illustrates one way in which biomedicine has benefited from computer-enabled methods of research, through use of grid technology. Taking advantage of large number of computing resources available in such distributed computing infrastructure, it was permitted to address simulations of drug-discovery and also to proceed to disease monitoring by the dynamical aspect of grid. Epidemiology and computer-intensive analysis of geographically distributed medical images are other inpiring researches of the grid paradigm.

Key concepts

  • biomedical research
  • drug discovery
  • docking
  • telemedicine
  • radiotherapy
  • epidemiology

Introduction

Biosciences research provides an exemplar of the dramatic transformation occurring within the context of data rich science. Increased emphasis on biology as an “informational science” focused on genomics has resulted in the production of huge data sets that can only be adequately managed and decoded by using advanced information technologies (ICTs). Researchers studying biology at higher levels of organisation than the genome also rely on ICTs to develop models of cells, tissues, organisms and ecologies, in order to come to terms with complexity. Biomedical science aided by ICTs has made significant advances in areas such as the understanding of disease processes (for instance in heart or cancer modelling) and drug discovery.

Biomedicine consists of various aspects which can benefit from a grid-based approach including the search for new drug targets into the genome and the proteome, identification of single nucleotide polymorphisms (SNPs) relating to drug sensitivity, drug resistance mechanism elucidations as well as epidemiological monitoring of disease outbreaks. Well-identified areas of relevance of the grid paradigm are epidemiology and computer-intensive analysis of geographically distributed medical images. Grids are defined as fully distributed, dynamically reconfigurable, scalable and autonomous infrastructures to provide location independent, pervasive, reliable, secure and efficient access to a coordinated set of services encapsulating and virtualising resource. Their relevance for biomedical research has been investigated within the framework of the HealthGrid initiative (Breton et al. 2005, SHARE Project 2008). Here we focus on the use of e-Research methods in the study of infectious diseases such as flu viruses and malaria and Medical Data Management.

Grid as a surveillance tool for diseases

Epidemiology focused on population-level research requires access to distributed, critically sensitive and heterogeneous data, resulting in overall costly computing processes. The study of flu viruses and their treatment is one notable example of e-Research in biomedical sciences. Recent years have seen the emergence of diseases which have spread very quickly around the world, either through human travel, like SARS and SIV (H1N1), or animal migration, like avian flu (H5N1). Swine Flu has been in the headlines in 2009, officially classified as a “pandemic” by the World Health Organization in response to the virus’s worldwide geographic spread (Neumann, Noda and Kawaoka 2009). International collaboration has involved use of grid computing to model potential circumstances surrounding such extreme outbreaks.

Questions & Answers

where we get a research paper on Nano chemistry....?
Maira Reply
what are the products of Nano chemistry?
Maira Reply
There are lots of products of nano chemistry... Like nano coatings.....carbon fiber.. And lots of others..
learn
Even nanotechnology is pretty much all about chemistry... Its the chemistry on quantum or atomic level
learn
Google
da
no nanotechnology is also a part of physics and maths it requires angle formulas and some pressure regarding concepts
Bhagvanji
Preparation and Applications of Nanomaterial for Drug Delivery
Hafiz Reply
revolt
da
Application of nanotechnology in medicine
what is variations in raman spectra for nanomaterials
Jyoti Reply
I only see partial conversation and what's the question here!
Crow Reply
what about nanotechnology for water purification
RAW Reply
please someone correct me if I'm wrong but I think one can use nanoparticles, specially silver nanoparticles for water treatment.
Damian
yes that's correct
Professor
I think
Professor
Nasa has use it in the 60's, copper as water purification in the moon travel.
Alexandre
nanocopper obvius
Alexandre
what is the stm
Brian Reply
is there industrial application of fullrenes. What is the method to prepare fullrene on large scale.?
Rafiq
industrial application...? mmm I think on the medical side as drug carrier, but you should go deeper on your research, I may be wrong
Damian
How we are making nano material?
LITNING Reply
what is a peer
LITNING Reply
What is meant by 'nano scale'?
LITNING Reply
What is STMs full form?
LITNING
scanning tunneling microscope
Sahil
how nano science is used for hydrophobicity
Santosh
Do u think that Graphene and Fullrene fiber can be used to make Air Plane body structure the lightest and strongest. Rafiq
Rafiq
what is differents between GO and RGO?
Mahi
what is simplest way to understand the applications of nano robots used to detect the cancer affected cell of human body.? How this robot is carried to required site of body cell.? what will be the carrier material and how can be detected that correct delivery of drug is done Rafiq
Rafiq
if virus is killing to make ARTIFICIAL DNA OF GRAPHENE FOR KILLED THE VIRUS .THIS IS OUR ASSUMPTION
Anam
analytical skills graphene is prepared to kill any type viruses .
Anam
Any one who tell me about Preparation and application of Nanomaterial for drug Delivery
Hafiz
what is Nano technology ?
Bob Reply
write examples of Nano molecule?
Bob
The nanotechnology is as new science, to scale nanometric
brayan
nanotechnology is the study, desing, synthesis, manipulation and application of materials and functional systems through control of matter at nanoscale
Damian
Is there any normative that regulates the use of silver nanoparticles?
Damian Reply
what king of growth are you checking .?
Renato
What fields keep nano created devices from performing or assimulating ? Magnetic fields ? Are do they assimilate ?
Stoney Reply
why we need to study biomolecules, molecular biology in nanotechnology?
Adin Reply
?
Kyle
yes I'm doing my masters in nanotechnology, we are being studying all these domains as well..
Adin
why?
Adin
what school?
Kyle
biomolecules are e building blocks of every organics and inorganic materials.
Joe
how did you get the value of 2000N.What calculations are needed to arrive at it
Smarajit Reply
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Source:  OpenStax, Research in a connected world. OpenStax CNX. Nov 22, 2009 Download for free at http://cnx.org/content/col10677/1.12
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