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The example of the WISDOM project illustrates one way in which biomedicine has benefited from computer-enabled methods of research, through use of grid technology. Taking advantage of large number of computing resources available in such distributed computing infrastructure, it was permitted to address simulations of drug-discovery and also to proceed to disease monitoring by the dynamical aspect of grid. Epidemiology and computer-intensive analysis of geographically distributed medical images are other inpiring researches of the grid paradigm.

Key concepts

  • biomedical research
  • drug discovery
  • docking
  • telemedicine
  • radiotherapy
  • epidemiology

Introduction

Biosciences research provides an exemplar of the dramatic transformation occurring within the context of data rich science. Increased emphasis on biology as an “informational science” focused on genomics has resulted in the production of huge data sets that can only be adequately managed and decoded by using advanced information technologies (ICTs). Researchers studying biology at higher levels of organisation than the genome also rely on ICTs to develop models of cells, tissues, organisms and ecologies, in order to come to terms with complexity. Biomedical science aided by ICTs has made significant advances in areas such as the understanding of disease processes (for instance in heart or cancer modelling) and drug discovery.

Biomedicine consists of various aspects which can benefit from a grid-based approach including the search for new drug targets into the genome and the proteome, identification of single nucleotide polymorphisms (SNPs) relating to drug sensitivity, drug resistance mechanism elucidations as well as epidemiological monitoring of disease outbreaks. Well-identified areas of relevance of the grid paradigm are epidemiology and computer-intensive analysis of geographically distributed medical images. Grids are defined as fully distributed, dynamically reconfigurable, scalable and autonomous infrastructures to provide location independent, pervasive, reliable, secure and efficient access to a coordinated set of services encapsulating and virtualising resource. Their relevance for biomedical research has been investigated within the framework of the HealthGrid initiative (Breton et al. 2005, SHARE Project 2008). Here we focus on the use of e-Research methods in the study of infectious diseases such as flu viruses and malaria and Medical Data Management.

Grid as a surveillance tool for diseases

Epidemiology focused on population-level research requires access to distributed, critically sensitive and heterogeneous data, resulting in overall costly computing processes. The study of flu viruses and their treatment is one notable example of e-Research in biomedical sciences. Recent years have seen the emergence of diseases which have spread very quickly around the world, either through human travel, like SARS and SIV (H1N1), or animal migration, like avian flu (H5N1). Swine Flu has been in the headlines in 2009, officially classified as a “pandemic” by the World Health Organization in response to the virus’s worldwide geographic spread (Neumann, Noda and Kawaoka 2009). International collaboration has involved use of grid computing to model potential circumstances surrounding such extreme outbreaks.

Questions & Answers

what is math number
Tric Reply
x-2y+3z=-3 2x-y+z=7 -x+3y-z=6
Sidiki Reply
Need help solving this problem (2/7)^-2
Simone Reply
x+2y-z=7
Sidiki
what is the coefficient of -4×
Mehri Reply
-1
Shedrak
the operation * is x * y =x + y/ 1+(x × y) show if the operation is commutative if x × y is not equal to -1
Alfred Reply
An investment account was opened with an initial deposit of $9,600 and earns 7.4% interest, compounded continuously. How much will the account be worth after 15 years?
Kala Reply
lim x to infinity e^1-e^-1/log(1+x)
given eccentricity and a point find the equiation
Moses Reply
12, 17, 22.... 25th term
Alexandra Reply
12, 17, 22.... 25th term
Akash
College algebra is really hard?
Shirleen Reply
Absolutely, for me. My problems with math started in First grade...involving a nun Sister Anastasia, bad vision, talking & getting expelled from Catholic school. When it comes to math I just can't focus and all I can hear is our family silverware banging and clanging on the pink Formica table.
Carole
I'm 13 and I understand it great
AJ
I am 1 year old but I can do it! 1+1=2 proof very hard for me though.
Atone
hi
Adu
Not really they are just easy concepts which can be understood if you have great basics. I am 14 I understood them easily.
Vedant
hi vedant can u help me with some assignments
Solomon
find the 15th term of the geometric sequince whose first is 18 and last term of 387
Jerwin Reply
I know this work
salma
The given of f(x=x-2. then what is the value of this f(3) 5f(x+1)
virgelyn Reply
hmm well what is the answer
Abhi
If f(x) = x-2 then, f(3) when 5f(x+1) 5((3-2)+1) 5(1+1) 5(2) 10
Augustine
how do they get the third part x = (32)5/4
kinnecy Reply
make 5/4 into a mixed number, make that a decimal, and then multiply 32 by the decimal 5/4 turns out to be
AJ
how
Sheref
can someone help me with some logarithmic and exponential equations.
Jeffrey Reply
sure. what is your question?
ninjadapaul
20/(×-6^2)
Salomon
okay, so you have 6 raised to the power of 2. what is that part of your answer
ninjadapaul
I don't understand what the A with approx sign and the boxed x mean
ninjadapaul
it think it's written 20/(X-6)^2 so it's 20 divided by X-6 squared
Salomon
I'm not sure why it wrote it the other way
Salomon
I got X =-6
Salomon
ok. so take the square root of both sides, now you have plus or minus the square root of 20= x-6
ninjadapaul
oops. ignore that.
ninjadapaul
so you not have an equal sign anywhere in the original equation?
ninjadapaul
hmm
Abhi
is it a question of log
Abhi
🤔.
Abhi
I rally confuse this number And equations too I need exactly help
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But this is not salma it's Faiza live in lousvile Ky I garbage this so I am going collage with JCTC that the of the collage thank you my friends
salma
Commplementary angles
Idrissa Reply
hello
Sherica
im all ears I need to learn
Sherica
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Tamia
hii
Uday
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salma
hi
Ayuba
Hello
opoku
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Ali
greetings from Iran
Ali
salut. from Algeria
Bach
hi
Nharnhar
A soccer field is a rectangle 130 meters wide and 110 meters long. The coach asks players to run from one corner to the other corner diagonally across. What is that distance, to the nearest tenths place.
Kimberly Reply
Jeannette has $5 and $10 bills in her wallet. The number of fives is three more than six times the number of tens. Let t represent the number of tens. Write an expression for the number of fives.
August Reply
What is the expressiin for seven less than four times the number of nickels
Leonardo Reply
How do i figure this problem out.
how do you translate this in Algebraic Expressions
linda Reply
why surface tension is zero at critical temperature
Shanjida
I think if critical temperature denote high temperature then a liquid stats boils that time the water stats to evaporate so some moles of h2o to up and due to high temp the bonding break they have low density so it can be a reason
s.
Need to simplify the expresin. 3/7 (x+y)-1/7 (x-1)=
Crystal Reply
. After 3 months on a diet, Lisa had lost 12% of her original weight. She lost 21 pounds. What was Lisa's original weight?
Chris Reply
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Source:  OpenStax, Research in a connected world. OpenStax CNX. Nov 22, 2009 Download for free at http://cnx.org/content/col10677/1.12
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