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This module is an introduction to performing searches of the NCBI databases using Entrez, the NCBI web-based search and retrieval tool for integrated search results from multiple databases.

Entrez (1) is a search and retrieval tool developed by NCBI that is capable of searching multiple NCBI databases with just one query. Entrez returns search results that can include a combination of many types of data on the query, such as nucleotide sequences, protein sequences, macromolecular structures, and related articles in the literature. Prior to the creation of Entrez, an individual might have to place one query to a nucleotide database to find a nucleotide sequence, submit another query to a structural database to find the published structure of the gene product, and submit a final query to a literature database to find citations for journal articles on the query topic. NCBI recognized the time and effort that could be saved by a tool that could cross-link these databases and integrate all information related to a given query subject into one report.View the Entrez Database page . This module contains a few problem questions, for use in a computer lab setting. The lab instructor may require that yousupply answers to these questions as an indication that you have completed the module.

The Entrez Nucleotides database includes sequences from GenBank, RefSeq, and PDB. GenBank is the National Institutes of Health (NIH) genetic sequencedatabase. GenBank, the DNA DataBank of Japan (DDBJ) and the European Molecular Biology Laboratory (EMBL) comprise the International Nucleotide SequenceDatabase Collaboration. These three organizations exchange data on a daily basis. The number of bases in the Entrez Nucleotides database currently growsat an exponential rate. Click on the Nucleotide link listed under the heading "Nucleotide Databases".

What is the number of bases stored in the Entrez nucleotide database, as of the last report?

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Use the back arrow of the browser to return to the Entrez Database web page. Locate the MMDB (Molecular Modeling DataBase), one of NCBI's structure databases and clickon the link to read about it. MMDB is a subset of three-dimensional structures obtained from the ProteinData Bank (PDB), excluding theoretical models. While the protein databases contain protein sequences, the structural database contains coordinate files (PDB files) of biological molecules with solved (known) structures.Click on the arrow next to the search box at the top of the web page and view the list of databases for selection.The literature database is accessed through PubMed, which encompasses the National Library of Medicine'sjournals database, MEDLINE, as well as providing some additional online services. MEDLINE is a collection of medical and life science journalcitations that includes articles dating back to the mid-1960's.Entrez allows access to information such as nucleotide and protein sequencesorganized by species in the NCBI taxonomy database, also found on the selection list. The connectivity of the databases available on the selection list are indicated by the diagram on the Entrez Database web page . Click on the diagram to access a Flash model of Entrez database connectivity. As long as the browser has a Flash plug-in, placing the mouse over one of the nodes representing a database will highlight its connectivity.Try this on the node labeled "Protein". Actually clicking on the node will forward the user to the database home page.

Questions & Answers

where we get a research paper on Nano chemistry....?
Maira Reply
nanopartical of organic/inorganic / physical chemistry , pdf / thesis / review
Ali
what are the products of Nano chemistry?
Maira Reply
There are lots of products of nano chemistry... Like nano coatings.....carbon fiber.. And lots of others..
learn
Even nanotechnology is pretty much all about chemistry... Its the chemistry on quantum or atomic level
learn
Google
da
no nanotechnology is also a part of physics and maths it requires angle formulas and some pressure regarding concepts
Bhagvanji
hey
Giriraj
Preparation and Applications of Nanomaterial for Drug Delivery
Hafiz Reply
revolt
da
Application of nanotechnology in medicine
what is variations in raman spectra for nanomaterials
Jyoti Reply
ya I also want to know the raman spectra
Bhagvanji
I only see partial conversation and what's the question here!
Crow Reply
what about nanotechnology for water purification
RAW Reply
please someone correct me if I'm wrong but I think one can use nanoparticles, specially silver nanoparticles for water treatment.
Damian
yes that's correct
Professor
I think
Professor
Nasa has use it in the 60's, copper as water purification in the moon travel.
Alexandre
nanocopper obvius
Alexandre
what is the stm
Brian Reply
is there industrial application of fullrenes. What is the method to prepare fullrene on large scale.?
Rafiq
industrial application...? mmm I think on the medical side as drug carrier, but you should go deeper on your research, I may be wrong
Damian
How we are making nano material?
LITNING Reply
what is a peer
LITNING Reply
What is meant by 'nano scale'?
LITNING Reply
What is STMs full form?
LITNING
scanning tunneling microscope
Sahil
how nano science is used for hydrophobicity
Santosh
Do u think that Graphene and Fullrene fiber can be used to make Air Plane body structure the lightest and strongest. Rafiq
Rafiq
what is differents between GO and RGO?
Mahi
what is simplest way to understand the applications of nano robots used to detect the cancer affected cell of human body.? How this robot is carried to required site of body cell.? what will be the carrier material and how can be detected that correct delivery of drug is done Rafiq
Rafiq
if virus is killing to make ARTIFICIAL DNA OF GRAPHENE FOR KILLED THE VIRUS .THIS IS OUR ASSUMPTION
Anam
analytical skills graphene is prepared to kill any type viruses .
Anam
Any one who tell me about Preparation and application of Nanomaterial for drug Delivery
Hafiz
what is Nano technology ?
Bob Reply
write examples of Nano molecule?
Bob
The nanotechnology is as new science, to scale nanometric
brayan
nanotechnology is the study, desing, synthesis, manipulation and application of materials and functional systems through control of matter at nanoscale
Damian
Is there any normative that regulates the use of silver nanoparticles?
Damian Reply
what king of growth are you checking .?
Renato
What fields keep nano created devices from performing or assimulating ? Magnetic fields ? Are do they assimilate ?
Stoney Reply
why we need to study biomolecules, molecular biology in nanotechnology?
Adin Reply
?
Kyle
yes I'm doing my masters in nanotechnology, we are being studying all these domains as well..
Adin
why?
Adin
what school?
Kyle
biomolecules are e building blocks of every organics and inorganic materials.
Joe
how did you get the value of 2000N.What calculations are needed to arrive at it
Smarajit Reply
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Source:  OpenStax, Bios 533 bioinformatics. OpenStax CNX. Sep 24, 2008 Download for free at http://cnx.org/content/col10152/1.16
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