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9. Which of the following codon is LEAST LIKELY to terminate protein synthesis?
A. UAG
B. UAA
C. AUG
D. UGA

10. Which of the following structures MOST LIKELY makes the 3' end of a newly synthesized mRNA molecule?
A. 5' cap
B. Pol (A) tail
C. Codons for amino acids
D. Start codon
E. Stop codon

11. Which of the following statements is LEAST LIKELY to be correct about metabolism in the mitochondria?
A. In the mitochondria, cellular respiration involves oxidation of fuels.
B. The goal of metabolism is to generate energy in the form of ATP.
C. ATP is use as energy to sustain cellular respiration in the mitochondria as well as other metabolic pathways.
D. Cellular respiration does not consumed oxygen in order to generate ATP.
E. Three pathways, the tricarboxylic acid, electron transport chain and oxidative phosphorylation, work together to generate ATP and heat.

12. Which of the following components in the electron transport chain MOST LIKELY shares the same enzyme with the tricarboxylic acid pathway?
A. Complex I: NADH dehydrogenase
B. Complex II: Succinate dehydrogenase
C. Cytochrome c
D. Complex III: cytochromes b-c1
E. Complex IV: cytochrome c oxidase

11. Which of the following statements is LESS ACCURATE about the electron transport chain?
A. Pathway responds very rapidly based on the body's needs and demands for energy (ATP).
B. Pathway uses an electrochemical gradient of protons to provide the energy necessary for ATP synthesis, transport of ions across the mitochondrial membrane and heat.
C. This pathway is reversible and electron transfer is not linked to proton pumping into the intermembrane space.
D. Pathway consists of a series of oxidation-reductions reactions carried out by a series of electron carrier complexes inside the inner membrane of the mitochondria.
E. The electrons carriers pass electrons to other complexes sequentially while pumping protons into the intermembrane space.

14. Which of the following pairs of enzymes are MOST LIKELY to cause accumulation of acids in the blood as a result of thiamine deficiency?
A. Malate dehydrogenase and citrate synthase
B. Succinate dehydrogenase and fumarase
C. Pyruvate dehydrogenase and alpha-ketoacid dehydrogenase
D. SuccinylCoA synthase and citrate synthase
E. Isocitrate dehydrogenase and aconitase
15. Which of the following classes of molecules is LESS LIKELY to feed into the tricarboxylic acid pathway to be oxidized as fuel?
A. Amino acids
B. Carbohydrates
C. Fatty Acids
D. Enzymes
E. Alcohols like ethanol
16. Which of the following chemicals is LESS LIKELY to cause damage to the central nervous system or cancer by inhibiting alpha-ketoacid dehydrogenase in the tricarboxylic acid pathway?
A. Mercury
B. Arsenate (AsO4-3)
C. Arsenite (AsO3-3)
D. NADH
17. Which of the following statements is LEAST ACCURATE about oxidative phosphorylation?
A. One full turn of the c subunits of the F0 pore releases a total of twelve protons into the mitochondrial matrix.
B. Energy from the electrochemical gradient of the electron transport chain and rotation of the asymmetric shaft of the F0 pore alters the shape of binding sites of the F1 headpiece.
C. One full term of the binding sites in the F 1 headpiece releases twelve ATP molecules.
D. The three binding sites in the F1 headpiece facilitates: binding of ADP + Pi, as well as synthesis and release of ATP.
E. The body increased needs for energy during strenuous exercise ties together oxidative phosphorylation to the electron transport chain and the tricarboxylic acid pathways.
18. In the picture below: Which of the following DNA mutations is MOST LIKELY the cause of these changes in the chromosomes?
A. Duplications
B. Deletions
C. Silent
D. Missense
E. Nonsense

19. Which of the following metabolic pathways are LESS LIKELY to use an intermediate molecule directly from the tricarboxylic acid pathway for their other own metabolism?
A. Amino acids synthesis, nucleotide synthesis and gluconeogenesis
B. Glycolysis, glycogen synthesis and pentose phosphate pathway
C. Fatty acids, steroids and neurotransmitter synthesis
D. Electron transport chain and oxidative phosphorylation
E. Porphyrin and heme synthesis

20. In this picture below, abnormal red blood cells are microcytic and hypochromic. This picture shows the result of a disorder affecting the heme synthesis and the Fe-S centers of the proteins in the electron transport chain. Which of the following disorders is MOST LIKELY to cause this appearance on a peripheral blood smear?
A. Hypoxia
B. Cyanide poisoning
C. Malaria
D. Iron deficiency
E. Hemolytic disease of the newborn

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Source:  OpenStax, Biochemistry exercises. OpenStax CNX. Apr 06, 2016 Download for free at https://legacy.cnx.org/content/col11386/1.4
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