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This 40-year-old homosexual man presented with weakness, weight loss, and painless, nonpruritic facial lesions of six weeks’duration. Similar skin changes were present over his legs and lower trunk. On physical examination, the lesions were papulopustular, round or oval, andsharply demarcated. They varied in size from a few millimeters to several centimeters. Many were umbilicated, some ulcerated, and a few crusted. Themucous membranes were normal.

142. malignant syphilis

Also known as syphilis maligna praecox and lues maligna, this is a rare but completely reversible variant of secondary syphilis.Although its incidence had been decreasing since the beginning of the 20th Century, the number of reported cases has increased of late, most of them inpatients with HIV infection. The skin lesions are pleomorphic, appear in various stages of development, and become widespread, affecting the face and scalp mostoften. They begin as papulopustules, rapidly undergo necrosis, and tend to form deep crusts. Mucous membranes are involved in about a third of the cases.Histologic examination shows dense infiltrates of plasma cells and histiocytes along with obliterative vasculitis of medium-sized vessels. Spirochetes may bevisible in the tissue sections, under dark field microscopy, or both. In addition, a reactive serologic test for syphilis, sometimes with very hightiters, is the rule.

The differential diagnosis includes fungal infection, leishmaniasis, verrucous sarcoidosis, bartonellosis, leprosy, yaws,mycosis fungoides, and pyoderma gangrenosum.

The patient shown had positive serologic tests for syphilis, and after three weeks of penicillin therapy, his skin lesions resolvedcompletely.

Questions & Answers

where we get a research paper on Nano chemistry....?
Maira Reply
what are the products of Nano chemistry?
Maira Reply
There are lots of products of nano chemistry... Like nano coatings.....carbon fiber.. And lots of others..
learn
Even nanotechnology is pretty much all about chemistry... Its the chemistry on quantum or atomic level
learn
Google
da
no nanotechnology is also a part of physics and maths it requires angle formulas and some pressure regarding concepts
Bhagvanji
hey
Giriraj
Preparation and Applications of Nanomaterial for Drug Delivery
Hafiz Reply
revolt
da
Application of nanotechnology in medicine
what is variations in raman spectra for nanomaterials
Jyoti Reply
I only see partial conversation and what's the question here!
Crow Reply
what about nanotechnology for water purification
RAW Reply
please someone correct me if I'm wrong but I think one can use nanoparticles, specially silver nanoparticles for water treatment.
Damian
yes that's correct
Professor
I think
Professor
Nasa has use it in the 60's, copper as water purification in the moon travel.
Alexandre
nanocopper obvius
Alexandre
what is the stm
Brian Reply
is there industrial application of fullrenes. What is the method to prepare fullrene on large scale.?
Rafiq
industrial application...? mmm I think on the medical side as drug carrier, but you should go deeper on your research, I may be wrong
Damian
How we are making nano material?
LITNING Reply
what is a peer
LITNING Reply
What is meant by 'nano scale'?
LITNING Reply
What is STMs full form?
LITNING
scanning tunneling microscope
Sahil
how nano science is used for hydrophobicity
Santosh
Do u think that Graphene and Fullrene fiber can be used to make Air Plane body structure the lightest and strongest. Rafiq
Rafiq
what is differents between GO and RGO?
Mahi
what is simplest way to understand the applications of nano robots used to detect the cancer affected cell of human body.? How this robot is carried to required site of body cell.? what will be the carrier material and how can be detected that correct delivery of drug is done Rafiq
Rafiq
if virus is killing to make ARTIFICIAL DNA OF GRAPHENE FOR KILLED THE VIRUS .THIS IS OUR ASSUMPTION
Anam
analytical skills graphene is prepared to kill any type viruses .
Anam
Any one who tell me about Preparation and application of Nanomaterial for drug Delivery
Hafiz
what is Nano technology ?
Bob Reply
write examples of Nano molecule?
Bob
The nanotechnology is as new science, to scale nanometric
brayan
nanotechnology is the study, desing, synthesis, manipulation and application of materials and functional systems through control of matter at nanoscale
Damian
Is there any normative that regulates the use of silver nanoparticles?
Damian Reply
what king of growth are you checking .?
Renato
What fields keep nano created devices from performing or assimulating ? Magnetic fields ? Are do they assimilate ?
Stoney Reply
why we need to study biomolecules, molecular biology in nanotechnology?
Adin Reply
?
Kyle
yes I'm doing my masters in nanotechnology, we are being studying all these domains as well..
Adin
why?
Adin
what school?
Kyle
biomolecules are e building blocks of every organics and inorganic materials.
Joe
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Source:  OpenStax, Images of memorable cases: 50 years at the bedside. OpenStax CNX. Dec 08, 2008 Download for free at http://cnx.org/content/col10449/1.7
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