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This 40-year-old homosexual man presented with weakness, weight loss, and painless, nonpruritic facial lesions of six weeks’duration. Similar skin changes were present over his legs and lower trunk. On physical examination, the lesions were papulopustular, round or oval, andsharply demarcated. They varied in size from a few millimeters to several centimeters. Many were umbilicated, some ulcerated, and a few crusted. Themucous membranes were normal.

142. malignant syphilis

Also known as syphilis maligna praecox and lues maligna, this is a rare but completely reversible variant of secondary syphilis.Although its incidence had been decreasing since the beginning of the 20th Century, the number of reported cases has increased of late, most of them inpatients with HIV infection. The skin lesions are pleomorphic, appear in various stages of development, and become widespread, affecting the face and scalp mostoften. They begin as papulopustules, rapidly undergo necrosis, and tend to form deep crusts. Mucous membranes are involved in about a third of the cases.Histologic examination shows dense infiltrates of plasma cells and histiocytes along with obliterative vasculitis of medium-sized vessels. Spirochetes may bevisible in the tissue sections, under dark field microscopy, or both. In addition, a reactive serologic test for syphilis, sometimes with very hightiters, is the rule.

The differential diagnosis includes fungal infection, leishmaniasis, verrucous sarcoidosis, bartonellosis, leprosy, yaws,mycosis fungoides, and pyoderma gangrenosum.

The patient shown had positive serologic tests for syphilis, and after three weeks of penicillin therapy, his skin lesions resolvedcompletely.

Questions & Answers

what is the stm
Brian Reply
is there industrial application of fullrenes. What is the method to prepare fullrene on large scale.?
industrial application...? mmm I think on the medical side as drug carrier, but you should go deeper on your research, I may be wrong
How we are making nano material?
what is a peer
What is meant by 'nano scale'?
What is STMs full form?
scanning tunneling microscope
how nano science is used for hydrophobicity
Do u think that Graphene and Fullrene fiber can be used to make Air Plane body structure the lightest and strongest. Rafiq
what is differents between GO and RGO?
what is simplest way to understand the applications of nano robots used to detect the cancer affected cell of human body.? How this robot is carried to required site of body cell.? what will be the carrier material and how can be detected that correct delivery of drug is done Rafiq
what is Nano technology ?
Bob Reply
write examples of Nano molecule?
The nanotechnology is as new science, to scale nanometric
nanotechnology is the study, desing, synthesis, manipulation and application of materials and functional systems through control of matter at nanoscale
Is there any normative that regulates the use of silver nanoparticles?
Damian Reply
what king of growth are you checking .?
What fields keep nano created devices from performing or assimulating ? Magnetic fields ? Are do they assimilate ?
Stoney Reply
why we need to study biomolecules, molecular biology in nanotechnology?
Adin Reply
yes I'm doing my masters in nanotechnology, we are being studying all these domains as well..
what school?
biomolecules are e building blocks of every organics and inorganic materials.
anyone know any internet site where one can find nanotechnology papers?
Damian Reply
sciencedirect big data base
Introduction about quantum dots in nanotechnology
Praveena Reply
what does nano mean?
Anassong Reply
nano basically means 10^(-9). nanometer is a unit to measure length.
do you think it's worthwhile in the long term to study the effects and possibilities of nanotechnology on viral treatment?
Damian Reply
absolutely yes
how to know photocatalytic properties of tio2 nanoparticles...what to do now
Akash Reply
it is a goid question and i want to know the answer as well
characteristics of micro business
for teaching engĺish at school how nano technology help us
How can I make nanorobot?
Do somebody tell me a best nano engineering book for beginners?
s. Reply
there is no specific books for beginners but there is book called principle of nanotechnology
how can I make nanorobot?
what is fullerene does it is used to make bukky balls
Devang Reply
are you nano engineer ?
fullerene is a bucky ball aka Carbon 60 molecule. It was name by the architect Fuller. He design the geodesic dome. it resembles a soccer ball.
what is the actual application of fullerenes nowadays?
That is a great question Damian. best way to answer that question is to Google it. there are hundreds of applications for buck minister fullerenes, from medical to aerospace. you can also find plenty of research papers that will give you great detail on the potential applications of fullerenes.
how did you get the value of 2000N.What calculations are needed to arrive at it
Smarajit Reply
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Source:  OpenStax, Images of memorable cases: 50 years at the bedside. OpenStax CNX. Dec 08, 2008 Download for free at http://cnx.org/content/col10449/1.7
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