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Learning objectives

  • Identify common parasites that cause infections of the circulatory and lymphatic systems
  • Compare the major characteristics of specific parasitic diseases affecting the circulatory and lymphatic systems

Some protozoa and parasitic flukes are also capable of causing infections of the human circulatory system. Although these infections are rare in the US, they continue to cause widespread suffering in the developing world today. Fungal infections of the circulatory system are very rare. Therefore, they are not discussed in this chapter.

Malaria

Despite more than a century of intense research and clinical advancements, malaria remains one of the most important infectious diseases in the world today. Its widespread distribution places more than half of the world’s population in jeopardy. In 2015, the WHO estimated there were about 214 million cases of malaria worldwide, resulting in about 438,000 deaths; about 88% of cases and 91% of deaths occurred in Africa. World Health Organization. “World Malaria Report 2015: Summary.” 2015. http://www.who.int/malaria/publications/world-malaria-report-2015/report/en/. Accessed July 28, 2016. Although malaria is not currently a major threat in the US, the possibility of its reintroduction is a concern. Malaria is caused by several protozoan parasites in the genus Plasmodium : P. falciparum, P. knowlesi, P. malariae, P. ovale, and P. vivax. Plasmodium primarily infect red blood cells and are transmitted through the bite of Anopheles mosquito es.

Currently, P. falciparum is the most common and most lethal cause of malaria, often called falciparum malaria. Falciparum malaria is widespread in highly populated regions of Africa and Asia, putting many people at risk for the most severe form of the disease.

The classic signs and symptoms of malaria are cycles of extreme fever and chills. The sudden, violent symptoms of malaria start with malaise, abrupt chills, and fever (39–41° C [102.2–105.8 °F]), rapid andfaint pulse, polyuria, headache, myalgia, nausea, and vomiting. After 2 to 6 hours of these symptoms, the fever falls, and profuse sweating occurs for 2 to 3 hours, followed by extreme fatigue. These symptoms are a result of Plasmodium emerging from red blood cells synchronously, leading to simultaneous rupture of a large number of red blood cells, resulting in damage to the spleen, liver, lymph nodes, and bone marrow. The organ damage resulting from hemolysis causes patients to develop sludge blood (i.e., blood in which the red blood cells agglutinate into clumps) that can lead to lack of oxygen, necrosis of blood vessels, organ failure, and death.

In established infections, malarial cycles of fever and chills typically occur every 2 days in the disease described as tertian malaria , which is caused by P. vivax and P. ovale . The cycles occur every 3 days in the disease described as quartan malaria , which is caused by P. malariae . These intervals may vary among cases.

Plasmodium has a complex life cycle that includes several developmental stages alternately produced in mosquitoes and humans ( [link] ). When an infected mosquito takes a blood meal, sporozoites in the mosquito salivary gland are injected into the host’s blood. These parasites circulate to the liver, where they develop into schizonts. The schizonts then undergo schizogony , resulting in the release of many merozoites at once. The merozoites move to the bloodstream and infect red blood cells. Inside red blood cells, merozoites develop into trophozoites that produce more merozoites. The synchronous release of merozoites from red blood cells in the evening leads to the symptoms of malaria.

Questions & Answers

i wante to study medicine in university so how i should prepare my self
Lissa Reply
microorganism functions
NUHU Reply
how does the helicobacteri pylori affect the stomach walls?
Erick Reply
hi
Allan
Hlo
SUMIT
hi
Umar
hi
Umar
when the stomach is been affected with helicobacteria what are the preventive measure to be considered to ensure specific outcome?
Umar
yeah
Ayan
what is microbiology
vijay Reply
microbiology is the scientific study of microorganisms .microorganisms are those organisms that are too small to see with the naked eye ex-bacteria fungi
Yashkin
a branch of biological science concerned with organisms that can not be observed with a naked eye
Mooya
what are the types of granulocytes and explain
lord
polymorpho nuclear leukocyte, known as granulocyte are divide into three,1-polymorpho eosinophil 2-polymorpho basophil 3-polymorpho neutrophil
Musa
microbiology is scientific study of microorganism which can nt be seen by naked eye,for example bacteria,viruses, protozoa ad fungi.
Emma
microbiology is the scientific study of microorganisms
Atia
I want to know more about sample collection on the field
Ama Reply
blood collection and urinarysis
Lizzy
2143
Lizzy
yes
Lizzy
In the periodic table the number on the upper left hand side is what
Aurelia Reply
Hydrogen
Tob
am not talking about the elements
Aurelia
Is it the atomic number or the mass number
Aurelia
hologen
Usman
differences between acid fast and non acid fast bacilli
ANTHONY Reply
acid fast have cell wall that holds to carbol fuschin stain while non acid fast doesn't have. it readily releases out the primary stain the carbol fuschin.
LAFIA
where do I post a question that isn't related to that topic
eklectc
hi everyone
kennedy
hello
Olivia
for sure, this question is not related to the topic.
LAFIA
can someone explain the process of glycolysis and the electron transport chain? I'm so freakin lost. it loses carbons, gains hydroxyls, gains, loses Hydrogens....ugh it's like a foreign language to me! or direct me to a youTube video or something that will make this seem easier to concept?
eklectc
it's a loaded question, sorry!
eklectc
why is DNA a genetic material
Mcbeth Reply
DNA is genetic material because it contains chromosome contains the traits which includes characters and behavioral characteristics
chima
why is it difficulty to classfy protista
Tanaka
Good
Eddy
what is infection prevention
Muhammed Reply
good hygiene
Dhaqan
way of preventing disease causing germs
henry
maintenance of sterilization
Pooja
h
Faustina
describe the components of the epidemiology triangle
Muhammed Reply
Hai
Nantongo
hii
Md
where from you
Md
i am Indian
Md
you
Md
Hello friend
effiong
How are you people doing
effiong
أ‌) Host factor ب) pathogen ج) environment
Widad
Hello
Kofi
Hi
Widad
hey hi
kalai
The epidemiologic triangle is made up of three parts: agent, host and environment
Princess
please can a microbiologist will work at hospital
Usman
what are the fluids used in biochemistry Lab used to diagnose diseases
Jb Reply
fadumo qule a gemil3
fadumo Reply
Faadum mahamud disease micro biology
fadumo
makuway diinkaraan suaalo
fadumo
history of microbiology
Balqees Reply
Penicillin is caused by what microorganism
Balqees
Penicillin is caused by what microorganism
Balqees
penicillium notatum
Pooja
M sorry I mean penicillin is caused by what Fungi
Balqees
penicillium fungi
Pooja
when I finish with my bsc in microbiology where wil I work
Usman
Why can we see ourselves in a mirror?
Usman
mention 5 characteristics of prokaryotic cell and also 5 characteristics of euryotic cell
Grace Reply
PROKARYOTES _ does not have nucleus _does not have membrane bound organels like eukaryotes -does not have endoplasmic reticulum _does not have a mitchochondrion _it have plasmid instead of chromosome EUKARYOTE S _have true nucleus _have all membrane bound organels _have mitochondria have
Pooja
continuation _have endoplasmic reticulum _have chromosomes does not have plasmid
Pooja
antigenisity define
kalai
explanation of spores
nahida Reply

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Source:  OpenStax, Microbiology. OpenStax CNX. Nov 01, 2016 Download for free at http://cnx.org/content/col12087/1.4
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