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In humans, a wide variety of viruses are capable of causing various infections and diseases. Some of the deadliest emerging pathogens in humans are viruses, yet we have few treatments or drugs to deal with viral infections, making them difficult to eradicate.

Viruses that can be transmitted from an animal host to a human host can cause zoonoses . For example, the avian influenza virus originates in birds, but can cause disease in humans. Reverse zoonoses are caused by infection of an animal by a virus that originated in a human.

Fighting bacteria with viruses

The emergence of superbugs, or multidrug resistant bacteria , has become a major challenge for pharmaceutical companies and a serious health-care problem. According to a 2013 report by the US Centers for Disease Control and Prevention (CDC), more than 2 million people are infected with drug-resistant bacteria in the US annually, resulting in at least 23,000 deaths. US Department of Health and Human Services, Centers for Disease Control and Prevention. “Antibiotic Resistance Threats in the United States, 2013.” http://www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf (accessed September 22, 2015). The continued use and overuse of antibiotics will likely lead to the evolution of even more drug-resistant strains.

One potential solution is the use of phage therapy , a procedure that uses bacteria-killing viruses (bacteriophages) to treat bacterial infections. Phage therapy is not a new idea. The discovery of bacteriophages dates back to the early 20th century, and phage therapy was first used in Europe in 1915 by the English bacteriologist Frederick Twort . M. Clokie et al. “Phages in Nature.” Bacteriophage 1, no. 1 (2011): 31–45. However, the subsequent discovery of penicillin and other antibiotics led to the near abandonment of this form of therapy, except in the former Soviet Union and a few countries in Eastern Europe. Interest in phage therapy outside of the countries of the former Soviet Union is only recently re-emerging because of the rise in antibiotic-resistant bacteria. A. Sulakvelidze et al. “Bacteriophage Therapy.” Antimicrobial Agents and Chemotherapy 45, no. 3 (2001): 649–659.

Phage therapy has some advantages over antibiotics in that phages kill only one specific bacterium, whereas antibiotics kill not only the pathogen but also beneficial bacteria of the normal microbiota. Development of new antibiotics is also expensive for drug companies and for patients, especially for those who live in countries with high poverty rates.

Phages have also been used to prevent food spoilage. In 2006, the US Food and Drug Administration approved the use of a solution containing six bacteriophages that can be sprayed on lunch meats such as bologna, ham, and turkey to kill Listeria monocytogenes , a bacterium responsible for listeriosis, a form of food poisoning. Some consumers have concerns about the use of phages on foods, however, especially given the rising popularity of organic products. Foods that have been treated with phages must declare “ bacteriophage preparation ” in the list of ingredients or include a label declaring that the meat has been “treated with antimicrobial solution to reduce microorganisms.” US Food and Drug Administration. “FDA Approval of Listeria -specific Bacteriophage Preparation on Ready-to-Eat (RTE) Meat and Poultry Products.” http://www.fda.gov/food/ingredientspackaginglabeling/ucm083572.htm (accessed September 22, 2015).

Questions & Answers

similarities between prokaryotic cell and eukaryotic cell
Ednah Reply
Eukaryotic cells contain membrane-bound organelles, including a nucleus. ... Prokaryotic cells do not contain a nucleus or any other membrane-bound organelle. Prokaryotes include two groups: bacteria and another group called archaea.
Priya
thanks
Sarpong
what is different between plasma and serum?
Alif
difference between plasma and serum is that plasma is liquid n serum is fluid
Priya
what is microbiology
Eliham
what is the diseases caused by the microorganisms
Emmanuel
both cells have plasma membrane, which services as a barrier between the inside of the cell and outside. both prokaryotes and eukaryotes have ribosomes. they receive messages from messanger RNA molecules, telling them what proteins the cell needs.
Abdinur
Thanks
Dominic
Some bacteria infection
Dominic
what is the name given to infection got from the hospital
Mukisa
Nosocomial infection
Gifty
what is the apportion
Riyaaq
what is the main functions of organelles
Ishaq
what are pathogens
Oluka Reply
any disease causing microorganism that can invade the body and cause harm
famuyiwa
hepatitis b
Oluka
what's da answer
Oluka
any diseases that course harmful to body
Musa
hepatitis is usually implementery of the liver and is commonly course by virus infection
Musa
a type of virus that causes severe illness lasting from two to six weeks it may cause massive lived necrosis and cirrhosis
famuyiwa
hepatitis B are transmitted when in contact with body fluid such as blood,semen,varginal secration that contain the hepatitis b virus
Musa
I understand necrosis,means death of all cell or injury of blood supply, but what is cirrhosis pls
Musa
sorry meant liver cirrhosis
famuyiwa
good evening all
Billy
ok liver damage
Musa
I have a question
Billy
Hey welcome all of you...i think you are discussing about Micro-organisms..what does it Micro?
Gazu
how about, scabies (bacteria) yeah can some one gist me abt it
Billy
sorry what doest it mean Micro organism?
Gazu
microorganism are minute living organisms found almost everywhere. they can be autotrophic heterotrophic or chemotrophic
famuyiwa
Tell me about enzyme kinetics
Jaypal
wowoww thanks a lot farmuyiwa Alice
Gazu
have anyone colony pigmentation of different types of bacteria such as Aeromonas, Edwardsiella, vibros,
Sadiqur
yes dear sadiqur Bacterias are live in everywhere.. .
Gazu
microorganisms are arganism that cannot been seen with 👀 until by the use of microscope
Musa
microorganisms are arganism that cannot been seen with 👀 until by the use of microscope
Musa
yhea organisms are organisms they are naked eye/can't seen by our eyes
Gazu
and scabies are one of the most common skin condition that can course itches and raches.
Musa
and also scabies are not infection, but an infestation
Musa
my Q is what is the contribution of van-leeuwenhoek in field of microbiology
Musa
Antony van leevenhoek is father of microbiology.
Jaypal
Anton Van leewun hook is discovered Microscope it's true or not? who can brief me please
Gazu
micro organisms are organism that cannot be seen with an aided eyes ,but by the use of microscope
Ssmuel
Yes.. He discover first microscope. He take 2 lence at a time and he saw the plant cells... Thus he was called father of microbiology
Jaypal
who examined water from a bathtub and discovered microbes
famuyiwa
for instance any type of Stagnant water is creat there are d/t tupes of small animals.. so those animals are called Micro organism?
Gazu
thank you javpal for Describing.
Gazu
can you please differentiate between vacuoles and inclusion bodies
Noor Reply
vacuoles consists of watery solution called cell sap while bodies are organelles
Prince
5 difference please
Noor
Archaea is an odd type of bacteria that live in extreme environments; high salt, high temperature etc. usually called extremophiles.
Danesia Reply
you know anyone that has delt with enterobacter agglomerans.
Vernon
it is a type of gram negative bacteria and its ubiquitous mostly isolated from plant stuffs and also from faecal material of animals. I heard the name pantoea . it is bacillus in structure.
Sujan
OLUKA MARTIN
Oluka
What are the classification of microorganisms
Portia Reply
Basic classification are eukaryotic and prokaryotic..
micro organisms are classified into three namely: Archaea, eukaryote and prokaryotic organisms
Blandine
Yay that's right
what is archaea
Ateeq
I've got an issue with the message view
Frank Reply
Is there any effective way to learn microbiology.
Frank Reply
I have some basic knowledge of biology. I mean i'm totally beginner in that field.
Frank
Assuming that i'm interested in neuroscience. What is the best way to master that particular subject.
Frank
Hi
Can you wait me just a minute
Iam apologies for guidance you in neuroscience.. I'm not physician.. I'm microbiologist
My pleasure to join to you
Let's begin a conversation
Frank Reply
What would be saying
?
Akram
do you know anything about microbiology
diana
I have so much studying to catch up on🙄
Britnee
any study tips
Britnee
Yas of course
What would you like to know
well i'm studying Pharmacy second year and i just started With Microbiology
diana
if you have any basics to tell us 🤷🏻‍♀️ would be helpful
diana
Yas, first you must know that you will have a very easy lecture..
In second stage you will try to learn the type of microbiology
A simple definition for microbiology
In second stage you will try to learn the type of microbiology.. you must learn the bacteria..its structure.. Classification of bacteria according to shape..
It's so easy
What triggers the natural killer cells
jenipher Reply
microbiology is the study of science which deals with study of microorganism e.g .virus,bacteria
sufian Reply
microbiology is a branch of science that deals with invisible microorganisms.
Abdinur
microbiology is the branch of science which deals with the study of organisms too small to be seen with the naked eye
Andrre
what is microbiology
Safwan Reply
history of microbiology
julie
give all details about cell
Samim Reply
Give me another names for all hypersensitivity
Don Reply
Give me the modern father of microbiology
Don
Antonie van Leeuwenhoek
RITU
Louis pasteur is father of modern microbiology Antonie van Leeuwenhoek is only the father of microbiology
Sujan
Antonie van Leeuwenhoek was the first person to observe the mos. whereas pasteur is the one who described about the vaccine , pasteurization etc.
Sujan
what is the virulence factor
mukhtar Reply
is the abilityof pathogen that cause disease
mary

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Source:  OpenStax, Microbiology. OpenStax CNX. Nov 01, 2016 Download for free at http://cnx.org/content/col12087/1.4
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