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Endothelia

The epithelial cells lining the urogenital tract, blood vessels, lymphatic vessels, and certain other tissues are known as endothelia . These tightly packed cells provide a particularly effective frontline barrier against invaders. The endothelia of the blood-brain barrier , for example, protect the central nervous system (CNS), which consists of the brain and the spinal cord. The CNS is one of the most sensitive and important areas of the body, as microbial infection of the CNS can quickly lead to serious and often fatal inflammation. The cell junctions in the blood vessels traveling through the CNS are some of the tightest and toughest in the body, preventing any transient microbes in the bloodstream from entering the CNS. This keeps the cerebrospinal fluid that surrounds and bathes the brain and spinal cord sterile under normal conditions.

  • Describe how the mucociliary escalator functions.
  • Name two places you would find endothelia.

Mechanical defenses

In addition to physical barriers that keep microbes out, the body has a number of mechanical defenses that physically remove pathogens from the body, preventing them from taking up residence. We have already discussed several examples of mechanical defenses, including the shedding of skin cells, the expulsion of mucus via the mucociliary escalator, and the excretion of feces through intestinal peristalsis. Other important examples of mechanical defenses include the flushing action of urine and tears, which both serve to carry microbes away from the body. The flushing action of urine is largely responsible for the normally sterile environment of the urinary tract, which includes the kidneys, ureters, and urinary bladder. Urine passing out of the body washes out transient microorganisms, preventing them from taking up residence. The eyes also have physical barriers and mechanical mechanisms for preventing infections. The eyelashes and eyelids prevent dust and airborne microorganisms from reaching the surface of the eye. Any microbes or debris that make it past these physical barriers may be flushed out by the mechanical action of blinking, which bathes the eye in tears, washing debris away ( [link] ).

A diagram of a person. An arrow from the eye points to a larger image that shows eyelashes, the eyelid and tear ducts. An arrow from the abdominal region shows a larger kidney are ureter. An arrow from the groin region shows a larger urethra.
Tears flush microbes away from the surface of the eye. Urine washes microbes out of the urinary tract as it passes through; as a result, the urinary system is normally sterile.
  • Name two mechanical defenses that protect the eyes.

Microbiome

In various regions of the body, resident microbiota serve as an important first-line defense against invading pathogens. Through their occupation of cellular binding sites and competition for available nutrients, the resident microbiota prevent the critical early steps of pathogen attachment and proliferation required for the establishment of an infection. For example, in the vagina , members of the resident microbiota compete with opportunistic pathogens like the yeast Candida . This competition prevents infections by limiting the availability of nutrients, thus inhibiting the growth of Candida , keeping its population in check. Similar competitions occur between the microbiota and potential pathogens on the skin, in the upper respiratory tract, and in the gastrointestinal tract. As will be discussed later in this chapter, the resident microbiota also contribute to the chemical defenses of the innate nonspecific host defenses.

The importance of the normal microbiota in host defenses is highlighted by the increased susceptibility to infectious diseases when the microbiota is disrupted or eliminated. Treatment with antibiotics can significantly deplete the normal microbiota of the gastrointestinal tract, providing an advantage for pathogenic bacteria to colonize and cause diarrheal infection. In the case of diarrhea caused by Clostridium difficile , the infection can be severe and potentially lethal. One strategy for treating C. difficile infections is fecal transplantation , which involves the transfer of fecal material from a donor (screened for potential pathogens) into the intestines of the recipient patient as a method of restoring the normal microbiota and combating C. difficile infections.

[link] provides a summary of the physical defenses discussed in this section.

Physical Defenses of Nonspecific Innate Immunity
Defense Examples Function
Cellular barriers Skin, mucous membranes, endothelial cells Deny entry to pathogens
Mechanical defenses Shedding of skin cells, mucociliary sweeping, peristalsis, flushing action of urine and tears Remove pathogens from potential sites of infection
Microbiome Resident bacteria of the skin, upper respiratory tract, gastrointestinal tract, and genitourinary tract Compete with pathogens for cellular binding sites and nutrients
  • List two ways resident microbiota defend against pathogens.

Key concepts and summary

  • Nonspecific innate immunity provides a first line of defense against infection by nonspecifically blocking entry of microbes and targeting them for destruction or removal from the body.
  • The physical defenses of innate immunity include physical barriers, mechanical actions that remove microbes and debris, and the microbiome, which competes with and inhibits the growth of pathogens.
  • The skin, mucous membranes, and endothelia throughout the body serve as physical barriers that prevent microbes from reaching potential sites of infection. Tight cell junctions in these tissues prevent microbes from passing through.
  • Microbes trapped in dead skin cells or mucus are removed from the body by mechanical actions such as shedding of skin cells, mucociliary sweeping, coughing, peristalsis , and flushing of bodily fluids (e.g., urination, tears)
  • The resident microbiota provide a physical defense by occupying available cellular binding sites and competing with pathogens for available nutrients.

Fill in the blank

The muscular contraction of the intestines that results in movement of material through the digestive tract is called ________.

peristalsis

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______ are the hair-like appendages of cells lining parts of the respiratory tract that sweep debris away from the lungs.

cilia

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Secretions that bathe and moisten the interior of the intestines are produced by _______ cells.

goblet

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Short answer

Differentiate a physical barrier from a mechanical removal mechanism and give an example of each.

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Identify some ways that pathogens can breach the physical barriers of the innate immune system.

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Questions & Answers

which of these ensure wounds healing mast cell and histamine
KANJOR Reply
histamine
Louryne
I mportance of microorganisms
azarsh Reply
microbiology is the study of micro organisms those been unicellular multicellular or acelluar
Nwakaego Reply
what is microbiology
Ebuka Reply
why study microbiology
David Reply
to know the cause of certain disease and how to cure them
Racheal
without micro, medicines in term of diagnostic and cure would be far away from realizing its objectives
Louisiaste
It's help to give the best medication.
Olayinka
Unvin Prisca the immune system
Gyabaa Reply
immune system is a complex of organ tissues and specialized cells which identify or kill the pathogens.
Mohammad
Thanks
shamim
explain to me the pathogenesis of plasmodium
Angelo
what is difference between bacillus and ecoil
Rymes Reply
similarities between prokaryotic cell and eukaryotic cell
Ednah Reply
Eukaryotic cells contain membrane-bound organelles, including a nucleus. ... Prokaryotic cells do not contain a nucleus or any other membrane-bound organelle. Prokaryotes include two groups: bacteria and another group called archaea.
Priya
thanks
Sarpong
what is different between plasma and serum?
Alif
difference between plasma and serum is that plasma is liquid n serum is fluid
Priya
what is microbiology
Eliham
what is the diseases caused by the microorganisms
Emmanuel
both cells have plasma membrane, which services as a barrier between the inside of the cell and outside. both prokaryotes and eukaryotes have ribosomes. they receive messages from messanger RNA molecules, telling them what proteins the cell needs.
Abdinur
Thanks
Dominic
Some bacteria infection
Dominic
what is the name given to infection got from the hospital
Mukisa
Nosocomial infection
Gifty
what is the apportion
Riyaaq
what is the main functions of organelles
Ishaq
what is main function of right and left side of the brain.
Theophile
Salifu. microbiology is the study of oganisms that are too small for the naked eyes to see. this include bacteria
Theophile
Cabdi. apportion is to divide or share out
Theophile
yap
bako
what is the parasitic helminths?
bako
what are pathogens
Oluka Reply
any disease causing microorganism that can invade the body and cause harm
famuyiwa
hepatitis b
Oluka
what's da answer
Oluka
any diseases that course harmful to body
Musa
hepatitis is usually implementery of the liver and is commonly course by virus infection
Musa
a type of virus that causes severe illness lasting from two to six weeks it may cause massive lived necrosis and cirrhosis
famuyiwa
hepatitis B are transmitted when in contact with body fluid such as blood,semen,varginal secration that contain the hepatitis b virus
Musa
I understand necrosis,means death of all cell or injury of blood supply, but what is cirrhosis pls
Musa
sorry meant liver cirrhosis
famuyiwa
good evening all
Billy
ok liver damage
Musa
I have a question
Billy
Hey welcome all of you...i think you are discussing about Micro-organisms..what does it Micro?
Gazu
how about, scabies (bacteria) yeah can some one gist me abt it
Billy
sorry what doest it mean Micro organism?
Gazu
microorganism are minute living organisms found almost everywhere. they can be autotrophic heterotrophic or chemotrophic
famuyiwa
Tell me about enzyme kinetics
Jaypal
wowoww thanks a lot farmuyiwa Alice
Gazu
have anyone colony pigmentation of different types of bacteria such as Aeromonas, Edwardsiella, vibros,
Sadiqur
yes dear sadiqur Bacterias are live in everywhere.. .
Gazu
microorganisms are arganism that cannot been seen with 👀 until by the use of microscope
Musa
microorganisms are arganism that cannot been seen with 👀 until by the use of microscope
Musa
yhea organisms are organisms they are naked eye/can't seen by our eyes
Gazu
and scabies are one of the most common skin condition that can course itches and raches.
Musa
and also scabies are not infection, but an infestation
Musa
my Q is what is the contribution of van-leeuwenhoek in field of microbiology
Musa
Antony van leevenhoek is father of microbiology.
Jaypal
Anton Van leewun hook is discovered Microscope it's true or not? who can brief me please
Gazu
micro organisms are organism that cannot be seen with an aided eyes ,but by the use of microscope
Ssmuel
Yes.. He discover first microscope. He take 2 lence at a time and he saw the plant cells... Thus he was called father of microbiology
Jaypal
who examined water from a bathtub and discovered microbes
famuyiwa
for instance any type of Stagnant water is creat there are d/t tupes of small animals.. so those animals are called Micro organism?
Gazu
thank you javpal for Describing.
Gazu
Hi the father of microbiology is Louis Pasteur
bako
Then the father of medical microbiology is Robert Koch
bako
can you please differentiate between vacuoles and inclusion bodies
Noor Reply
vacuoles consists of watery solution called cell sap while bodies are organelles
Prince
5 difference please
Noor
Archaea is an odd type of bacteria that live in extreme environments; high salt, high temperature etc. usually called extremophiles.
Danesia Reply
you know anyone that has delt with enterobacter agglomerans.
Vernon
it is a type of gram negative bacteria and its ubiquitous mostly isolated from plant stuffs and also from faecal material of animals. I heard the name pantoea . it is bacillus in structure.
Sujan
OLUKA MARTIN
Oluka
What are the classification of microorganisms
Portia Reply
Basic classification are eukaryotic and prokaryotic..
micro organisms are classified into three namely: Archaea, eukaryote and prokaryotic organisms
Blandine
Yay that's right
what is archaea
Ateeq
I've got an issue with the message view
Frank Reply
Is there any effective way to learn microbiology.
Frank Reply
I have some basic knowledge of biology. I mean i'm totally beginner in that field.
Frank
Assuming that i'm interested in neuroscience. What is the best way to master that particular subject.
Frank
Hi
Can you wait me just a minute
Iam apologies for guidance you in neuroscience.. I'm not physician.. I'm microbiologist
My pleasure to join to you
Practice MCQ 3

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Source:  OpenStax, Microbiology. OpenStax CNX. Nov 01, 2016 Download for free at http://cnx.org/content/col12087/1.4
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