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Tunica intima

The tunica intima    (also called the tunica interna) is composed of epithelial and connective tissue layers. Lining the tunica intima is the specialized simple squamous epithelium called the endothelium, which is continuous throughout the entire vascular system, including the lining of the chambers of the heart. Damage to this endothelial lining and exposure of blood to the collagenous fibers beneath is one of the primary causes of clot formation. Until recently, the endothelium was viewed simply as the boundary between the blood in the lumen and the walls of the vessels. Recent studies, however, have shown that it is physiologically critical to such activities as helping to regulate capillary exchange and altering blood flow. The endothelium releases local chemicals called endothelins that can constrict the smooth muscle within the walls of the vessel to increase blood pressure. Uncompensated overproduction of endothelins may contribute to hypertension (high blood pressure) and cardiovascular disease.

Next to the endothelium is the basement membrane, or basal lamina, that effectively binds the endothelium to the connective tissue. The basement membrane provides strength while maintaining flexibility, and it is permeable, allowing materials to pass through it. The thin outer layer of the tunica intima contains a small amount of areolar connective tissue that consists primarily of elastic fibers to provide the vessel with additional flexibility; it also contains some collagenous fibers to provide additional strength.

In larger arteries, there is also a thick, distinct layer of elastic fibers known as the internal elastic membrane    (also called the internal elastic lamina) at the boundary with the tunica media. Like the other components of the tunica intima, the internal elastic membrane provides structure while allowing the vessel to stretch. It is permeated with small openings that allow exchange of materials between the tunics. The internal elastic membrane is not apparent in veins. In addition, many veins, particularly in the lower limbs, contain valves formed by sections of thickened endothelium that are reinforced with connective tissue, extending into the lumen.

Under the microscope, the lumen and the entire tunica intima of a vein will appear smooth, whereas those of an artery will normally appear wavy because of the partial constriction of the smooth muscle in the tunica media, the next layer of blood vessel walls.

Tunica media

The tunica media    is the substantial middle layer of the vessel wall (see [link] ). It is generally the thickest layer in arteries, and it is much thicker in arteries than it is in veins. The tunica media consists of layers of smooth muscle supported by connective tissue that is primarily made up of elastic fibers, most of which are arranged in circular sheets. Toward the outer portion of the tunic, there are also layers of longitudinal muscle. Contraction and relaxation of the circular muscles decrease and increase the diameter of the vessel lumen, respectively. Specifically in arteries, vasoconstriction    decreases blood flow as the smooth muscle in the walls of the tunica media contracts, making the lumen narrower and increasing blood pressure. Similarly, vasodilation    increases blood flow as the smooth muscle relaxes, allowing the lumen to widen and blood pressure to drop. Both vasoconstriction and vasodilation are regulated in part by small vascular nerves, known as nervi vasorum    , or “nerves of the vessel,” that run within the walls of blood vessels. These are generally all sympathetic fibers, although some trigger vasodilation and others induce vasoconstriction, depending upon the nature of the neurotransmitter and receptors located on the target cell. Parasympathetic stimulation does trigger vasodilation as well as erection during sexual arousal in the external genitalia of both sexes. Nervous control over vessels tends to be more generalized than the specific targeting of individual blood vessels. Local controls, discussed later, account for this phenomenon. (Seek additional content for more information on these dynamic aspects of the autonomic nervous system.) Hormones and local chemicals also control blood vessels. Together, these neural and chemical mechanisms reduce or increase blood flow in response to changing body conditions, from exercise to hydration. Regulation of both blood flow and blood pressure is discussed in detail later in this chapter.

Questions & Answers

Capillary permeability
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Ramsin
Hello, I want to search about the topic, information and pictures
syncitium is the property of which of the following muscle
Shahab Reply
can I get the questions of human physiology that is present in HSC 2nd semester
Sai Reply
i now madam
irpa
ha can u please send me the PDF of questions
Sai
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Sai
me too if possible?
Ramsin
If a molecule can only pass through a membrane with the assistance of a membrane protein, but the direction of its travel is controlled only by its concentration, the process is called?
osmosis
chozen
A 52 year old woman turned her head quickly, during a tennis game and suddenly felt a sharp pain in her neck along her upper limb. Physical examination and medical imaging revealed a herniated degenerated IV disc in the cervical region of her vertebral column.
Isaac
a. What probably caused the IV disc herniation? b. What cause IV disc degeneration? c. What are the result of disc degeneration?
Isaac
b
Mirasol
Describe the neural control of erection and ejaculation.
Nana Reply
A 52 year old woman turned her head quickly, during a tennis game and suddenly felt a sharp pain in her neck along her upper limb. Physical examination and medical imaging revealed a herniated degenerated IV disc in the cervical region of her vertebral column. a)What probably caused the IV di
Isaac
a) What probably caused the IV disc herniation? b) What cause IV disc degeneration? c) What are the result of disc degeneration?
Isaac
iv disc herniation compress the nerve cause numbness tingling sensation even paralysis in severe cases...
Khawaja
explain more
DANIELLA Reply
yes
Ramzan
function of skeleton
Josiah Reply
- for movement - blood production by the bone marrow
Daniel
production of calsium and phosphorus
Juma
Shortly after childbirth, a woman consulted her physician about a tender swelling in her perineal region. 8. What fossa related the perineal swelling? 9. Describe what vessel may cause the collection of blood in the fossa after childbirth?
Isaac
what is heart
Subhajit Reply
it is the tissue..which pump blood to the all parts of body
GRAY
the heart is a conical , hollow, muscular organ which works continuously through out the life of a person ,it is about the size of a clenched fist and weighs about 300 grams and also the heart is in the chest just behind the breast bone and between the two lungs
Mary
a hollow muscular organ that pumps blood through the circulatory system by regular contractions
Johnny
is a muscular organ that pumps blood lungs and other body tissues through vessels
Nolosha
Shortly after childbirth, a woman consulted her physician about a tender swelling in her perineal region. 8. What fossa related the perineal swelling? 9. Describe what vessel may cause the collection of blood in the fossa after childbirth?
Isaac
Shortly after childbirth, a woman consulted her physician about a tender swelling in her perineal region. 8. What fossa related the perineal swelling? 9. Describe what vessel may cause the collection of blood in the fossa after childbirth?
Isaac Reply
inguinal fossa femoral vein?
Jeen
if you dont the answer by now you should seek another line of work. as a professor it is my duty to let you know about your lacking.
Arif
branches of brachial plexus
Arooj Reply
musculocutaneous, median, ulnar, axillary, and radial nerves.
Shakerah
Shortly after childbirth, a woman consulted her physician about a tender swelling in her perineal region. a.What fossa related the perineal swelling? b.Describe what vessel may cause the collection of blood in the fossa after childbirth?
Isaac
What is great Auricular nerve?
ZUBAIR Reply
it originates from the cervical plexus that provides sensory innervation to the skin.
Daniel
why it is called Auricular nerve
Amber
is any payment is needed to use this app
Suprith Reply
is it a question?
Samenjo
doubt about this app
Suprith
which lines divide the body into nine quadrant
Julius Reply
nine regions of abdomen can b marked using two horizontal & two vertical lines...the vertical lines are the mid clavicular lines taken from the mid point of each clavicle. the upper horizontal lines is the subcostal line taken from the inferior parts of the lowest costal cartilage...
Khawaja
to get a better understanding for the function
Rashana Reply
anatomy and physiology work closely together
Rashana
anatomy to you about the structure of the while physiology is the the study of the body function
Rashana
what is the difference between negative and positive feedback
Rashana
The key difference bewteen positive and negative feedback is their response to change. Positive feedback amplifies change while negative reduces change.
ladychen
negative feed back produces a response that brings back to normal while positive feed back produces a response that stimulates
Julius
examples of the body structure
Naki Reply
body's structure
Naki

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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