<< Chapter < Page Chapter >> Page >

Internal respiration

Internal respiration is gas exchange that occurs at the level of body tissues ( [link] ). Similar to external respiration, internal respiration also occurs as simple diffusion due to a partial pressure gradient. However, the partial pressure gradients are opposite of those present at the respiratory membrane. The partial pressure of oxygen in tissues is low, about 40 mm Hg, because oxygen is continuously used for cellular respiration. In contrast, the partial pressure of oxygen in the blood is about 100 mm Hg. This creates a pressure gradient that causes oxygen to dissociate from hemoglobin, diffuse out of the blood, cross the interstitial space, and enter the tissue. Hemoglobin that has little oxygen bound to it loses much of its brightness, so that blood returning to the heart is more burgundy in color.

Considering that cellular respiration continuously produces carbon dioxide, the partial pressure of carbon dioxide is lower in the blood than it is in the tissue, causing carbon dioxide to diffuse out of the tissue, cross the interstitial fluid, and enter the blood. It is then carried back to the lungs either bound to hemoglobin, dissolved in plasma, or in a converted form. By the time blood returns to the heart, the partial pressure of oxygen has returned to about 40 mm Hg, and the partial pressure of carbon dioxide has returned to about 45 mm Hg. The blood is then pumped back to the lungs to be oxygenated once again during external respiration.

Internal respiration

This diagram details the pathway of internal respiration. The exchange of oxygen and carbon dioxide between a red blood cell and a tissue cell is shown.
Oxygen diffuses out of the capillary and into cells, whereas carbon dioxide diffuses out of cells and into the capillary.

Everyday connection

Hyperbaric chamber treatment

A type of device used in some areas of medicine that exploits the behavior of gases is hyperbaric chamber treatment. A hyperbaric chamber is a unit that can be sealed and expose a patient to either 100 percent oxygen with increased pressure or a mixture of gases that includes a higher concentration of oxygen than normal atmospheric air, also at a higher partial pressure than the atmosphere. There are two major types of chambers: monoplace and multiplace. Monoplace chambers are typically for one patient, and the staff tending to the patient observes the patient from outside of the chamber ( [link] ). Some facilities have special monoplace hyperbaric chambers that allow multiple patients to be treated at once, usually in a sitting or reclining position, to help ease feelings of isolation or claustrophobia. Multiplace chambers are large enough for multiple patients to be treated at one time, and the staff attending these patients is present inside the chamber. In a multiplace chamber, patients are often treated with air via a mask or hood, and the chamber is pressurized.

Hyperbaric chamber

This photo shows two hyperbaric chambers.
(credit: “komunews”/flickr.com)

Hyperbaric chamber treatment is based on the behavior of gases. As you recall, gases move from a region of higher partial pressure to a region of lower partial pressure. In a hyperbaric chamber, the atmospheric pressure is increased, causing a greater amount of oxygen than normal to diffuse into the bloodstream of the patient. Hyperbaric chamber therapy is used to treat a variety of medical problems, such as wound and graft healing, anaerobic bacterial infections, and carbon monoxide poisoning. Exposure to and poisoning by carbon monoxide is difficult to reverse, because hemoglobin’s affinity for carbon monoxide is much stronger than its affinity for oxygen, causing carbon monoxide to replace oxygen in the blood. Hyperbaric chamber therapy can treat carbon monoxide poisoning, because the increased atmospheric pressure causes more oxygen to diffuse into the bloodstream. At this increased pressure and increased concentration of oxygen, carbon monoxide is displaced from hemoglobin. Another example is the treatment of anaerobic bacterial infections, which are created by bacteria that cannot or prefer not to live in the presence of oxygen. An increase in blood and tissue levels of oxygen helps to kill the anaerobic bacteria that are responsible for the infection, as oxygen is toxic to anaerobic bacteria. For wounds and grafts, the chamber stimulates the healing process by increasing energy production needed for repair. Increasing oxygen transport allows cells to ramp up cellular respiration and thus ATP production, the energy needed to build new structures.

Chapter review

The behavior of gases can be explained by the principles of Dalton’s law and Henry’s law, both of which describe aspects of gas exchange. Dalton’s law states that each specific gas in a mixture of gases exerts force (its partial pressure) independently of the other gases in the mixture. Henry’s law states that the amount of a specific gas that dissolves in a liquid is a function of its partial pressure. The greater the partial pressure of a gas, the more of that gas will dissolve in a liquid, as the gas moves toward equilibrium. Gas molecules move down a pressure gradient; in other words, gas moves from a region of high pressure to a region of low pressure. The partial pressure of oxygen is high in the alveoli and low in the blood of the pulmonary capillaries. As a result, oxygen diffuses across the respiratory membrane from the alveoli into the blood. In contrast, the partial pressure of carbon dioxide is high in the pulmonary capillaries and low in the alveoli. Therefore, carbon dioxide diffuses across the respiratory membrane from the blood into the alveoli. The amount of oxygen and carbon dioxide that diffuses across the respiratory membrane is similar.

Ventilation is the process that moves air into and out of the alveoli, and perfusion affects the flow of blood in the capillaries. Both are important in gas exchange, as ventilation must be sufficient to create a high partial pressure of oxygen in the alveoli. If ventilation is insufficient and the partial pressure of oxygen drops in the alveolar air, the capillary is constricted and blood flow is redirected to alveoli with sufficient ventilation. External respiration refers to gas exchange that occurs in the alveoli, whereas internal respiration refers to gas exchange that occurs in the tissue. Both are driven by partial pressure differences.

Questions & Answers

Functions of the thoracic cage
Fereh Reply
protect all the organs and tissues from any impact or injury
Javier
why sickle cell carrier people don't get malaria
Boakye Reply
What is the amniotic fluid
bollywood Reply
structure of heart and it's function (10 mark )
Priyanka Reply
What is the best book on physiology?
cesar Reply
describe varicocele
malulu
what do you mean by peritoneum
Siba Reply
It is thick covering surrounding the abdomen
Awais
r8
how to become good in Anatomy and physiology
malulu
hi
Milkah
hlo
Wani
What are is the last solution to abdomen pain in pregnant women
Umoru
no it is in kidney
Tantray
Kk
Umoru
structure of heart and it's function
Priyanka
Serous membrane lining the cavity of the abdomen
bollywood
it is four lobs structure and it is triangular in shaped. it 's function pumping the blood
ABDULLAH
explain root of lungs
ABDULLAH
Glomerular pressure -capsule pressure -colloid osmosis pressure
malulu Reply
how to describe mechanism of micturition
malulu
spleen is important?
AKASH Reply
helpful in destruction of rbc
It is imp in storing blood and destruction of microbes and harmful particles
Awais
ty sir
AKASH
K
Umoru
what are the sources of glucose in the body
malulu
describe mechanism of micturition
malulu
Pancreatic hormones with function
mami Reply
Insulin, which helps to regulate our blood sugar levels.
Bb
glucagon which is antagonistic to insulin increase the blood glucose level,. Somatostatin help to regulate the levels of both insulin and glucagon
Ashish
thnks for helping
nimco
thanks
Narendra
what is a lymph node.?
AKASH
lymph nodes are small kidney shaped organs of the lymphatic system.
Trishauna
there are several hundred lymph nodes found mostly throughout the thorax and abdomen of the body with the highest concentrations in the auxiliary (armpit) and inguinal groin regions.
Trishauna
what is life
Yar Reply
life is the existence of an individual human being animal or plant
Furmose
how I join this
Ahmed
meaning
Furmose
to day I am new person and I can't participate questions so to morow I shall participate question sopleas excuse me
Ahmed
I had a debate earlier about nutrition and it didn't get a clear answer on that,can one tell me what the definition of nutrition.?
kelvin
the nutrition is nourish person is feeling an nutrition
Ahmed
I think nutrition is the process of taking food and using it for growth, metabolism and repair.
Methila
life is full of happy and sorrow
Sanamacha
life is achievement
Nandini
life is the nothing but god gave us 1 body. and we all service k in this body. The things which we do for the Survivation for this body I felt that this is called as the life
AKASH
Yes God gave us life but not god who gave us the life. Hope u understood what i meant by God n not god who gave life..... ?
laku
What's the question?
Sherman Reply
once you lose pigmentation can you ever get it back
Shannon Reply
s
Nandini
females are lesser prone to acne
Ritika Reply
why please expain
Janvi
described the skin
Yayra Reply
skin is outer covery of human body and it is largest organ of human body. it do three fauntion protection regulation and sensation of human body that is men fauntion of human skin it has seven part.
ABDULLAH
how thick is the epidermis?
Sovilace
the integumentary system is the largest system of the body 16% of body weight and 1.5 to 2m² in area
Trishauna
function of the endocrine system
Hamo Reply
produces hormones that plays specific functions
has endocrine gland calld as ductless gland so as produces hormones

Get the best Anatomy & Physiology course in your pocket!





Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
Google Play and the Google Play logo are trademarks of Google Inc.

Notification Switch

Would you like to follow the 'Anatomy & Physiology' conversation and receive update notifications?

Ask