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Shape of red blood cells

This photograph shows a few red blood cells.
Erythrocytes are biconcave discs with very shallow centers. This shape optimizes the ratio of surface area to volume, facilitating gas exchange. It also enables them to fold up as they move through narrow blood vessels.

Hemoglobin

Hemoglobin is a large molecule made up of proteins and iron. It consists of four folded chains of a protein called globin    , designated alpha 1 and 2, and beta 1 and 2 ( [link] a ). Each of these globin molecules is bound to a red pigment molecule called heme    , which contains an ion of iron (Fe 2+ ) ( [link] b ).

Hemoglobin

This figure shows the structure of hemoglobin. The left panel shows the protein structure and the right panel shows the chemical formula.
(a) A molecule of hemoglobin contains four globin proteins, each of which is bound to one molecule of the iron-containing pigment heme. (b) A single erythrocyte can contain 300 million hemoglobin molecules, and thus more than 1 billion oxygen molecules.

Each iron ion in the heme can bind to one oxygen molecule; therefore, each hemoglobin molecule can transport four oxygen molecules. An individual erythrocyte may contain about 300 million hemoglobin molecules, and therefore can bind to and transport up to 1.2 billion oxygen molecules (see [link] b ).

In the lungs, hemoglobin picks up oxygen, which binds to the iron ions, forming oxyhemoglobin    . The bright red, oxygenated hemoglobin travels to the body tissues, where it releases some of the oxygen molecules, becoming darker red deoxyhemoglobin    , sometimes referred to as reduced hemoglobin. Oxygen release depends on the need for oxygen in the surrounding tissues, so hemoglobin rarely if ever leaves all of its oxygen behind. In the capillaries, carbon dioxide enters the bloodstream. About 76 percent dissolves in the plasma, some of it remaining as dissolved CO 2 , and the remainder forming bicarbonate ion. About 23–24 percent of it binds to the amino acids in hemoglobin, forming a molecule known as carbaminohemoglobin    . From the capillaries, the hemoglobin carries carbon dioxide back to the lungs, where it releases it for exchange of oxygen.

Changes in the levels of RBCs can have significant effects on the body’s ability to effectively deliver oxygen to the tissues. Ineffective hematopoiesis results in insufficient numbers of RBCs and results in one of several forms of anemia. An overproduction of RBCs produces a condition called polycythemia. The primary drawback with polycythemia is not a failure to directly deliver enough oxygen to the tissues, but rather the increased viscosity of the blood, which makes it more difficult for the heart to circulate the blood.

In patients with insufficient hemoglobin, the tissues may not receive sufficient oxygen, resulting in another form of anemia. In determining oxygenation of tissues, the value of greatest interest in healthcare is the percent saturation; that is, the percentage of hemoglobin sites occupied by oxygen in a patient’s blood. Clinically this value is commonly referred to simply as “percent sat.”

Percent saturation is normally monitored using a device known as a pulse oximeter, which is applied to a thin part of the body, typically the tip of the patient’s finger. The device works by sending two different wavelengths of light (one red, the other infrared) through the finger and measuring the light with a photodetector as it exits. Hemoglobin absorbs light differentially depending upon its saturation with oxygen. The machine calibrates the amount of light received by the photodetector against the amount absorbed by the partially oxygenated hemoglobin and presents the data as percent saturation. Normal pulse oximeter readings range from 95–100 percent. Lower percentages reflect hypoxemia    , or low blood oxygen. The term hypoxia is more generic and simply refers to low oxygen levels. Oxygen levels are also directly monitored from free oxygen in the plasma typically following an arterial stick. When this method is applied, the amount of oxygen present is expressed in terms of partial pressure of oxygen or simply pO 2 and is typically recorded in units of millimeters of mercury, mm Hg.

Questions & Answers

Capillary permeability
what do you want to know about it?
Ramsin
Hello, I want to search about the topic, information and pictures
syncitium is the property of which of the following muscle
Shahab Reply
can I get the questions of human physiology that is present in HSC 2nd semester
Sai Reply
i now madam
irpa
ha can u please send me the PDF of questions
Sai
it's important to me to have that information please send as fast as u can
Sai
me too if possible?
Ramsin
If a molecule can only pass through a membrane with the assistance of a membrane protein, but the direction of its travel is controlled only by its concentration, the process is called?
osmosis
chozen
A 52 year old woman turned her head quickly, during a tennis game and suddenly felt a sharp pain in her neck along her upper limb. Physical examination and medical imaging revealed a herniated degenerated IV disc in the cervical region of her vertebral column.
Isaac
a. What probably caused the IV disc herniation? b. What cause IV disc degeneration? c. What are the result of disc degeneration?
Isaac
b
Mirasol
Describe the neural control of erection and ejaculation.
Nana Reply
A 52 year old woman turned her head quickly, during a tennis game and suddenly felt a sharp pain in her neck along her upper limb. Physical examination and medical imaging revealed a herniated degenerated IV disc in the cervical region of her vertebral column. a)What probably caused the IV di
Isaac
a) What probably caused the IV disc herniation? b) What cause IV disc degeneration? c) What are the result of disc degeneration?
Isaac
iv disc herniation compress the nerve cause numbness tingling sensation even paralysis in severe cases...
Khawaja
explain more
DANIELLA Reply
yes
Ramzan
function of skeleton
Josiah Reply
- for movement - blood production by the bone marrow
Daniel
production of calsium and phosphorus
Juma
Shortly after childbirth, a woman consulted her physician about a tender swelling in her perineal region. 8. What fossa related the perineal swelling? 9. Describe what vessel may cause the collection of blood in the fossa after childbirth?
Isaac
what is heart
Subhajit Reply
it is the tissue..which pump blood to the all parts of body
GRAY
the heart is a conical , hollow, muscular organ which works continuously through out the life of a person ,it is about the size of a clenched fist and weighs about 300 grams and also the heart is in the chest just behind the breast bone and between the two lungs
Mary
a hollow muscular organ that pumps blood through the circulatory system by regular contractions
Johnny
is a muscular organ that pumps blood lungs and other body tissues through vessels
Nolosha
Shortly after childbirth, a woman consulted her physician about a tender swelling in her perineal region. 8. What fossa related the perineal swelling? 9. Describe what vessel may cause the collection of blood in the fossa after childbirth?
Isaac
Shortly after childbirth, a woman consulted her physician about a tender swelling in her perineal region. 8. What fossa related the perineal swelling? 9. Describe what vessel may cause the collection of blood in the fossa after childbirth?
Isaac Reply
inguinal fossa femoral vein?
Jeen
if you dont the answer by now you should seek another line of work. as a professor it is my duty to let you know about your lacking.
Arif
branches of brachial plexus
Arooj Reply
musculocutaneous, median, ulnar, axillary, and radial nerves.
Shakerah
Shortly after childbirth, a woman consulted her physician about a tender swelling in her perineal region. a.What fossa related the perineal swelling? b.Describe what vessel may cause the collection of blood in the fossa after childbirth?
Isaac
What is great Auricular nerve?
ZUBAIR Reply
it originates from the cervical plexus that provides sensory innervation to the skin.
Daniel
why it is called Auricular nerve
Amber
is any payment is needed to use this app
Suprith Reply
is it a question?
Samenjo
doubt about this app
Suprith
which lines divide the body into nine quadrant
Julius Reply
nine regions of abdomen can b marked using two horizontal & two vertical lines...the vertical lines are the mid clavicular lines taken from the mid point of each clavicle. the upper horizontal lines is the subcostal line taken from the inferior parts of the lowest costal cartilage...
Khawaja
to get a better understanding for the function
Rashana Reply
anatomy and physiology work closely together
Rashana
anatomy to you about the structure of the while physiology is the the study of the body function
Rashana
what is the difference between negative and positive feedback
Rashana
The key difference bewteen positive and negative feedback is their response to change. Positive feedback amplifies change while negative reduces change.
ladychen
negative feed back produces a response that brings back to normal while positive feed back produces a response that stimulates
Julius
examples of the body structure
Naki Reply
body's structure
Naki

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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