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This photo shows Drosophila that has normal antennae on its head, and a mutant that has legs on its head.
As seen in comparing the wild-type Drosophila (left) and the Antennapedia mutant (right), the Antennapedia mutant has legs on its head in place of antennae.

Evolution connection

Multiple alleles confer drug resistance in the malaria parasite

Malaria is a parasitic disease in humans that is transmitted by infected female mosquitoes, including Anopheles gambiae ( [link] a ), and is characterized by cyclic high fevers, chills, flu-like symptoms, and severe anemia. Plasmodium falciparum and P. vivax are the most common causative agents of malaria, and P. falciparum is the most deadly ( [link] b ) . When promptly and correctly treated, P. falciparum malaria has a mortality rate of 0.1 percent. However, in some parts of the world, the parasite has evolved resistance to commonly used malaria treatments, so the most effective malarial treatments can vary by geographic region.

Photo a shows the Anopheles gambiae mosquito, which carries malaria. Photo b shows a micrograph of sickle-shaped Plasmodium falciparum, the parasite that causes malaria. The Plasmodium is about 0.75 microns across.
The (a) Anopheles gambiae , or African malaria mosquito, acts as a vector in the transmission to humans of the malaria-causing parasite (b) Plasmodium falciparum , here visualized using false-color transmission electron microscopy. (credit a: James D. Gathany; credit b: Ute Frevert; false color by Margaret Shear; scale-bar data from Matt Russell)

In Southeast Asia, Africa, and South America, P. falciparum has developed resistance to the anti-malarial drugs chloroquine, mefloquine, and sulfadoxine-pyrimethamine. P. falciparum , which is haploid during the life stage in which it is infectious to humans, has evolved multiple drug-resistant mutant alleles of the dhps gene. Varying degrees of sulfadoxine resistance are associated with each of these alleles. Being haploid, P. falciparum needs only one drug-resistant allele to express this trait.

In Southeast Asia, different sulfadoxine-resistant alleles of the dhps gene are localized to different geographic regions. This is a common evolutionary phenomenon that occurs because drug-resistant mutants arise in a population and interbreed with other P. falciparum isolates in close proximity. Sulfadoxine-resistant parasites cause considerable human hardship in regions where this drug is widely used as an over-the-counter malaria remedy. As is common with pathogens that multiply to large numbers within an infection cycle, P. falciparum evolves relatively rapidly (over a decade or so) in response to the selective pressure of commonly used anti-malarial drugs. For this reason, scientists must constantly work to develop new drugs or drug combinations to combat the worldwide malaria burden.

Sumiti Vinayak, et al., “Origin and Evolution of Sulfadoxine Resistant Plasmodium falciparum ,” Public Library of Science Pathogens 6, no. 3 (2010): e1000830, doi:10.1371/journal.ppat.1000830.

X-linked traits

In humans, as well as in many other animals and some plants, the sex of the individual is determined by sex chromosomes. The sex chromosomes are one pair of non-homologous chromosomes. Until now, we have only considered inheritance patterns among non-sex chromosomes, or autosomes    . In addition to 22 homologous pairs of autosomes, human females have a homologous pair of X chromosomes, whereas human males have an XY chromosome pair. Although the Y chromosome contains a small region of similarity to the X chromosome so that they can pair during meiosis, the Y chromosome is much shorter and contains many fewer genes. When a gene being examined is present on the X chromosome, but not on the Y chromosome, it is said to be X-linked    .

Questions & Answers

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Memiru
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Rorisang
what is meant by submicroscopic?
anji Reply
what is anabolic and catabolic
Jonathan
hi
Alpha
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Memiru
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Memiru
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Dorathy Reply
biology is scientific study of living things
GUYO
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Mabiya Reply
it is a cell structure that contains DNA histones protein and other structural proteins
Ekechi
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liver is an organ in the body that meterbolise nutrients and produce bile.
Ekechi
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Eric Reply
Biology is you
muayad
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Suzette
biology is the study of living things and none living things
Ekechi
study of living organisms
anji
The mamalian endoskeleton has 206 bones
kaazim Reply
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Hannah
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Suzette
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Hannah
good thanks
Suzette
have you done the actual course?
Suzette
How many bones do human body have?
moses Reply
I don't know please help me
Kisito
206
Waneh
206
Moses
206
anji
what are these geneti materials
ONELIA Reply
Name five parts of female reproductive system and state the function of each part
Angel Reply
What is biology
Angel
What is biology
Angel
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ketchem
Ok
Angel
Name five parts of female reproductive system and state the function of each part
Angel
What is the meaning of respiration
Idriss Reply
the act or process of breathing .
Suzette
the process is very long as I know
Idriss
do you want more details ?
Suzette
yes offcourse
Smiso
what does the term diploid and haploid mean?
ONELIA
what is virgina
Shebas Reply
A female reproductive organs
Julius
fuvu LA binadam linamifupa mingapi?
Hamis Reply
explain dicot n monocot plant
Henry Reply
Di= 2cotiledon mono=cotiledon
muayad
Mono = 1 cotiledon
muayad
what is virginia
Shebas
A Virginia is a part of a female ,the passage of a child during child birth, receiver of the penis and the passage of menstral flow
Idriss
what is biology
Hassan Reply
what is liver
Hassan
Biology is the study of living organisms
Gifty
is the study of life of living organisms
Chansa
study all about organisms like their reproduction, evolution , behaviour Physiology, etc
Ubaid
this is what we call "life"@
Chansa
is the study of living organisms on earth
okubasu
It is the study of living organism
Idriss
Biology is the study of all living organisms
ketchem
what is copulation
ketchem

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Source:  OpenStax, Biology. OpenStax CNX. Feb 29, 2016 Download for free at http://cnx.org/content/col11448/1.10
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