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This report summarizes work done as part of the Hippocampus Neuroscience PFUG under Rice University's VIGRE program. VIGRE is a program of Vertically Integrated Grants for Research and Education in the Mathematical Sciences under the direction of the National Science Foundation. A PFUG is a group of Postdocs, Faculty, Undergraduates and Graduate students formed round the study of a common problem.This module reproduces the work of A Lansner and E Fransen's "Modelling Hebbian cell assemblies comprised of cortical neurons". This work was studied in the Rice University VIGRE class CAAM 499 in the Fall of 2007.

Theory

One hypothesis on how ideas are structured in the brain is that groups of cells form a unit called a cell assembly. The cells within the assembly are connected with strong excitatory synapses. Thus, when enough activity occurs in the neurons within the assembly, then the entire assembly will have the ability to activate. An active assembly would meet the definition that the cells within the assembly are firing at a high rate in the same time frame. Successions of assembly activation could be the basis of how to form thoughts and give a mental representation for different concepts. This idea was introduced by Donald Hebb in The Organization of Behavior . The assembly will eventually shut down if the source of stimulation ceases or a competing assembly can provide inhibition. This theory can be extended to explain how learning occurs and possible phenomena such as perspective-rivalry. For instance, in optical illusions, such as the nectar cube shown below, there are two different possible interpretations of the perspective. It is possible that two different assemblies represent the different perspectives. In order to switch perspectives one must shut down the current perspective assembly and activate the alternate perspective. There could also be a hierarchy of assemblies. Sub-assemblies could give rise to larger assemblies. Due to synaptic plasticity different sub-assemblies that are activated in similar orders through repetition allows new larger Assemblies to form. If sufficient clues that are represented by smaller sub-assemblies are activated, the brain will be able to activate the larger assembly.

The Neckar Cube has two possible perspectives. Cell Assembly rivalry could be responsible for competing interpretations.

Module goal

To get some insight on whether this is plausible we want to construct biologically accurate computational models and test assembly activation and inhibition. This module will follow the paper Modeling Hebbian cell assemblies comprised of cortical neurons , by A Lanser and E Fransen. It will show how to reproduce the results contained in the paper and the mathematics involved.

Here is a brief summary of what is ahead:

1.) Go over the neuron models and the different ion channels.

2.) Show how synaptic input is modeled.

3.) Show how differential equations are solved with time stepping.

4.) Show how patterns which represent different assemblies are used to "train" a network and produce weights.

Questions & Answers

what is math number
Tric Reply
x-2y+3z=-3 2x-y+z=7 -x+3y-z=6
Sidiki Reply
Need help solving this problem (2/7)^-2
Simone Reply
x+2y-z=7
Sidiki
what is the coefficient of -4×
Mehri Reply
-1
Shedrak
the operation * is x * y =x + y/ 1+(x × y) show if the operation is commutative if x × y is not equal to -1
Alfred Reply
An investment account was opened with an initial deposit of $9,600 and earns 7.4% interest, compounded continuously. How much will the account be worth after 15 years?
Kala Reply
lim x to infinity e^1-e^-1/log(1+x)
given eccentricity and a point find the equiation
Moses Reply
12, 17, 22.... 25th term
Alexandra Reply
12, 17, 22.... 25th term
Akash
College algebra is really hard?
Shirleen Reply
Absolutely, for me. My problems with math started in First grade...involving a nun Sister Anastasia, bad vision, talking & getting expelled from Catholic school. When it comes to math I just can't focus and all I can hear is our family silverware banging and clanging on the pink Formica table.
Carole
I'm 13 and I understand it great
AJ
I am 1 year old but I can do it! 1+1=2 proof very hard for me though.
Atone
hi
Adu
Not really they are just easy concepts which can be understood if you have great basics. I am 14 I understood them easily.
Vedant
find the 15th term of the geometric sequince whose first is 18 and last term of 387
Jerwin Reply
I know this work
salma
The given of f(x=x-2. then what is the value of this f(3) 5f(x+1)
virgelyn Reply
hmm well what is the answer
Abhi
If f(x) = x-2 then, f(3) when 5f(x+1) 5((3-2)+1) 5(1+1) 5(2) 10
Augustine
how do they get the third part x = (32)5/4
kinnecy Reply
make 5/4 into a mixed number, make that a decimal, and then multiply 32 by the decimal 5/4 turns out to be
AJ
how
Sheref
can someone help me with some logarithmic and exponential equations.
Jeffrey Reply
sure. what is your question?
ninjadapaul
20/(×-6^2)
Salomon
okay, so you have 6 raised to the power of 2. what is that part of your answer
ninjadapaul
I don't understand what the A with approx sign and the boxed x mean
ninjadapaul
it think it's written 20/(X-6)^2 so it's 20 divided by X-6 squared
Salomon
I'm not sure why it wrote it the other way
Salomon
I got X =-6
Salomon
ok. so take the square root of both sides, now you have plus or minus the square root of 20= x-6
ninjadapaul
oops. ignore that.
ninjadapaul
so you not have an equal sign anywhere in the original equation?
ninjadapaul
hmm
Abhi
is it a question of log
Abhi
🤔.
Abhi
I rally confuse this number And equations too I need exactly help
salma
But this is not salma it's Faiza live in lousvile Ky I garbage this so I am going collage with JCTC that the of the collage thank you my friends
salma
Commplementary angles
Idrissa Reply
hello
Sherica
im all ears I need to learn
Sherica
right! what he said ⤴⤴⤴
Tamia
hii
Uday
hi
salma
hi
Ayuba
Hello
opoku
hi
Ali
greetings from Iran
Ali
salut. from Algeria
Bach
hi
Nharnhar
A soccer field is a rectangle 130 meters wide and 110 meters long. The coach asks players to run from one corner to the other corner diagonally across. What is that distance, to the nearest tenths place.
Kimberly Reply
Jeannette has $5 and $10 bills in her wallet. The number of fives is three more than six times the number of tens. Let t represent the number of tens. Write an expression for the number of fives.
August Reply
What is the expressiin for seven less than four times the number of nickels
Leonardo Reply
How do i figure this problem out.
how do you translate this in Algebraic Expressions
linda Reply
why surface tension is zero at critical temperature
Shanjida
I think if critical temperature denote high temperature then a liquid stats boils that time the water stats to evaporate so some moles of h2o to up and due to high temp the bonding break they have low density so it can be a reason
s.
Need to simplify the expresin. 3/7 (x+y)-1/7 (x-1)=
Crystal Reply
. After 3 months on a diet, Lisa had lost 12% of her original weight. She lost 21 pounds. What was Lisa's original weight?
Chris Reply
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Source:  OpenStax, The art of the pfug. OpenStax CNX. Jun 05, 2013 Download for free at http://cnx.org/content/col10523/1.34
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