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Major trunks and ducts of the lymphatic system

This figure shows the lymphatic trunks and the duct system in the human body. Callouts to the left and right show the magnified views of the left and right jugular vein respectively.
The thoracic duct drains a much larger portion of the body than does the right lymphatic duct.

The overall drainage system of the body is asymmetrical (see [link] ). The right lymphatic duct    receives lymph from only the upper right side of the body. The lymph from the rest of the body enters the bloodstream through the thoracic duct    via all the remaining lymphatic trunks. In general, lymphatic vessels of the subcutaneous tissues of the skin, that is, the superficial lymphatics, follow the same routes as veins, whereas the deep lymphatic vessels of the viscera generally follow the paths of arteries.

The organization of immune function

The immune system is a collection of barriers, cells, and soluble proteins that interact and communicate with each other in extraordinarily complex ways. The modern model of immune function is organized into three phases based on the timing of their effects. The three temporal phases consist of the following:

  • Barrier defenses such as the skin and mucous membranes, which act instantaneously to prevent pathogenic invasion into the body tissues
  • The rapid but nonspecific innate immune response    , which consists of a variety of specialized cells and soluble factors
  • The slower but more specific and effective adaptive immune response    , which involves many cell types and soluble factors, but is primarily controlled by white blood cells (leukocytes) known as lymphocytes    , which help control immune responses

The cells of the blood, including all those involved in the immune response, arise in the bone marrow via various differentiation pathways from hematopoietic stem cells ( [link] ). In contrast with embryonic stem cells, hematopoietic stem cells are present throughout adulthood and allow for the continuous differentiation of blood cells to replace those lost to age or function. These cells can be divided into three classes based on function:

  • Phagocytic cells, which ingest pathogens to destroy them
  • Lymphocytes, which specifically coordinate the activities of adaptive immunity
  • Cells containing cytoplasmic granules, which help mediate immune responses against parasites and intracellular pathogens such as viruses

Hematopoietic system of the bone marrow

This flowchart shows the steps in which a multipotential hematopoietic stem cell differentiates into the different cell types in blood.
All the cells of the immune response as well as of the blood arise by differentiation from hematopoietic stem cells. Platelets are cell fragments involved in the clotting of blood.

Lymphocytes: b cells, t cells, plasma cells, and natural killer cells

As stated above, lymphocytes are the primary cells of adaptive immune responses ( [link] ). The two basic types of lymphocytes, B cells and T cells, are identical morphologically with a large central nucleus surrounded by a thin layer of cytoplasm. They are distinguished from each other by their surface protein markers as well as by the molecules they secrete. While B cells mature in red bone marrow and T cells mature in the thymus, they both initially develop from bone marrow. T cells migrate from bone marrow to the thymus gland where they further mature. B cells and T cells are found in many parts of the body, circulating in the bloodstream and lymph, and residing in secondary lymphoid organs, including the spleen and lymph nodes, which will be described later in this section. The human body contains approximately 10 12 lymphocytes.

Questions & Answers

What is anatomy !?
Arun Reply
the study of different parts of body to discover situation structure and economy
Aurelia
Anatomy is a study of structure of the body parts and it's consistents. Anatomy is a Greek word which means to cut up
Asma
Which book is perfect for anatomy ? among BD , Vishram , Gray's !?
Arun
iama Student of 1st year
Arun
Ashalata Anatomy text book
Johanna
The study of various body structures and their relationship with one another
Onwochie
Ross and Wilson's anatomy textbook
Onwochie
Anatomy is the study of human structure, functions and other relative organs in the system
Ayorinde
ross and willson book
Tifu
the study of structure unite of body
Faisal
thanks to all
Arun
Does anyone Read A.K dutta?
Arun
refer to the study of human body structure
SAID
which nerve orginates from pons
Kripa Reply
trigeminal nerve
madhuri
demand and supply rules
jamac Reply
compative demand and supply
jamac
compare demand and supply
jamac
what are simple epithelial tissues
Ushie Reply
is a type of tissue which covers the external and internal part of the body
Fatou
more information would be better understanding.
Tasha
what is platelets
Lilian Reply
platelet is also known as thrombocyte.thrombo means clot.it is a formed element of blood formed from fragment of megakaryocyte surrounded by plasma membrane in the redbone marow
Adeyemo
what is diabetes insipidus
namrata Reply
it is an infection due to less or no secretion of ADH characterized by excretion of dilute urine
Meshack
Infection? I don't think any form of diabetes, whether it's mellitus or insipidus, is caused by an infection.
Matias
ya
Akanyijuka
it is the disorder of salt & water metabolism
Emma
diabetes inspidus is a condition were the liver can't produce insulin to convert the excess sugar to glycogen.
mangs
sorry that is for diabetes mellitus
mangs
what is septal cartilage
Arthur Reply
I don't understand please
Esther Reply
hey
Austine
good evening boss
Austine
Evening
Esther
good evening
Melissa
evening
Vitus
hi
Rodgers
good morning
Aurelia
hello
Helsa
you guys are from ?
Aurelia
Philippines
Helsa
im from india
Aurelia
Hello
Amos
why
Sami
wat
Rodgers
what's that
Gift
what's the medulla?
alhussiney Reply
The medulla oblongata or simply medulla is a long stem-like structure which makes up the lower part of the brainstem. It is anterior and partially inferior to the cerebellum
Ludmila
define bone in simple terms
Mhoses Reply
bones are made up by collagen and calcium phosphate
Aurelia
yes
Confidence
Bones are the hard large calcareous connective tissue of which the adult skeleton of most vertebrates is chiefly composed
Olalekan
Bone is the substance that forms skeleton
Frances
good morning
Mrinal
Skelton muscles is any disorder of calcium
Mrinal
Bones protect the various organs of the body
Celina
Bone is a hard strong and durable type of connective tissue
Bkv
bone is a hard, calcareous connective tissue which gives structural support to the body and helpless in its locomotion!
Divya
It also is the main site for synthesis of the RBCs
Divya
thanks for your answers
Mhoses
A diagram of epithelial tissue
Emmanuel Reply
What does the urinary regulate blood pressure
Jennifer Reply
functions of melatonin
marion Reply
d. inversely proportional
John Reply
Airway resistance in the human lung is? a. Greatest in the generation of distal bronchioles in healthy people because these airways have the smallest radii b. Not increased during a forced expiration in a healthy subject c. Decreased when breathing through the mouth d. Inversely proportional
Maryam Reply

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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