Using tools from graph theory, we are able to link a certain class of Palm's cell assemblies, which we will call a
k -assembly, to the closure of a minimal
k -core. Using MATLAB, we are able to find a minimal
k -core and it's closure allowing us to find a
k -assembly in any given network of neurons.
k -cores
k -cores are a concept in graph theory that has been widely used and studied by many graph theorists for locating cohesive subsets in a given graph. A
k -core can be defined as:
Given graph
G , subgraph
X is a
k -core if every node in
X has at lease
k neighbors in
X . A
k -core can be described as minimal if no proper subset of the
k -core is also a
k -core.
Algorithms for finding a
k -assembly
The closure (the invariant set generated by iterating the e map) of a minimal
k -core is a
k -assembly
One type of cell assembly, we will call a
k -assembly, is the closure of a minimal
k -core. In order to find these
k -assemblies, we needed to develop a method for finding minimal
k -cores and their closures in any given network of neurons.
Finding minimal
k -cores:
bintprog is a built in MATLAB function that Þnds an optimal solution to binary integer programming problems of the following form:
$$\underset{x}{min}{f}^{T}x$$
$$Ax\le b$$
$$x\in {\{0,1\}}^{n}$$
bintprog arguments:
$f,A,b$
f : coefficients of the variables of the objective functions
$A,b$ : Using the threshold inequality we can find
A :
$${A}_{d}x\ge kx\u27f90\ge (kI-{A}_{d})x$$
bintprog minimizes
${f}^{T}x$ constrained to
$Ax\le b$ . Because x=0 satisfies the inequality we must add an additional constraint
There are, however, many other minimal
k -cores in this set of neurons such as: {3,4,5} and {2,5,6}. Our goal for the future is to find some method that enables
bintprog to find all of the minimal
k -cores in a given network allowing us to find all of the
k -assemblies in that network.
Closure example
We will use the same graph as the previous
bintprog example:
Create a subset,
x . We will use the minimal 2-core found by
bintprog :
Even though
${e}^{2}(x,k)\ne x$ , we can see that because the entire graph is excited, it will keep exciting itself, thus generating an invariant set giving us a
k -assembly:
In order to find more cell assemblies in any given network of neurons, we have come up with a few methods of finding other minimal
k -cores in a network of neurons:
Alter the arguments of
bintprog
We have altered with the coefficients of the objective function where we would increase the value for nodes already found in a previous minimal
k -core. This method has, however, proved to be exhaustive in that we must increase the value of the objective coefficients with all possible combinations of nodes of the previously found minimal
k -cores to ensure that all the minimal
k -cores of any given graph are located.
Translate other graph theoretical algorithms to fit minimal
k -cores
We hope to use algorithms in graph theory for finding other types of subgraphs, such as a maximal clique, and translate them to fit our problem of finding all of the minimal
k -cores of any given graph.
Use probability in random graphs
Using probability may allow us to figure out how many minimal
k -cores a given graph may support as well as where they might be, allowing us to constrain other exhaustive methods of finding minimal
k -cores.
Conclusion
This module has shown how to translate the problem of finding cell assemblies in a network of neurons into a binary integer programming problem. It has shown a clear connection between cell assemblies and graph theory and also how to find at least one cell assembly in any given network of neurons. Future work for this problem includes how to find more cell assemblies in a network of neurons.
Acknowledgements
I would like to give a big thanks to Dr. Steve Cox and Dr. Illya Hicks for guiding us through our project of finding cell assemblies. Also thanks to the REU students, Karina Aliaga, Shaunak Das, and Diane Taylor who I collaborated with on this project. Lastly I would like to thank NSF and the VIGRE program for funding me under the NSF VIGRE Grant DMS-0240058.
References
1. Hebb, Donald. (1949) The Organization of Behavior. (New York: John Wiley).
2. Palm, Gunther. (1981) Towards a Theory of Cell Assemblies. Biological Cybernetics 39, pp. 181-194.
Questions & Answers
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