# 8.4 Modeling cell assemblies  (Page 7/9)

 Page 7 / 9

## Network size and patterns

In the simulations there will be 50 E-cells and 50 I-cells. The Network will be "trained" to encode assemblies by running the weight producing algorithm on a set of patterns, each which represents a cell assembly (remember weights are only produced between the E-cells initially). There will be 8 patterns that contain 8 E-Cells in each. Each "event" or pattern will carry equal significance when the weighting algorithm runs. To help visualize the patterns look at the diagram below.

## Parameters for cells

Below are tables with parameter that are given exactly from A Lansner and E Fransen.

 Parameter E-Cell I-Cell ${V}_{leak}$ (mV) -50 -70 ${G}_{core}$ 0.04 0.0638 ${G}_{m}$ Soma $\left(\mu S\right)$ 0.0032 0.0016 ${C}_{m}$ Soma $\left(nF\right)$ 0.032 0.016 ${G}_{m}$ $\left(\mu S\right)$ Dentrites 0.0096 0.0096 ${C}_{m}$ Dentrites $\left(nF\right)$ 0.288 0.288 ${V}_{Na}$ 40 50 ${G}_{Na}$ $\left(\mu S\right)$ 1.0 1.0 ${V}_{K}$ -70 -90 ${G}_{K}$ $\left(\mu S\right)$ 0.5 1.0 ${V}_{Ca}$ 150 150 ${G}_{Ca}$ $\left(\mu S\right)$ 0 0 ${G}_{K\left(Ca\right)}$ $\left(\mu S\right)$ 0.0017 0.01 ${\rho }_{AP}$ (mV ${}^{-1}$ ms ${}^{-1}$ ) 4 0.013 ${\delta }_{AP}$ ms ${}^{-1}$ .075 .02
 m h n q p A (mV ${}^{-1}$ ms ${}^{-1}$ ) 0.2 0.08 0.02 0.08 0.7 (ms ${}^{-1}$ ) $\alpha$ B (mV) -40 -40 -15 -25 C (mV) 1 1 0.8 1 17 A (mV ${}^{-1}$ ms ${}^{-1}$ ) 0.06 0.4 0.04 0.005 0.1 (ms ${}^{-1}$ ) $\beta$ B (mV) -49 -36 -40 -20 C (mV) 20 2 0.4 20 17
 m h n q A (mV ${}^{-1}$ ms ${}^{-1}$ ) 0.2 0.08 0.02 0.08 $\alpha$ B (mV) -30 -30 -21 -15 C (mV) 1 0.2 0.2 1 A (mV ${}^{-1}$ ms ${}^{-1}$ ) 0.06 0.4 0.02 0.005 $\beta$ B (mV) -38 -26 -18 -10 C (mV) 20 0.2 0.2 20
 ${V}_{syn}$ Excitatory 0 $mV$ ${V}_{syn}$ Inhibitory -85 $mV$ $s$ variable ${G}_{syn}$ E to E (AMPA) ${w}_{ij}$ x ${w}_{E2E}$ ${G}_{syn}$ E to I (AMPA) ${w}_{ij}$ x ${w}_{E2I}$ ${G}_{syn}$ I to E ${g}_{I2E}$ ${G}_{NMDA}$ E to E ${G}_{syn}$ x ${w}_{NMDA}scalar$ ${\rho }_{NMDA}$ E to E ${G}_{syn}$ x ${\rho }_{NMDA}scalar$ ${\delta }_{NMDA}$ $m{s}^{-1}$ .02

## Remaining parameters

There are a few parameters that remain to be given values. A Lanser and Fransen do not give exact values for these unknown parameters, but instead a desired range for EPSP's (Excitatory Post Synaptic Potentials) that the parameters help determine. By experimenting with a single neuron we can find the ideal range for these unknown parameters. Hence, we can then scale the resulting Weights from the algorithm so they are mapped to the ideal range. We need an overall weighting scale constant for connections from E to E cells (AMPA), ${w}_{E2E}$ . A weighting scale constant for E to I cells, ${w}_{E2I}$ Also, a scale general conductance constant for all I to E connections, ${g}_{I2E}$ . The NMDA connections will be proportional to the AMPA weight but scaled by a constant ${w}_{NMDA}scalar$ . The influx parameter ${\rho }_{NMDA}$ for the $\left[C{a}_{NMDA}\right]$ pool is also proportional to the AMPA weight. Lastly, the binary variable $s$ needs to be given a time duration to stay active for. This time duration may be chosen different for each type of connection class as well (meaning E to E, E to I, and I to E).

Most of these unfixed variables relate to the strength of connections between cells and the EPSPs or IPSPs they create. The reason they won't be fixed for all different size simulations is that the values should vary according to size of the networks and assemblies. For instance, if we model on large networks that have large assemblies we would desire that a cell would require synaptic input from more cells in order to fire, than when the network is small. By picking these numbers accordingly we will be able to roughly determine how many cells of an assembly need to be firing in order to fully activate the assembly.

where we get a research paper on Nano chemistry....?
nanopartical of organic/inorganic / physical chemistry , pdf / thesis / review
Ali
what are the products of Nano chemistry?
There are lots of products of nano chemistry... Like nano coatings.....carbon fiber.. And lots of others..
learn
Even nanotechnology is pretty much all about chemistry... Its the chemistry on quantum or atomic level
learn
da
no nanotechnology is also a part of physics and maths it requires angle formulas and some pressure regarding concepts
Bhagvanji
hey
Giriraj
Preparation and Applications of Nanomaterial for Drug Delivery
revolt
da
Application of nanotechnology in medicine
what is variations in raman spectra for nanomaterials
I only see partial conversation and what's the question here!
what about nanotechnology for water purification
please someone correct me if I'm wrong but I think one can use nanoparticles, specially silver nanoparticles for water treatment.
Damian
yes that's correct
Professor
I think
Professor
Nasa has use it in the 60's, copper as water purification in the moon travel.
Alexandre
nanocopper obvius
Alexandre
what is the stm
is there industrial application of fullrenes. What is the method to prepare fullrene on large scale.?
Rafiq
industrial application...? mmm I think on the medical side as drug carrier, but you should go deeper on your research, I may be wrong
Damian
How we are making nano material?
what is a peer
What is meant by 'nano scale'?
What is STMs full form?
LITNING
scanning tunneling microscope
Sahil
how nano science is used for hydrophobicity
Santosh
Do u think that Graphene and Fullrene fiber can be used to make Air Plane body structure the lightest and strongest. Rafiq
Rafiq
what is differents between GO and RGO?
Mahi
what is simplest way to understand the applications of nano robots used to detect the cancer affected cell of human body.? How this robot is carried to required site of body cell.? what will be the carrier material and how can be detected that correct delivery of drug is done Rafiq
Rafiq
if virus is killing to make ARTIFICIAL DNA OF GRAPHENE FOR KILLED THE VIRUS .THIS IS OUR ASSUMPTION
Anam
analytical skills graphene is prepared to kill any type viruses .
Anam
Any one who tell me about Preparation and application of Nanomaterial for drug Delivery
Hafiz
what is Nano technology ?
write examples of Nano molecule?
Bob
The nanotechnology is as new science, to scale nanometric
brayan
nanotechnology is the study, desing, synthesis, manipulation and application of materials and functional systems through control of matter at nanoscale
Damian
Is there any normative that regulates the use of silver nanoparticles?
what king of growth are you checking .?
Renato
What fields keep nano created devices from performing or assimulating ? Magnetic fields ? Are do they assimilate ?
why we need to study biomolecules, molecular biology in nanotechnology?
?
Kyle
yes I'm doing my masters in nanotechnology, we are being studying all these domains as well..
why?
what school?
Kyle
biomolecules are e building blocks of every organics and inorganic materials.
Joe
how did you get the value of 2000N.What calculations are needed to arrive at it
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