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Synthesis of vitamin d

This illustration resembles a flow chart. It begins with the sun shining on a silhouette of a man. One arrow leads from the sun to the man’s skin, stating that Vitamin D is manufactured in the skin after the absorption of sunlight. Another arrow points into the man’s mouth and states that Vitamin D is ingested through food and supplements, absorbed by the intestines, and carried to the liver via the bloodstream. A call out of the liver states that, in the liver, Vitamin D turns into 25 (OH) D, also known as calcidiol, the primary form of circulating Vitamin D. Another callout of the right kidney states that, in the kidneys, Vitamin D is transformed into 1 25 OH (D2). This is also known as calcitriol, a biologically active form of Vitamin D. The synthesis of Vitamin D facilitates calcium absorption from the small intestine, calcium re-absorption from the kidneys, and the rebuilding of bone tissue.
Sunlight is one source of vitamin D.

Other nutrients

Vitamin K also supports bone mineralization and may have a synergistic role with vitamin D in the regulation of bone growth. Green leafy vegetables are a good source of vitamin K.

The minerals magnesium and fluoride may also play a role in supporting bone health. While magnesium is only found in trace amounts in the human body, more than 60 percent of it is in the skeleton, suggesting it plays a role in the structure of bone. Fluoride can displace the hydroxyl group in bone’s hydroxyapatite crystals and form fluorapatite. Similar to its effect on dental enamel, fluorapatite helps stabilize and strengthen bone mineral. Fluoride can also enter spaces within hydroxyapatite crystals, thus increasing their density.

Omega-3 fatty acids have long been known to reduce inflammation in various parts of the body. Inflammation can interfere with the function of osteoblasts, so consuming omega-3 fatty acids, in the diet or in supplements, may also help enhance production of new osseous tissue. [link] summarizes the role of nutrients in bone health.

Nutrients and Bone Health
Nutrient Role in bone health
Calcium Needed to make calcium phosphate and calcium carbonate, which form the hydroxyapatite crystals that give bone its hardness
Vitamin D Needed for calcium absorption
Vitamin K Supports bone mineralization; may have synergistic effect with vitamin D
Magnesium Structural component of bone
Fluoride Structural component of bone
Omega-3 fatty acids Reduces inflammation that may interfere with osteoblast function

Hormones and bone tissue

The endocrine system produces and secretes hormones, many of which interact with the skeletal system. These hormones are involved in controlling bone growth, maintaining bone once it is formed, and remodeling it.

Hormones that influence osteoblasts and/or maintain the matrix

Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth in several ways. It triggers chondrocyte proliferation in epiphyseal plates, resulting in the increasing length of long bones. GH also increases calcium retention, which enhances mineralization, and stimulates osteoblastic activity, which improves bone density.

GH is not alone in stimulating bone growth and maintaining osseous tissue. Thyroxine, a hormone secreted by the thyroid gland promotes osteoblastic activity and the synthesis of bone matrix. During puberty, the sex hormones (estrogen in girls, testosterone in boys) also come into play. They too promote osteoblastic activity and production of bone matrix, and in addition, are responsible for the growth spurt that often occurs during adolescence. They also promote the conversion of the epiphyseal plate to the epiphyseal line (i.e., cartilage to its bony remnant), thus bringing an end to the longitudinal growth of bones. Additionally, calcitriol, the active form of vitamin D, is produced by the kidneys and stimulates the absorption of calcium and phosphate from the digestive tract.

Questions & Answers

What is the difference between regional anatomy and systematic anatomy?
Andrew Reply
Regional anatomy is the study of the interrelationships of all of the structures in a specific body region, such as the abdomen. ... In contrast, systemic anatomy is the study of the structures that make up a discrete body system—that is, a group of structures that work together to perform a unique
Tammy
so meaning of dissect
Mary Reply
it is the dismembering or the cutting of living organism to study the anatomical structure of it body
Kwasi
what are lymph nodes
Memory Reply
what is the best book that shows unit 1 about cell unit 2 about tissue unit 3 about embroyology
Abraham Reply
2
Hellen
to understand structure of body able to understand function of system. to understand how to build human body and function
Dereje Reply
hi
Neela
to determine body structures
Petra Reply
to know the use of each and every part of our body
Petra
to understand how our body structures work to support our lives
Petra
Is this a question?
Tammy
So what was the question?
Thamie
All the body work together to make the whole organism life possible
Kwasi
what is the importance of conversation
Hellen
To be able to identify the parts of the body and their functions
Hodasi
ok
Hodasi
Ideas are shared during conversation also informations are given
Hodasi
it reduces cost
Kwasi
what is carbon dioxide respiratory system why?
Prachi Reply
Carbon dioxide (CO2) is involved with the chemical process of cellular respiration. It is produced as a cellular waste product during the decomposition reactions and serves an important role in maintaining the appropriate acid-base balance in the body.
Tammy
thank you
Prachi
You're welcome!
Tammy
i have not under stood human heart
Simbwa Reply
means?
Dilshan
why a man became wild at the time of sexual intercourse. reason?
Soul
what is anatomy
philemon Reply
what is anatomy in terms of medicine
philemon
it is the study of human and animal form by observing and examined them and sometimes dissecting them and view the tiny thing by the use of microscope
Kwasi
anatomy is simply the scientific study of the body's structures
Petra
study of human body and animal
Crystal
why a man becomes wild at the time of sexual intercourse
Soul
Anatomy is the study of structure of the human body.
Tammy
Physiology is the study of the functions of the human body
Tammy
what is the difference between regional anatomy and systematic anatomy?
Andrew
Describe early studies into the working of human body.
Tonny Reply
please guys help me to answer this question; Define the two divisions of the skeleton ?
Jonathan Reply
two example of appendicular skeleton
Jonathan
upper limb ;eg humerus n lower limb;eg tibia
BRIAN
write notes on the level of organizations of the body .citing examples for each level
Kaddijatou Reply
Jonathan Nyakpaab
Jonathan
what is pathology
Ericka Reply
1 What is Nasogastric Tube 2 what is the difference between Nasogastric Aspiration and Nasogastric Feeling
ONOJA Reply
You measure a patient’s blood pressure at 130/85. Calculate the patient’s pulse pressure and mean arterial pressure. Determine whether each pressure is low, normal, or high.
ONOJA
normal blood pressure 120/80
Mohd
what are nocciceptors
Soul
hfjfjcjjjghkbv
Mohd
1 Its a flexible tube of plastic that pass through the nose, down to the eausophagus, and into the stomach, used to add or remove substances in the stomach.
Andile
2 Nasogastric aspiration is process of draining stomach contents via a tube and Nasogastric feeding is a process of giving food liquid through nasogastric tube
Andile
andile sir what is meant by clonoscopy
Soul
colonoscpopy is an exam use to detect abnormalities in the small intestine or the colon
Kwasi
What is the skin
Astony Reply

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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