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  • Explain the concept of radiotherapy and list typical doses for cancer therapy.

Therapeutic applications of ionizing radiation, called radiation therapy or radiotherapy    , have existed since the discovery of x-rays and nuclear radioactivity. Today, radiotherapy is used almost exclusively for cancer therapy, where it saves thousands of lives and improves the quality of life and longevity of many it cannot save. Radiotherapy may be used alone or in combination with surgery and chemotherapy (drug treatment) depending on the type of cancer and the response of the patient. A careful examination of all available data has established that radiotherapy’s beneficial effects far outweigh its long-term risks.

Medical application

The earliest uses of ionizing radiation on humans were mostly harmful, with many at the level of snake oil as seen in [link] . Radium-doped cosmetics that glowed in the dark were used around the time of World War I. As recently as the 1950s, radon mine tours were promoted as healthful and rejuvenating—those who toured were exposed but gained no benefits. Radium salts were sold as health elixirs for many years. The gruesome death of a wealthy industrialist, who became psychologically addicted to the brew, alerted the unsuspecting to the dangers of radium salt elixirs. Most abuses finally ended after the legislation in the 1950s.

The image shows an old advertisement of radium material branded as UNDARK with the tagline “Shines in the Dark.”
The properties of radiation were once touted for far more than its modern use in cancer therapy. Until 1932, radium was advertised for a variety of uses, often with tragic results. (credit: Struthious Bandersnatch.)

Radiotherapy is effective against cancer because cancer cells reproduce rapidly and, consequently, are more sensitive to radiation. The central problem in radiotherapy is to make the dose for cancer cells as high as possible while limiting the dose for normal cells. The ratio of abnormal cells killed to normal cells killed is called the therapeutic ratio    , and all radiotherapy techniques are designed to enhance this ratio. Radiation can be concentrated in cancerous tissue by a number of techniques. One of the most prevalent techniques for well-defined tumors is a geometric technique shown in [link] . A narrow beam of radiation is passed through the patient from a variety of directions with a common crossing point in the tumor. This concentrates the dose in the tumor while spreading it out over a large volume of normal tissue. The external radiation can be x-rays, 60 Co  γ rays, or ionizing-particle beams produced by accelerators. Accelerator-produced beams of neutrons, π-mesons , and heavy ions such as nitrogen nuclei have been employed, and these can be quite effective. These particles have larger QFs or RBEs and sometimes can be better localized, producing a greater therapeutic ratio. But accelerator radiotherapy is much more expensive and less frequently employed than other forms.

The image shows a man lying on a flat surface. A gamma ray machine is rotated around the man.
The 60 Co source of γ -radiation is rotated around the patient so that the common crossing point is in the tumor, concentrating the dose there. This geometric technique works for well-defined tumors.

Questions & Answers

What is specific heat capacity?
hamidat Reply
Specific heat capacity is the amount of heat required to raise the temperature of one (Kg) of a substance through one Kelvin
Paluutar
formula for measuring Joules
Rowshan Reply
I don't understand, do you mean the S.I unit of work and energy?
hamidat
what are the effects of electric current
ADAMS Reply
What limits the Magnification of an optical instrument?
Naeem Reply
Lithography is 2 micron
Venkateshwarlu
what is expression for energy possessed by water ripple
Prabesh Reply
what is hydrolic press
Mark Reply
An hydraulic press is a type of machine that is operated by different pressure of water on pistons.
hamidat
what is dimensional unite of mah
Patrock Reply
i want jamb related question on this asap🙏
sharon Reply
What is Boyles law
Pascal Reply
it can simple defined as constant temperature
Muhammad
Boyles law states that the volume of a fixed amount of a gas is inversely proportional to the pressure acting on in provided that the temperature is constant.that is V=k(1/p) or V=k/p
FADILAT
what is motion
Mua Reply
getting notifications for a dictionary word, smh
Anderson
what is escape velocity
Shuaibu Reply
the minimum thrust that an object must have in oder yo escape the gravitational pull
Joshua
what is a dimer
Mua
what is a atom
ADAMS
how to calculate tension
Deena Reply
what are the laws of motion
Mua
what is force
Ugwu Reply
Force is any quantity or a change that produces motion on an object body.
albert
A force is a push or a pull that has the tendency of changing a body's uniform state of rest or uniform state of motion in a straight line.
nicholas
plsoo give me the gravitational motion formulas
Okoye
f=Gm/d²
FADILAT
What is the meaning of emf
Chinedu Reply
electro magnetic force
shafiu
Electromotive force (emf) is a measurement of the energy that causes current to flow through a circuit.
Darssini
tritium (gas, netrogen, cloud, lamp)
firdaus Reply
Continue - > tritium (gas, netrogen, cloud, lamp span, lamp light, cool)
firdaus
Practice Key Terms 2

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Source:  OpenStax, College physics. OpenStax CNX. Jul 27, 2015 Download for free at http://legacy.cnx.org/content/col11406/1.9
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