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The breakdown of fatty acids, called fatty acid oxidation    or beta (β)-oxidation    , begins in the cytoplasm, where fatty acids are converted into fatty acyl CoA molecules. This fatty acyl CoA combines with carnitine to create a fatty acyl carnitine molecule, which helps to transport the fatty acid across the mitochondrial membrane. Once inside the mitochondrial matrix, the fatty acyl carnitine molecule is converted back into fatty acyl CoA and then into acetyl CoA ( [link] ). The newly formed acetyl CoA enters the Krebs cycle and is used to produce ATP in the same way as acetyl CoA derived from pyruvate.

Breakdown of fatty acids

This figure shows the reactions that break down fatty acids. The top panel shows the conversion of fatty acids into carnitine. The bottom panel shows the conversion of carnitine into acetyl-CoA.
During fatty acid oxidation, triglycerides can be broken down into acetyl CoA molecules and used for energy when glucose levels are low.

Ketogenesis

If excessive acetyl CoA is created from the oxidation of fatty acids and the Krebs cycle is overloaded and cannot handle it, the acetyl CoA is diverted to create ketone bodies    . These ketone bodies can serve as a fuel source if glucose levels are too low in the body. Ketones serve as fuel in times of prolonged starvation or when patients suffer from uncontrolled diabetes and cannot utilize most of the circulating glucose. In both cases, fat stores are liberated to generate energy through the Krebs cycle and will generate ketone bodies when too much acetyl CoA accumulates.

In this ketone synthesis reaction, excess acetyl CoA is converted into hydroxymethylglutaryl CoA (HMG CoA)    . HMG CoA is a precursor of cholesterol and is an intermediate that is subsequently converted into β-hydroxybutyrate, the primary ketone body in the blood ( [link] ).

Ketogenesis

This pathway shows the production of beta-hydroxybutyrate from acetyl-CoA.
Excess acetyl CoA is diverted from the Krebs cycle to the ketogenesis pathway. This reaction occurs in the mitochondria of liver cells. The result is the production of β-hydroxybutyrate, the primary ketone body found in the blood.

Ketone body oxidation

Organs that have classically been thought to be dependent solely on glucose, such as the brain, can actually use ketones as an alternative energy source. This keeps the brain functioning when glucose is limited. When ketones are produced faster than they can be used, they can be broken down into CO 2 and acetone. The acetone is removed by exhalation. One symptom of ketogenesis is that the patient’s breath smells sweet like alcohol. This effect provides one way of telling if a diabetic is properly controlling the disease. The carbon dioxide produced can acidify the blood, leading to diabetic ketoacidosis, a dangerous condition in diabetics.

Ketones oxidize to produce energy for the brain. beta (β)-hydroxybutyrate    is oxidized to acetoacetate and NADH is released. An HS-CoA molecule is added to acetoacetate, forming acetoacetyl CoA. The carbon within the acetoacetyl CoA that is not bonded to the CoA then detaches, splitting the molecule in two. This carbon then attaches to another free HS-CoA, resulting in two acetyl CoA molecules. These two acetyl CoA molecules are then processed through the Krebs cycle to generate energy ( [link] ).

Questions & Answers

Description of menestraul cycle
Amos Reply
what is the anatomy
FAKE Reply
Anatomy is study of structure of organs.
Sneha
thanks
FAKE
The scientific study of the structure of human or animal bodies.
FAKE
I was confused as to which one would be right and I asked
FAKE
My answer and you answer both are right.
Sneha
i want to improve my study i like this app i interest physiology and anatomy
Su Reply
I also like this app am really interested in learning anatomy and physiology.
Johny
I have this book with my anatomy class it's awesome! also if look at crashcourse anatomy on you tube!
AMY
what the name
isaiah
umesh. rede
Rede
what is heart and long type answer
Lalita Reply
its a organ in the body
ay
describe about hear chambers.. valves.. arteries.. veins.. circulation.. inferior/superior venacava, aorta., tricuspid valve, mitral valve. pulmonary artery/vein, how oxigenation occur,systolic presure diastolic pressure.. stroke volume,cardiac output, ets.. heart located in which place, describe it
Sanjith
if you describe what I cited up, thogh you can write a long type answer about heart
Sanjith
autonomic functions took over
Vanarith Reply
What did they take over?
Eric
what is the average volume of blood in men and why does it varrie from women?
Esther Reply
what is the average volume of blood in men
Esther
5to6liter
Sarita
5to6liter dt
Sarita
umesh. rede
Rede
what is the definition of anatomy
Noriah Reply
Search google
killer
^of
chieng
The study of the structure or internal workings of something. "Machiavelli's anatomy 
Eric
post. communi. artey... this may be true 70% hope correct
vikash Reply
what is the strongest muscle in the human body?
Robiam Reply
masseter muscles
Om
yes masseter..... jaw muscle is the strongest muscle..
Sarita
Kidneys have direct effect on which
The function the loop
function of the loop?
Eric
the function of the loop of henle is to increase surface area for reasorbtion.
Conan
what is an atom and it's functions
Jany
An atom is the basic building block of matter.
Eric
which is the largest digestive gland in our body
Shubu
stomach
Barbara
What is the smallest bone in the body of the human being?
Kelvin
pisiform
Chulit
how many found in the head
obakunmi
4
ayesha
I think stapes is the smallest bone in human body
Sanjith
22
Sanjith
yes stapes is the smallest bone of our body
Sarita
the smallest bone is stapes in the ear
Isaac
smallest bone in human body is stapes or stirrup present in the middle ear ..
Om
stapes yes
Robiam
blood work and purification and it leads to cardiac systen
vikash
explain function of kidney
Noel Reply
filtration
Naqash
Secretagogue hormones
Sa
Organising water
Sa
hi
Jany
they help in the reproduction of sperms
Jany
Their main job is to cleanse the blood of toxins and transform the waste into urine. The kidney have several functions though. I think it is important to know them, but not in depth. But to truly understand the kindney's over all importance.
Eric
I meant to say the kidneys have.
Eric
how kidney help in reprdution of sperms?
Amir
the basic and functinal unit of kidney is Nephron
Sanjith
what us the name of the longest bone in the body
Ohuche Reply
femur
Zaini
femur
AKHILA
anatomical planes of the body
Opio Reply
sagittal plane, transverse plane and coronal plane
Ogechi
the only moveable bone in head
Sewar Reply
the only movable bone in head
Sewar
stapes. in the ear. but one could argue, all three ear bones move. malleus, Incas, and stapes.
Conan
mandible
Ankita
The mandible is.
Eric
The only unattached bone in the body is the hyod bone in the neck.
Eric
The mandible. It's the part that enables us to talk.
chieng
Mandible present in the head
Shubu
how can u protect ur self from corona
Nity Reply
how can u know that u have corona
Nity
with a test
Danielle
can protect by social distancing, following hand hygiene and standard precautions
Danielle
tq very much
sudhakar
as per the CDC incubation period 2 to 14 days. typical symptoms. typical symptoms, fever, cough, malagia, fatigue, and shortness of breath. alcohol based hand sanitizers. 60 to 85% strength, physical barriers, PPE. a face mask with three layers. Keep a physical distance of 6 feet or more.
Conan
a nasal swab test, or a blood test to confirm SARs-cov-19.
Conan

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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