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In some groups of organisms with sex chromosomes, the gender with the non-homologous sex chromosomes is the female rather than the male. This is the case for all birds. In this case, sex-linked traits will be more likely to appear in the female, in which they are hemizygous.

Human sex-linked disorders

Sex-linkage studies in Morgan’s laboratory provided the fundamentals for understanding X-linked recessive disorders in humans, which include red-green color blindness, and Types A and B hemophilia. Because human males need to inherit only one recessive mutant X allele to be affected, X-linked disorders are disproportionately observed in males. Females must inherit recessive X-linked alleles from both of their parents in order to express the trait. When they inherit one recessive X-linked mutant allele and one dominant X-linked wild-type allele, they are carriers of the trait and are typically unaffected. Carrier females can manifest mild forms of the trait due to the inactivation of the dominant allele located on one of the X chromosomes. However, female carriers can contribute the trait to their sons, resulting in the son exhibiting the trait, or they can contribute the recessive allele to their daughters, resulting in the daughters being carriers of the trait ( [link] ). Although some Y-linked recessive disorders exist, typically they are associated with infertility in males and are therefore not transmitted to subsequent generations.

A diagram shows an unaffected father with a dominant allele and an unaffected carrier mother with an x-linked recessive allele. Four figures of offspring are shown representing the various resulting genetic combinations: unaffected son, unaffected daughter, affected son, and unaffected carrier daughter.
The son of a woman who is a carrier of a recessive X-linked disorder will have a 50 percent chance of being affected. A daughter will not be affected, but she will have a 50 percent chance of being a carrier like her mother.

Watch this video to learn more about sex-linked traits.

Lethality

A large proportion of genes in an individual’s genome are essential for survival. Occasionally, a nonfunctional allele for an essential gene can arise by mutation and be transmitted in a population as long as individuals with this allele also have a wild-type, functional copy. The wild-type allele functions at a capacity sufficient to sustain life and is therefore considered to be dominant over the nonfunctional allele. However, consider two heterozygous parents that have a genotype of wild-type/nonfunctional mutant for a hypothetical essential gene. In one quarter of their offspring, we would expect to observe individuals that are homozygous recessive for the nonfunctional allele. Because the gene is essential, these individuals might fail to develop past fertilization, die in utero , or die later in life, depending on what life stage requires this gene. An inheritance pattern in which an allele is only lethal in the homozygous form and in which the heterozygote may be normal or have some altered non-lethal phenotype is referred to as recessive lethal    .

For crosses between heterozygous individuals with a recessive lethal allele that causes death before birth when homozygous, only wild-type homozygotes and heterozygotes would be observed. The genotypic ratio would therefore be 2:1. In other instances, the recessive lethal allele might also exhibit a dominant (but not lethal) phenotype in the heterozygote. For instance, the recessive lethal Curly allele in Drosophila affects wing shape in the heterozygote form but is lethal in the homozygote.

Questions & Answers

what is ecology
Adeyemo Reply
what is zoology
Adeyemo
zoology branch of biology that study animals
Moses
A plant is a living thing that grows in the earth and has a stem, leaves, and roots
Bello Reply
what is a plant
dalitso Reply
A plant is a living thing that grows in the earth and has a stem, leaves, and roots
Bello
a plant is an is a living thing that is classified under autothrops because it makes its own food through the process of photosynthesis .
Joanne
what is plant
Odion Reply
Plants are autotrophic
Baramox
Then animal are heterotrophic
Iyiola
what are organisms
Godfred Reply
Living structures
Aryavarta
the diagram below show how the blood of a human embryo flows close to the mothers blood in the placenta . which substances are represent at x in higher concentrations than at y
Joyce Reply
what is ecology
Odion Reply
what is cell
Odion
what is cell
Odion
Is the basic unit of life
Agatha
What is a cell
Awal Reply
What are tissues
Awal
A cell is the smallest unit of living organisms.
hamidat
Tissues are group of similar cells performing a particular function.
hamidat
how to pronounce the word cyanobacteria
siva Reply
Cyano then bacteria. look that "cyano" is just like "ciyano".
hamidat
explain the term transpiration pull
Tank Reply
water is mainly " pulled" through the plant and that the driving force for this process is transpiration from the leaves .This is also referred to as the cohesion- tension -transpiration pull model transport.
Vanessa
explain TRANSIOCATION and GUTATION
Tank
what Is corona
INGIEBE Reply
My brother go and ask GOOGLE😷😷😷
hamidat
Google it for the right answer. Corona is a virus which causes Novel Covid-19 disease that has been declared by WHO as a global or world pandemic.
Katlholo
Why is it called Covid-19?
Katlholo
jjwhat is. condinative system
Odion
joy
Odion
condinative system is the system that harmonize all the. different. part. of. the. body and make. them function as a. specific unit
Odion
Describe the process of protein sythesis?
Kizito Reply
Ribosomes are responsible for protein synthesis in animals.
hamidat
What is a ploidy level
Francis Reply
Ploidy refers to the number of chromosomes. We have 23 pairs of chromosomes in somatic cells. Sex cells are haploid thus 23 chromosomes vs. 46 Chromosomes.
Eric
Evolution is evolvement according to one's environment. Let's use humidity as an example. A person from a very cold environment would not be used to hot humid weather. But over time their body would slowly, slowly adapt.
Eric
Give me (3) types of biodiversity
Jay
Hi guys 🇧🇪
Namutebi
hello boy
Tedi
hi
INGIEBE
yes
amani
what do you guys understand about evolution?
Kiana Reply
it's a process or analayzing some program
Fahamia
but am not sure if some know plz let share
Fahamia
is a study of
Sarah
unfolding or unrolling hence the process of development of growth
Sarah
is the periodic change of the structural features of an organism
Rahim
I think
Rahim
process of developing
Nikita
hi guiz
Mohammed
hello guys
Safuna
hi
Kaniki
Evolution ~ Is the gradual change of development over time in which a new species are formed
amani
Evolution is the sum total of adaptive changes that has existed before.
hamidat
odionjimoh
Odion
hi
Odion
why are diagrams not available
Evans Reply

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Source:  OpenStax, Biology. OpenStax CNX. Feb 29, 2016 Download for free at http://cnx.org/content/col11448/1.10
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