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The indirect mechanism of GH action is mediated by insulin-like growth factors (IGFs) or somatomedins, which are a family of growth-promoting proteins produced by the liver, which stimulates tissue growth. IGFs stimulate the uptake of amino acids from the blood, allowing the formation of new proteins, particularly in skeletal muscle cells, cartilage cells, and other target cells, as shown in [link] . This is especially important after a meal, when glucose and amino acid concentration levels are high in the blood. GH levels are regulated by two hormones produced by the hypothalamus. GH release is stimulated by growth hormone-releasing hormone (GHRH)    and is inhibited by growth hormone-inhibiting hormone (GHIH)    , also called somatostatin.

Growth hormone, or GH released from the pituitary gland stimulates bone and muscle growth. It also stimulates fat breakdown by adipocytes and glucagon breakdown by the liver. The liver releases IGFs, which cause target cells to take up amino acids, promoting protein synthesis. GH-releasing hormone stimulates the release of GH, and GH-inhibiting hormone, inhibits the release of GH.
Growth hormone directly accelerates the rate of protein synthesis in skeletal muscle and bones. Insulin-like growth factor 1 (IGF-1) is activated by growth hormone and also allows formation of new proteins in muscle cells and bone. (credit: modification of work by Mikael Häggström)

A balanced production of growth hormone is critical for proper development. Underproduction of GH in adults does not appear to cause any abnormalities, but in children it can result in pituitary dwarfism    , in which growth is reduced. Pituitary dwarfism is characterized by symmetric body formation. In some cases, individuals are under 30 inches in height. Oversecretion of growth hormone can lead to gigantism    in children, causing excessive growth. In some documented cases, individuals can reach heights of over eight feet. In adults, excessive GH can lead to acromegaly    , a condition in which there is enlargement of bones in the face, hands, and feet that are still capable of growth.

Hormonal regulation of stress

When a threat or danger is perceived, the body responds by releasing hormones that will ready it for the “fight-or-flight” response. The effects of this response are familiar to anyone who has been in a stressful situation: increased heart rate, dry mouth, and hair standing up.

Evolution connection

Fight-or-flight response

Interactions of the endocrine hormones have evolved to ensure the body’s internal environment remains stable. Stressors are stimuli that disrupt homeostasis. The sympathetic division of the vertebrate autonomic nervous system has evolved the fight-or-flight response to counter stress-induced disruptions of homeostasis. In the initial alarm phase, the sympathetic nervous system stimulates an increase in energy levels through increased blood glucose levels. This prepares the body for physical activity that may be required to respond to stress: to either fight for survival or to flee from danger.

However, some stresses, such as illness or injury, can last for a long time. Glycogen reserves, which provide energy in the short-term response to stress, are exhausted after several hours and cannot meet long-term energy needs. If glycogen reserves were the only energy source available, neural functioning could not be maintained once the reserves became depleted due to the nervous system’s high requirement for glucose. In this situation, the body has evolved a response to counter long-term stress through the actions of the glucocorticoids, which ensure that long-term energy requirements can be met. The glucocorticoids mobilize lipid and protein reserves, stimulate gluconeogenesis, conserve glucose for use by neural tissue, and stimulate the conservation of salts and water. The mechanisms to maintain homeostasis that are described here are those observed in the human body. However, the fight-or-flight response exists in some form in all vertebrates.

Questions & Answers

complete the table below based on the levels of biological organization
Lovely Reply
Give me Examples of living thing which have 2 or more flagella?
Mahesh Reply
insect and plants
qax
bacteria and chlamydompnas
Berhanu
reproduction it's full meaning
Gift Reply
full meaning of ATP
Gifty
A life process in which living things increase their population through sexual or non sexual intercouse
Danisha
please explaination
Daniel
Gifty ATP means Adenosine tri phosphate
Mahesh
the process by which organisms produce their own kind.
Berhanu
reproduction is the process where living organisms producess their offspring
jerry Reply
what is reproduction
Nmesoma Reply
why some kinds of students are failed
Ahmadi Reply
lack of concentration
Faith
lack of guidance and counseling
ali
what's the divination of openstax
John
don't mind about reading
aine
lack of focus
Afolayan
What is the meaning of optic
Kisaky Reply
Giving a specific section of the alimentary canal,describe 3 ways in which physical digestion occurs.
Kisaky
mouth when chewing
ephraim
what is population
Ivy Reply
total number of people living in an area
FILDA
a number of people lives in one catigorize area or named area
Oburak
what is a cell
Chiko Reply
basic and functional unit of life
Edwin
cell is tissues that makes up functional life in human or un animal.
Oburak
is the smallest basic unit of life.
Kisaky
Is the smallest baic unit. o
Kisaky
why cell is very important to human body
Ahmadi
what is diffusion
Henry
diffusion is a process of mix of particles from higher concentration to the lower one,to make the body functional normal
Adam
what is effusion
Mahesh
what is soil
FILDA Reply
Is the finely divided material covering the earth crust.
Kisaky
is the upper moist of layer of the earth surface
Ahmadi
what is reducing sugar
Erica Reply
in genetics which disease is also termed as the queen disease
Phinihas Reply
what are the types of cell
Teye Reply
prokaryote ,eukaryote, akaryotes
bonney
what is akaryotes ?
Chriscia
multicellular and unicellular
Edwin
akaryotes are organisms that function as eukaryotes and prokaryotes
Edwin
akaryotes are cell with no nucleus
Edwin
biology is the study of living organisms
bonney Reply
what's the divination of open stax?
John
biology is designed for multi- semester biology course for science Major
John
what are the important of cells in the body
Nharnhar Reply

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Source:  OpenStax, Biology. OpenStax CNX. Feb 29, 2016 Download for free at http://cnx.org/content/col11448/1.10
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