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Although the correlation is not 100 percent, CD4-bearing T cells are associated with helper functions and CD8-bearing T cells are associated with cytotoxicity. These functional distinctions based on CD4 and CD8 markers are useful in defining the function of each type.

Helper t cells and their cytokines

Helper T cells (Th) , bearing the CD4 molecule, function by secreting cytokines that act to enhance other immune responses. There are two classes of Th cells, and they act on different components of the immune response. These cells are not distinguished by their surface molecules but by the characteristic set of cytokines they secrete ( [link] ).

Th1 cells    are a type of helper T cell that secretes cytokines that regulate the immunological activity and development of a variety of cells, including macrophages and other types of T cells.

Th2 cells    , on the other hand, are cytokine-secreting cells that act on B cells to drive their differentiation into plasma cells that make antibody. In fact, T cell help is required for antibody responses to most protein antigens, and these are called T cell-dependent antigens.

Cytotoxic t cells

Cytotoxic T cells (Tc) are T cells that kill target cells by inducing apoptosis using the same mechanism as NK cells. They either express Fas ligand, which binds to the fas molecule on the target cell, or act by using perforins and granzymes contained in their cytoplasmic granules. As was discussed earlier with NK cells, killing a virally infected cell before the virus can complete its replication cycle results in the production of no infectious particles. As more Tc cells are developed during an immune response, they overwhelm the ability of the virus to cause disease. In addition, each Tc cell can kill more than one target cell, making them especially effective. Tc cells are so important in the antiviral immune response that some speculate that this was the main reason the adaptive immune response evolved in the first place.

Regulatory t cells

Regulatory T cells (Treg) , or suppressor T cells, are the most recently discovered of the types listed here, so less is understood about them. In addition to CD4, they bear the molecules CD25 and FOXP3. Exactly how they function is still under investigation, but it is known that they suppress other T cell immune responses. This is an important feature of the immune response, because if clonal expansion during immune responses were allowed to continue uncontrolled, these responses could lead to autoimmune diseases and other medical issues.

Not only do T cells directly destroy pathogens, but they regulate nearly all other types of the adaptive immune response as well, as evidenced by the functions of the T cell types, their surface markers, the cells they work on, and the types of pathogens they work against (see [link] ).

Functions of T Cell Types and Their Cytokines
T cell Main target Function Pathogen Surface marker MHC Cytokines or mediators
Tc Infected cells Cytotoxicity Intracellular CD8 Class I Perforins, granzymes, and fas ligand
Th1 Macrophage Helper inducer Extracellular CD4 Class II Interferon-γ and TGF-β
Th2 B cell Helper inducer Extracellular CD4 Class II IL-4, IL-6, IL-10, and others
Treg Th cell Suppressor None CD4, CD25 ? TGF-β and IL-10

Chapter review

T cells recognize antigens with their antigen receptor, a complex of two protein chains on their surface. They do not recognize self-antigens, however, but only processed antigen presented on their surfaces in a binding groove of a major histocompatibility complex molecule. T cells develop in the thymus, where they learn to use self-MHC molecules to recognize only foreign antigens, thus making them tolerant to self-antigens. There are several functional types of T lymphocytes, the major ones being helper, regulatory, and cytotoxic T cells.

Questions & Answers

why human blood pressure high
amin Reply
What is red blood cell
HANNAH Reply
A type of blood cell that is made in the bone marrow and found in the blood. Red blood cells contain a protein called hemoglobin, which carries oxygen from the lungs to all parts of the body. Checking the number of red blood cells in the blood is usually part of a complete blood cell (CBC) test. It
Noor
red blood cell are the most numerous blood cells.they comprise about 99% of all blood cells red blood cells are non nucleated it has red colour due to present to hemoglobin.
Vineeta
Thanks for the answers
HANNAH
how will you promote quality of life in ptb patient using the 14 basic needs and 21 nursing problems?
rOx Reply
coronary circulation ?
Juri Reply
Coronary circulation is the circulation of blood in the blood vessels that supply the heart muscle (myocardium). Coronary arteries supply oxygenated blood to the heart muscle, and cardiac veins drain away the blood once it has been deoxygenated. Because the rest of the body.
Riyaz
coronary circulation ,is flow of blood that supplies the heart tissue itself is the coronary circulation. the functional blood supply of the heart,is the shortest circulation in tha body.
Vineeta
what about the easy way to understand action potential
Bright
event of cardiac cycle
Juri Reply
hii
Chandan
whatisanatom
kaso Reply
anatomy is the scientific way of studying the body structure.
cynthia
the branch of science concerned with the bodily structure of humans, animals, and other living organisms, especially as revealed by dissection and the separation of parts.
Noor
what is means by LAPE and HAPE
Noor
guys i've question what occur when homeostasis balance mechanisms lost
cris Reply
Bladder is blank to the small intestine, what is the right directional term for that?
Julaika Reply
When peristaltic movement is correct.
Farid
what tissue that support body organ?
Sabrina Reply
the skeleton
veronica
Skeleton
GEBAH
skeleton
Juwita
skeleton
Farid
skeleton
Priya
skeleton
Emmanuel
skeleton
Noor
skeleton
BILAL
skeleton
hanuman
how many bones are there in the body
hanuman Reply
go uuu
Prasad
206
Prasad
206
Nelago
206
Esmeralda
206
Joey
baby me 360. and human body 206.found bones.....
Sneha
what is a tissue in Anatomy and physiology
Nelago
206 bones
Juwita
what is an example of a molecule that can directly pass through the phospholipid bilayer of the plasma membrane?
Kathy
206
Johara
how many bones are there in the hand and wrist
hanuman
200 tissue
hanuman
answer 206 bones
GEBAH
axial 80 appendicular 126 total bone is 206
Vineeta
wrist bone 8
Vineeta
baby bone 270 he is correct answer
hanuman
Jo carpus wrist bone h
Vineeta
206
Musonda
206 bones in human body.
Farid
What is Heart attack?
Farid
206
Priti
206 all
Sa
All 206
Sa
A heart attack happens when the flow of oxygen-rich blood to a section of heart muscle suddenly becomes blocked and the heart can't get oxygen. If blood flow isn't restored quickly, the section of heart muscle begins to die. Heart attack treatment works best when it's given right after symptoms occu
Riyaz
how can l understand Anatomy quickly?
Agness Reply
you can't!!!! Anatomy is easy but the physiology takes time to understand. Anatomy is simply systems and organs but you must take time to learn physiology to understand how the anatomy works
Rachael
alright.. so how can l at least memorize the information about physiology?
Agness
what name is given to the fluid that is drawn from the villi to the lymphatic vessels
margaret Reply
I think venous
Noor
lymph
Rachael
I also think it's lymph
Akhi
me too I think lymph
Esmeralda
ans Rhythmic contraction
GEBAH
what are the ten (10) rights for drug administration
GEBAH
importance of muscle in the anatomical structures.
Akomeng Reply
it permits the constant level of movement,and gives structure and shape to the body
Priya
what is assimilation
Asiimwe Reply
cellular level organism level chemical level organ system level tissue level organ level
Aleah Reply
, the current topic
Hilya
cellular level
Priya
tissue level
Priya
organ level
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organ systems level
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organism level
Priya

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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