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Exercise 1 Enter the letter of any compound that does not meet the structural requirements for the aldol condensation:

Answer: C, F etc……. (Convince yourself)

Exercise 2 Write the letter of any β size 12{β} {} -hydroxyaldehyde or β size 12{β} {} - hydroxyketone?

Answer: B, D etc…….. (Convince yourself)

Exercise 3 Each of the following compounds was prepared by an aldol condensation followed by dehydration. In each case, select the structure of the starting material from the list of choices in the box below.

Answer: (a) FF (b) BB (c) __? __ (Convince yourself)

Exercise 4 Each of the following compounds was prepared by a crossed aldol condensation followed by dehydration. In each case, select the structures of the starting materials from the list of choices in the box above. Enter the letter of the compound that serves as the nucleophilic component followed by that of the electrophilic component. For example, the nucleophilic component used to prepare the first compound is A, while the electrophilic component is F.

Answers: (a) AF (b)

Pre-lab 2: aldol condensation (total 10 points)

Click here for the Pre-Lab

Name(Print then sign): ___________________________________________________

Lab Day: ___________________Section: ________TA__________________________

This assignment must be completed individually and turned in to your TA at the beginning of lab. You will not be allowed to begin the lab until you have completed this assignment.

1) Is this reaction acid or base catalyzed? Why do you need to use 1.0 M HCl at the end of the experiment? (2 points)

2) What is the role of p-nitro group in 4-nitrobenzaldehyde during the ALDOL reaction? What do you think would happen to the yield of the product if p-methoxy group was present instead of p-nitro group? (2 points)

3) Benzaldehyde (PhCHO) cannot undergo“ALDOL”reaction by itself in presence of strong base (KOH)-Why? (1 point)

4) Write the major product of the following reactions, if there is no product specifies it. (1+2+2 = 5 points)


You will be assessed on:

  • Completion of Pre lab questions.
  • Write-up in your Lab Notebook (see Appendix:1 Lab Notebook Guidelines )
  • Completion of Report questions.
  • TA evaluation of lab procedure.

Materials required

Equipment Chemicals

  • Water Bath 4-nitrobenzaldehyde
  • Stir bar Acetophenone
  • Round bottom flask (10mL) Sodium hydroxide
  • Funnel HCl (1.0 M)
  • Beaker Ethanol
  • Glass rod (for recrystalization) Filter paper


Wear gloves all the time, especially when working with NaOH and HCl. Keep safety glasses at all the times.

Experimental procedure

You will be assigned either procedure A (traditional experiment procedures) or procedure B (green chemistry experiment procedures). Comparison of two methods: Give percent yield and melting point temperatures to the TA so that they can be written on the board and you can then collect everyones’data.

A. traditional experiment procedure

Pre-heat your water bath to 60-70°C.

  • Place a stir bar and 0.4 g of 4-nitrobenzaldehyde, 0.3 g of acetophenone and 0.10 g of sodium hydroxide in a 10 mL round bottom flask. NOTE: Acetophenone is a liquid with a density of 1.03 g/mL. Add 3.5 mL of 95% ethanol and heat the reaction mixture to 60-70°C while stirring for 20 minutes. Do not overheat your product otherwise you will polymerize your sample.

Questions & Answers

Is there any normative that regulates the use of silver nanoparticles?
Damian Reply
what king of growth are you checking .?
What fields keep nano created devices from performing or assimulating ? Magnetic fields ? Are do they assimilate ?
Stoney Reply
why we need to study biomolecules, molecular biology in nanotechnology?
Adin Reply
yes I'm doing my masters in nanotechnology, we are being studying all these domains as well..
what school?
biomolecules are e building blocks of every organics and inorganic materials.
anyone know any internet site where one can find nanotechnology papers?
Damian Reply
sciencedirect big data base
Introduction about quantum dots in nanotechnology
Praveena Reply
what does nano mean?
Anassong Reply
nano basically means 10^(-9). nanometer is a unit to measure length.
do you think it's worthwhile in the long term to study the effects and possibilities of nanotechnology on viral treatment?
Damian Reply
absolutely yes
how to know photocatalytic properties of tio2 nanoparticles...what to do now
Akash Reply
it is a goid question and i want to know the answer as well
characteristics of micro business
for teaching engĺish at school how nano technology help us
Do somebody tell me a best nano engineering book for beginners?
s. Reply
there is no specific books for beginners but there is book called principle of nanotechnology
what is fullerene does it is used to make bukky balls
Devang Reply
are you nano engineer ?
fullerene is a bucky ball aka Carbon 60 molecule. It was name by the architect Fuller. He design the geodesic dome. it resembles a soccer ball.
what is the actual application of fullerenes nowadays?
That is a great question Damian. best way to answer that question is to Google it. there are hundreds of applications for buck minister fullerenes, from medical to aerospace. you can also find plenty of research papers that will give you great detail on the potential applications of fullerenes.
what is the Synthesis, properties,and applications of carbon nano chemistry
Abhijith Reply
Mostly, they use nano carbon for electronics and for materials to be strengthened.
is Bucky paper clear?
carbon nanotubes has various application in fuel cells membrane, current research on cancer drug,and in electronics MEMS and NEMS etc
so some one know about replacing silicon atom with phosphorous in semiconductors device?
s. Reply
Yeah, it is a pain to say the least. You basically have to heat the substarte up to around 1000 degrees celcius then pass phosphene gas over top of it, which is explosive and toxic by the way, under very low pressure.
Do you know which machine is used to that process?
how to fabricate graphene ink ?
for screen printed electrodes ?
What is lattice structure?
s. Reply
of graphene you mean?
or in general
in general
Graphene has a hexagonal structure
On having this app for quite a bit time, Haven't realised there's a chat room in it.
what is biological synthesis of nanoparticles
Sanket Reply
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