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Exercise 1 Enter the letter of any compound that does not meet the structural requirements for the aldol condensation:

Answer: C, F etc……. (Convince yourself)

Exercise 2 Write the letter of any β size 12{β} {} -hydroxyaldehyde or β size 12{β} {} - hydroxyketone?

Answer: B, D etc…….. (Convince yourself)

Exercise 3 Each of the following compounds was prepared by an aldol condensation followed by dehydration. In each case, select the structure of the starting material from the list of choices in the box below.

Answer: (a) FF (b) BB (c) __? __ (Convince yourself)

Exercise 4 Each of the following compounds was prepared by a crossed aldol condensation followed by dehydration. In each case, select the structures of the starting materials from the list of choices in the box above. Enter the letter of the compound that serves as the nucleophilic component followed by that of the electrophilic component. For example, the nucleophilic component used to prepare the first compound is A, while the electrophilic component is F.

Answers: (a) AF (b)

Pre-lab 2: aldol condensation (total 10 points)

Click here for the Pre-Lab

Name(Print then sign): ___________________________________________________

Lab Day: ___________________Section: ________TA__________________________

This assignment must be completed individually and turned in to your TA at the beginning of lab. You will not be allowed to begin the lab until you have completed this assignment.

1) Is this reaction acid or base catalyzed? Why do you need to use 1.0 M HCl at the end of the experiment? (2 points)

2) What is the role of p-nitro group in 4-nitrobenzaldehyde during the ALDOL reaction? What do you think would happen to the yield of the product if p-methoxy group was present instead of p-nitro group? (2 points)

3) Benzaldehyde (PhCHO) cannot undergo“ALDOL”reaction by itself in presence of strong base (KOH)-Why? (1 point)

4) Write the major product of the following reactions, if there is no product specifies it. (1+2+2 = 5 points)

Grading

You will be assessed on:

  • Completion of Pre lab questions.
  • Write-up in your Lab Notebook (see Appendix:1 Lab Notebook Guidelines )
  • Completion of Report questions.
  • TA evaluation of lab procedure.

Materials required

Equipment Chemicals

  • Water Bath 4-nitrobenzaldehyde
  • Stir bar Acetophenone
  • Round bottom flask (10mL) Sodium hydroxide
  • Funnel HCl (1.0 M)
  • Beaker Ethanol
  • Glass rod (for recrystalization) Filter paper

Safety

Wear gloves all the time, especially when working with NaOH and HCl. Keep safety glasses at all the times.

Experimental procedure

You will be assigned either procedure A (traditional experiment procedures) or procedure B (green chemistry experiment procedures). Comparison of two methods: Give percent yield and melting point temperatures to the TA so that they can be written on the board and you can then collect everyones’data.

A. traditional experiment procedure

Pre-heat your water bath to 60-70°C.

  • Place a stir bar and 0.4 g of 4-nitrobenzaldehyde, 0.3 g of acetophenone and 0.10 g of sodium hydroxide in a 10 mL round bottom flask. NOTE: Acetophenone is a liquid with a density of 1.03 g/mL. Add 3.5 mL of 95% ethanol and heat the reaction mixture to 60-70°C while stirring for 20 minutes. Do not overheat your product otherwise you will polymerize your sample.

Questions & Answers

are nano particles real
Missy Reply
yeah
Joseph
Hello, if I study Physics teacher in bachelor, can I study Nanotechnology in master?
Lale Reply
no can't
Lohitha
where we get a research paper on Nano chemistry....?
Maira Reply
nanopartical of organic/inorganic / physical chemistry , pdf / thesis / review
Ali
what are the products of Nano chemistry?
Maira Reply
There are lots of products of nano chemistry... Like nano coatings.....carbon fiber.. And lots of others..
learn
Even nanotechnology is pretty much all about chemistry... Its the chemistry on quantum or atomic level
learn
Google
da
no nanotechnology is also a part of physics and maths it requires angle formulas and some pressure regarding concepts
Bhagvanji
hey
Giriraj
Preparation and Applications of Nanomaterial for Drug Delivery
Hafiz Reply
revolt
da
Application of nanotechnology in medicine
has a lot of application modern world
Kamaluddeen
yes
narayan
what is variations in raman spectra for nanomaterials
Jyoti Reply
ya I also want to know the raman spectra
Bhagvanji
I only see partial conversation and what's the question here!
Crow Reply
what about nanotechnology for water purification
RAW Reply
please someone correct me if I'm wrong but I think one can use nanoparticles, specially silver nanoparticles for water treatment.
Damian
yes that's correct
Professor
I think
Professor
Nasa has use it in the 60's, copper as water purification in the moon travel.
Alexandre
nanocopper obvius
Alexandre
what is the stm
Brian Reply
is there industrial application of fullrenes. What is the method to prepare fullrene on large scale.?
Rafiq
industrial application...? mmm I think on the medical side as drug carrier, but you should go deeper on your research, I may be wrong
Damian
How we are making nano material?
LITNING Reply
what is a peer
LITNING Reply
What is meant by 'nano scale'?
LITNING Reply
What is STMs full form?
LITNING
scanning tunneling microscope
Sahil
how nano science is used for hydrophobicity
Santosh
Do u think that Graphene and Fullrene fiber can be used to make Air Plane body structure the lightest and strongest. Rafiq
Rafiq
what is differents between GO and RGO?
Mahi
what is simplest way to understand the applications of nano robots used to detect the cancer affected cell of human body.? How this robot is carried to required site of body cell.? what will be the carrier material and how can be detected that correct delivery of drug is done Rafiq
Rafiq
if virus is killing to make ARTIFICIAL DNA OF GRAPHENE FOR KILLED THE VIRUS .THIS IS OUR ASSUMPTION
Anam
analytical skills graphene is prepared to kill any type viruses .
Anam
Any one who tell me about Preparation and application of Nanomaterial for drug Delivery
Hafiz
what is Nano technology ?
Bob Reply
write examples of Nano molecule?
Bob
The nanotechnology is as new science, to scale nanometric
brayan
nanotechnology is the study, desing, synthesis, manipulation and application of materials and functional systems through control of matter at nanoscale
Damian
Is there any normative that regulates the use of silver nanoparticles?
Damian Reply
what king of growth are you checking .?
Renato
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Source:  OpenStax, Chem217labsfall07. OpenStax CNX. Oct 16, 2007 Download for free at http://cnx.org/content/col10463/1.4
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