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Certain hormones, such as androgens, epinephrine, thyroid hormones, and growth hormone, can affect the oxygen–hemoglobin saturation/disassociation curve by stimulating the production of a compound called 2,3-bisphosphoglycerate (BPG) by erythrocytes. BPG is a byproduct of glycolysis. Because erythrocytes do not contain mitochondria, glycolysis is the sole method by which these cells produce ATP. BPG promotes the disassociation of oxygen from hemoglobin. Therefore, the greater the concentration of BPG, the more readily oxygen dissociates from hemoglobin, despite its partial pressure.

The pH of the blood is another factor that influences the oxygen–hemoglobin saturation/dissociation curve (see [link] ). The Bohr effect    is a phenomenon that arises from the relationship between pH and oxygen’s affinity for hemoglobin: A lower, more acidic pH promotes oxygen dissociation from hemoglobin. In contrast, a higher, or more basic, pH inhibits oxygen dissociation from hemoglobin. The greater the amount of carbon dioxide in the blood, the more molecules that must be converted, which in turn generates hydrogen ions and thus lowers blood pH. Furthermore, blood pH may become more acidic when certain byproducts of cell metabolism, such as lactic acid, carbonic acid, and carbon dioxide, are released into the bloodstream.

Hemoglobin of the fetus

The fetus has its own circulation with its own erythrocytes; however, it is dependent on the mother for oxygen. Blood is supplied to the fetus by way of the umbilical cord, which is connected to the placenta and separated from maternal blood by the chorion. The mechanism of gas exchange at the chorion is similar to gas exchange at the respiratory membrane. However, the partial pressure of oxygen is lower in the maternal blood in the placenta, at about 35 to 50 mm Hg, than it is in maternal arterial blood. The difference in partial pressures between maternal and fetal blood is not large, as the partial pressure of oxygen in fetal blood at the placenta is about 20 mm Hg. Therefore, there is not as much diffusion of oxygen into the fetal blood supply. The fetus’ hemoglobin overcomes this problem by having a greater affinity for oxygen than maternal hemoglobin ( [link] ). Both fetal and adult hemoglobin have four subunits, but two of the subunits of fetal hemoglobin have a different structure that causes fetal hemoglobin to have a greater affinity for oxygen than does adult hemoglobin.

Oxygen-hemoglobin dissociation curves in fetus and adult

This graph shows the oxygen saturation versus the partial pressure of oxygen in fetal hemoglobin and adult hemoglobin.
Fetal hemoglobin has a greater affinity for oxygen than does adult hemoglobin.

Carbon dioxide transport in the blood

Carbon dioxide is transported by three major mechanisms. The first mechanism of carbon dioxide transport is by blood plasma, as some carbon dioxide molecules dissolve in the blood. The second mechanism is transport in the form of bicarbonate (HCO 3 ), which also dissolves in plasma. The third mechanism of carbon dioxide transport is similar to the transport of oxygen by erythrocytes ( [link] ).

Carbon dioxide transport

This figure shows how carbon dioxide is transported from the tissue to the red blood cell.
Carbon dioxide is transported by three different methods: (a) in erythrocytes; (b) after forming carbonic acid (H 2 CO 3 ), which is dissolved in plasma; (c) and in plasma.

Questions & Answers

what is Anatomy
Hannah Reply
because she's not yet at term
Nansi Reply
what is physiology?
Grace Reply
what is physiology
David
Physiology is the study of the functions of the human body
Hannah
am a new one!!
sekela
what is Homeopathy
AHMED
Name three reasons to study anatomy and physiology
Hills Reply
Why do we need to study anatomy and physiology
Hills Reply
I want to study human anatomy
Ibrahim
What is anatomy
Christabel Reply
anatomy is the branch of medicine in which we study structure and part of the body
Ansar
The art of studying the different parts of any organized body, to discover their situation, structure, and economy; dissection.
ChristMas
anatomy is the study of structures that make up the body and how they re realated to each other
BRIAN
Anatomy is the study of structures of the body and shape of the body and body parts and their relationship to one another.
Abubakar
what is the importance of anatomy
Emeria Reply
cockroch ka sir katne ke bad o jinda kyu rahta
Anil
it helps us to understand the function of human metabolic system and also who these systems works which system play what role and so on
Nouman
It's help us to know the structure, functions and relationship of the human body
Nansi
it helps us to appreciate how the internal structures works
Damilola
Anatomy opens up to us the structures of the various parts of the human body and correlates them to their specific function respectively
Michael
Anatomy is helps us understand and explore much about human structures
Chuks
systemic anatomy in short
Puja Reply
systemic circulation is the circulation in which heart supplies oxygenated blood to cells of body and takes deoxygenated blood away from body to heart
Ajeet
really?
Puja
yeah
BRIAN
ha ji
Ajeet
well much setisfy
Nouman
hello
Limpo
am new here
Limpo
ok
Emeria
am new here
Sindazi
I'm new as well
Crystal
who ask the question about cockroach cutting head
Nouman
the answer is They have an open circulatory system, which there's much less pressure in.After you cut their heads off very often their necks would seal off just by clotting," he adds. "There's no uncontrolled bleeding.The hardy vermin breathe through spiracles, or little holes in each body se
Nouman
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Sindazi
well it's up-to you how you utilities this
Nouman
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Puja
hello
AKARAJ
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AKARAJ
I think it is helpful
Alfred
Hi
Christabel
hi
Sachin
how do plateletes function in blood clotting
lydia
what are the function of the cell membrane
Elias Reply
the cell membrane helps in allowing and removing substances from the cell. it also aid in protecting the cell and giving it a definite shape.
veezy
The cell membrane is made up of a semipermeable lipid bi-layer which helps to regulate the kind of materials that enters it through active transport and passive diffusion.
Michael
properties of cardiac muscle
hotlan Reply
Myogenic,contain intercalated disc,control involuntary,fond in the heart walls only
AMOS
The exclusive characteristics of heart muscle is consists of Intercalated disc.
Doctor
Among the involuntary muscles only cardiac muscle is Myogenic but rest of involuntary muscles is Neurogenic.
Doctor
What about the exclusive characteristics of smooth muscle apart from lacking myofibrils in it's structure?
AMOS
What is the different between neurogenic and carcinogenic?
AMOS
distinguish between anatomy and physiology
Jonah Reply
Anatomy is the study of body parts and were they are found, physiology is the study of body parts and their functions
Alex
Anatomy is the scientific study of the body structure. While Physiology is the scientific study of the body function
Ossy
Anatomy is te scientic study of body parts and their physical relationship between different systems while physiology is te study of how all body systems works.
AMOS
1, molecules 2, cells 3, organ 4, tissue 5, organ systems 6l, organisms
hamisu Reply
hi
Musaffa
i m new here
Musaffa
hii
Coolx
hi
mushahid
how are you all
mushahid
Am fine bro and you
Nyier
Fine us all
AMOS
smallest part in anatomy
Mood Reply
functions of respiratory system
Dorice Reply
2. If the respiratory rate increases, carbon dioxide is removed from the blood, what effect would this have on blood hydrogen ion levels?
cris Reply
_____________are cells from fibrils and are active in the repair of tissue.
cris

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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