# 8.7 Mathematical modeling of hippocampal spatial memory with place

 Page 1 / 6
This report summarizes work done as part of the Modeling Spatial Memory with Place Cells PFUG under Rice University's VIGRE program. VIGRE is a program of Vertically Integrated Grants for Research and Education in the Mathematical Sciences under the direction of the National Science Foundation. A PFUG is a group of Postdocs, Faculty, Undergraduates and Graduate students formed round the study of a common problem. This work was studied in the Rice University VIGRE program in the Summer of 2011. In this module, we mathematically model Kneirim's Double Rotation Experiment with a model given by Cox and Gabbiani and analytically discuss the relation between overlapping place fields and synaptic input weights.

## Biology

Spatial memory is what allows us to keep track of our location in space by making mental maps of each environment. Let's consider what happens in the brain during the process of forming these internal maps.

Connections, called synapses, between certain neurons strengthen or weaken–a process known as synaptic plasticity. The strength, or weight, of a synapse controls how much one neuron can affect another. Synaptic plasticity is necessary for memory formation [link] .

While many neurons are involved with spatial memory, our focus is upon neurons in the hippocampus called place cells [link] . Place cells have a unique firing pattern. When an environment becomes familiar, each place cell becomes associated with one area of the environment. In other words, after repeated exposure to one environment, a place cell will come to spike in only one area of the environment, which is called that cell's place field [link] . See [link] .

Due to place cells' characteristic firing pattern where a cell has a single place field in each environment, it is easy to test if a rat recognizes the environment they have been placed in by examining place cell activity.

## Motivation: double rotation experiment

Our research on place cells is based off of the Double Rotation Experiment (DRE) conducted by our collaborator Dr. Knierim [link] .

how can chip be made from sand
is this allso about nanoscale material
Almas
are nano particles real
yeah
Joseph
Hello, if I study Physics teacher in bachelor, can I study Nanotechnology in master?
no can't
Lohitha
where is the latest information on a no technology how can I find it
William
currently
William
where we get a research paper on Nano chemistry....?
nanopartical of organic/inorganic / physical chemistry , pdf / thesis / review
Ali
what are the products of Nano chemistry?
There are lots of products of nano chemistry... Like nano coatings.....carbon fiber.. And lots of others..
learn
Even nanotechnology is pretty much all about chemistry... Its the chemistry on quantum or atomic level
learn
da
no nanotechnology is also a part of physics and maths it requires angle formulas and some pressure regarding concepts
Bhagvanji
hey
Giriraj
Preparation and Applications of Nanomaterial for Drug Delivery
revolt
da
Application of nanotechnology in medicine
has a lot of application modern world
Kamaluddeen
yes
narayan
what is variations in raman spectra for nanomaterials
ya I also want to know the raman spectra
Bhagvanji
I only see partial conversation and what's the question here!
what about nanotechnology for water purification
please someone correct me if I'm wrong but I think one can use nanoparticles, specially silver nanoparticles for water treatment.
Damian
yes that's correct
Professor
I think
Professor
Nasa has use it in the 60's, copper as water purification in the moon travel.
Alexandre
nanocopper obvius
Alexandre
what is the stm
is there industrial application of fullrenes. What is the method to prepare fullrene on large scale.?
Rafiq
industrial application...? mmm I think on the medical side as drug carrier, but you should go deeper on your research, I may be wrong
Damian
How we are making nano material?
what is a peer
What is meant by 'nano scale'?
What is STMs full form?
LITNING
scanning tunneling microscope
Sahil
how nano science is used for hydrophobicity
Santosh
Do u think that Graphene and Fullrene fiber can be used to make Air Plane body structure the lightest and strongest. Rafiq
Rafiq
what is differents between GO and RGO?
Mahi
what is simplest way to understand the applications of nano robots used to detect the cancer affected cell of human body.? How this robot is carried to required site of body cell.? what will be the carrier material and how can be detected that correct delivery of drug is done Rafiq
Rafiq
if virus is killing to make ARTIFICIAL DNA OF GRAPHENE FOR KILLED THE VIRUS .THIS IS OUR ASSUMPTION
Anam
analytical skills graphene is prepared to kill any type viruses .
Anam
Any one who tell me about Preparation and application of Nanomaterial for drug Delivery
Hafiz
what is Nano technology ?
write examples of Nano molecule?
Bob
The nanotechnology is as new science, to scale nanometric
brayan
nanotechnology is the study, desing, synthesis, manipulation and application of materials and functional systems through control of matter at nanoscale
Damian
Got questions? Join the online conversation and get instant answers!