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How bones grow in length

The epiphyseal plate is the area of growth in a long bone. It is a layer of hyaline cartilage where ossification occurs in immature bones. On the epiphyseal side of the epiphyseal plate, cartilage is formed. On the diaphyseal side, cartilage is ossified, and the diaphysis grows in length. The epiphyseal plate is composed of four zones of cells and activity ( [link] ). The reserve zone    is the region closest to the epiphyseal end of the plate and contains small chondrocytes within the matrix. These chondrocytes do not participate in bone growth but secure the epiphyseal plate to the osseous tissue of the epiphysis.

Longitudinal bone growth

This illustration shows the zones bordering the epiphyseal plate of the epiphysis. The topmost layer of the epiphysis is the reserve zone, which is colored blue because it is made of cartilage. Two arteries are shown travelling through this zone to supply nutrients to the second zone: the proliferative zone. Here, five chondrocytes are undergoing mitosis. They continually divide, producing five long rows of chondrocytes. The next zone is the zone of maturation and hypertrophy. Here, lipids, glycogen and alkaline phosphatase accumulate, causing the cartilaginous matrix to calcify. This zone consists of five rows of ten chondrocytes which are increasing in size as one moves down a row. The next zone is the calcified matrix. Here, the chondrocytes have hardened and die as the matrix around them has calcified. The bottommost row is the zone of ossification. This zone is actually part of the metaphysis. Arteries from the metaphysis branch through the newly-formed trabeculae in this zone. The newly deposited bone tissue at the top of the zone of ossification is called the primary spongiosa. The older bone at the bottom of the zone of ossification is labeled the secondary spongiosa.
The epiphyseal plate is responsible for longitudinal bone growth.

The proliferative zone    is the next layer toward the diaphysis and contains stacks of slightly larger chondrocytes. It makes new chondrocytes (via mitosis) to replace those that die at the diaphyseal end of the plate. Chondrocytes in the next layer, the zone of maturation and hypertrophy    , are older and larger than those in the proliferative zone. The more mature cells are situated closer to the diaphyseal end of the plate. The longitudinal growth of bone is a result of cellular division in the proliferative zone and the maturation of cells in the zone of maturation and hypertrophy.

Most of the chondrocytes in the zone of calcified matrix    , the zone closest to the diaphysis, are dead because the matrix around them has calcified. Capillaries and osteoblasts from the diaphysis penetrate this zone, and the osteoblasts secrete bone tissue on the remaining calcified cartilage. Thus, the zone of calcified matrix connects the epiphyseal plate to the diaphysis. A bone grows in length when osseous tissue is added to the diaphysis.

Bones continue to grow in length until early adulthood. The rate of growth is controlled by hormones, which will be discussed later. When the chondrocytes in the epiphyseal plate cease their proliferation and bone replaces the cartilage, longitudinal growth stops. All that remains of the epiphyseal plate is the epiphyseal line    ( [link] ).

Progression from epiphyseal plate to epiphyseal line

This illustration shows anterior views of a right and left femur. The left femur possesses a growth plate at the border of its distal metaphysis and distal epiphysis. The proximal epiphysis has two growth plates. The first is located below the head of the femur while the second is located below the trochanter, which is the bump on the lateral side of the femur. The right femur has the same plates as the left femur. However, the left femur represents a mature long bone. Here, growth is completed and the epiphyseal plate has degraded to a thin, faint, epiphyseal line.
As a bone matures, the epiphyseal plate progresses to an epiphyseal line. (a) Epiphyseal plates are visible in a growing bone. (b) Epiphyseal lines are the remnants of epiphyseal plates in a mature bone.

How bones grow in diameter

While bones are increasing in length, they are also increasing in diameter; growth in diameter can continue even after longitudinal growth ceases. This is called appositional growth. Osteoclasts resorb old bone that lines the medullary cavity, while osteoblasts, via intramembranous ossification, produce new bone tissue beneath the periosteum. The erosion of old bone along the medullary cavity and the deposition of new bone beneath the periosteum not only increase the diameter of the diaphysis but also increase the diameter of the medullary cavity. This process is called modeling    .

Bone remodeling

The process in which matrix is resorbed on one surface of a bone and deposited on another is known as bone modeling. Modeling primarily takes place during a bone’s growth. However, in adult life, bone undergoes remodeling    , in which resorption of old or damaged bone takes place on the same surface where osteoblasts lay new bone to replace that which is resorbed. Injury, exercise, and other activities lead to remodeling. Those influences are discussed later in the chapter, but even without injury or exercise, about 5 to 10 percent of the skeleton is remodeled annually just by destroying old bone and renewing it with fresh bone.

Diseases of the…

Skeletal system

Osteogenesis imperfecta (OI) is a genetic disease in which bones do not form properly and therefore are fragile and break easily. It is also called brittle bone disease. The disease is present from birth and affects a person throughout life.

The genetic mutation that causes OI affects the body’s production of collagen, one of the critical components of bone matrix. The severity of the disease can range from mild to severe. Those with the most severe forms of the disease sustain many more fractures than those with a mild form. Frequent and multiple fractures typically lead to bone deformities and short stature. Bowing of the long bones and curvature of the spine are also common in people afflicted with OI. Curvature of the spine makes breathing difficult because the lungs are compressed.

Because collagen is such an important structural protein in many parts of the body, people with OI may also experience fragile skin, weak muscles, loose joints, easy bruising, frequent nosebleeds, brittle teeth, blue sclera, and hearing loss. There is no known cure for OI. Treatment focuses on helping the person retain as much independence as possible while minimizing fractures and maximizing mobility. Toward that end, safe exercises, like swimming, in which the body is less likely to experience collisions or compressive forces, are recommended. Braces to support legs, ankles, knees, and wrists are used as needed. Canes, walkers, or wheelchairs can also help compensate for weaknesses.

When bones do break, casts, splints, or wraps are used. In some cases, metal rods may be surgically implanted into the long bones of the arms and legs. Research is currently being conducted on using bisphosphonates to treat OI. Smoking and being overweight are especially risky in people with OI, since smoking is known to weaken bones, and extra body weight puts additional stress on the bones.

Watch this video to see how a bone grows.

Chapter review

All bone formation is a replacement process. Embryos develop a cartilaginous skeleton and various membranes. During development, these are replaced by bone during the ossification process. In intramembranous ossification, bone develops directly from sheets of mesenchymal connective tissue. In endochondral ossification, bone develops by replacing hyaline cartilage. Activity in the epiphyseal plate enables bones to grow in length. Modeling allows bones to grow in diameter. Remodeling occurs as bone is resorbed and replaced by new bone. Osteogenesis imperfecta is a genetic disease in which collagen production is altered, resulting in fragile, brittle bones.

Questions & Answers

demand and supply rules
jamac Reply
compative demand and supply
jamac
compare demand and supply
jamac
what are simple epithelial tissues
Ushie Reply
is a type of tissue which covers the external and internal part of the body
Fatou
more information would be better understanding.
Tasha
what is platelets
Lilian Reply
platelet is also known as thrombocyte.thrombo means clot.it is a formed element of blood formed from fragment of megakaryocyte surrounded by plasma membrane in the redbone marow
Adeyemo
what is diabetes insipidus
namrata Reply
it is an infection due to less or no secretion of ADH characterized by excretion of dilute urine
Meshack
Infection? I don't think any form of diabetes, whether it's mellitus or insipidus, is caused by an infection.
Matias
ya
Akanyijuka
it is the disorder of salt & water metabolism
Emma
diabetes inspidus is a condition were the liver can't produce insulin to convert the excess sugar to glycogen.
mangs
sorry that is for diabetes mellitus
mangs
what is septal cartilage
Arthur Reply
I don't understand please
Esther Reply
hey
Austine
good evening boss
Austine
Evening
Esther
good evening
Melissa
evening
Vitus
hi
Rodgers
good morning
Aurelia
hello
Helsa
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Aurelia
Philippines
Helsa
im from india
Aurelia
Hello
Amos
why
Sami
wat
Rodgers
what's that
Gift
what's the medulla?
alhussiney Reply
The medulla oblongata or simply medulla is a long stem-like structure which makes up the lower part of the brainstem. It is anterior and partially inferior to the cerebellum
Ludmila
define bone in simple terms
Mhoses Reply
bones are made up by collagen and calcium phosphate
Aurelia
yes
Confidence
Bones are the hard large calcareous connective tissue of which the adult skeleton of most vertebrates is chiefly composed
Olalekan
Bone is the substance that forms skeleton
Frances
good morning
Mrinal
Skelton muscles is any disorder of calcium
Mrinal
Bones protect the various organs of the body
Celina
Bone is a hard strong and durable type of connective tissue
Bkv
bone is a hard, calcareous connective tissue which gives structural support to the body and helpless in its locomotion!
Divya
It also is the main site for synthesis of the RBCs
Divya
thanks for your answers
Mhoses
A diagram of epithelial tissue
Emmanuel Reply
What does the urinary regulate blood pressure
Jennifer Reply
functions of melatonin
marion Reply
d. inversely proportional
John Reply
Airway resistance in the human lung is? a. Greatest in the generation of distal bronchioles in healthy people because these airways have the smallest radii b. Not increased during a forced expiration in a healthy subject c. Decreased when breathing through the mouth d. Inversely proportional
Maryam Reply
1. Chemical level 2. Cellular level 3.Tissue level 4. Organ level 5.Organ system level 5.Organismal level
Jamela Reply
d
HMD
High
HMD
hlw
Maryam
------is not a content of femoral canal? a. Fatty tissue b. Femoral nerve c. Lymph vessels d. Lymph node
Maryam
a
Alhassan
why there is bleeding in menstruation?
KUHELI Reply
menopause
Vasu
no
KUHELI
no one ready to help me
Maryam
skin
The following hormones increase the blood glucose level except_____________? a. Parathormone b. Growth Hormone c. Epinephrine d. Thyroxine
Maryam
c.epinephrine
Divya
Which of the following is NOT a characteristic feature of alveoli in the lung? a. Poor blood supply b. A large surface area c. Thin walls d. Chemical layer called surfactant
Maryam
a.poor blood supply
Divya
poor blood supply
Tanvi
Excess of cortisol causes______________? a. Acromegaly b. Conn’s syndrome c. Diabetes insipidus d. Cushing syndrome
Maryam
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Maryam
cushing syndrome
Tanvi
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Maryam
Airway resistance in the human lung is? a. Greatest in the generation of distal bronchioles in healthy people because these airways have the smallest radii b. Not increased during a forced expiration in a healthy subject c. Decreased when breathing through the mouth d. Inversely proportional
Maryam
what happens to the brain when one cannot sleep
aghedo
it means melatonin is not released enough to make u fall asleep or there is a disturbance or destruction for melatonin to be released on time
Mhoses

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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