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How bones grow in length

The epiphyseal plate is the area of growth in a long bone. It is a layer of hyaline cartilage where ossification occurs in immature bones. On the epiphyseal side of the epiphyseal plate, cartilage is formed. On the diaphyseal side, cartilage is ossified, and the diaphysis grows in length. The epiphyseal plate is composed of four zones of cells and activity ( [link] ). The reserve zone    is the region closest to the epiphyseal end of the plate and contains small chondrocytes within the matrix. These chondrocytes do not participate in bone growth but secure the epiphyseal plate to the osseous tissue of the epiphysis.

Longitudinal bone growth

This illustration shows the zones bordering the epiphyseal plate of the epiphysis. The topmost layer of the epiphysis is the reserve zone, which is colored blue because it is made of cartilage. Two arteries are shown travelling through this zone to supply nutrients to the second zone: the proliferative zone. Here, five chondrocytes are undergoing mitosis. They continually divide, producing five long rows of chondrocytes. The next zone is the zone of maturation and hypertrophy. Here, lipids, glycogen and alkaline phosphatase accumulate, causing the cartilaginous matrix to calcify. This zone consists of five rows of ten chondrocytes which are increasing in size as one moves down a row. The next zone is the calcified matrix. Here, the chondrocytes have hardened and die as the matrix around them has calcified. The bottommost row is the zone of ossification. This zone is actually part of the metaphysis. Arteries from the metaphysis branch through the newly-formed trabeculae in this zone. The newly deposited bone tissue at the top of the zone of ossification is called the primary spongiosa. The older bone at the bottom of the zone of ossification is labeled the secondary spongiosa.
The epiphyseal plate is responsible for longitudinal bone growth.

The proliferative zone    is the next layer toward the diaphysis and contains stacks of slightly larger chondrocytes. It makes new chondrocytes (via mitosis) to replace those that die at the diaphyseal end of the plate. Chondrocytes in the next layer, the zone of maturation and hypertrophy    , are older and larger than those in the proliferative zone. The more mature cells are situated closer to the diaphyseal end of the plate. The longitudinal growth of bone is a result of cellular division in the proliferative zone and the maturation of cells in the zone of maturation and hypertrophy.

Most of the chondrocytes in the zone of calcified matrix    , the zone closest to the diaphysis, are dead because the matrix around them has calcified. Capillaries and osteoblasts from the diaphysis penetrate this zone, and the osteoblasts secrete bone tissue on the remaining calcified cartilage. Thus, the zone of calcified matrix connects the epiphyseal plate to the diaphysis. A bone grows in length when osseous tissue is added to the diaphysis.

Bones continue to grow in length until early adulthood. The rate of growth is controlled by hormones, which will be discussed later. When the chondrocytes in the epiphyseal plate cease their proliferation and bone replaces the cartilage, longitudinal growth stops. All that remains of the epiphyseal plate is the epiphyseal line    ( [link] ).

Progression from epiphyseal plate to epiphyseal line

This illustration shows anterior views of a right and left femur. The left femur possesses a growth plate at the border of its distal metaphysis and distal epiphysis. The proximal epiphysis has two growth plates. The first is located below the head of the femur while the second is located below the trochanter, which is the bump on the lateral side of the femur. The right femur has the same plates as the left femur. However, the left femur represents a mature long bone. Here, growth is completed and the epiphyseal plate has degraded to a thin, faint, epiphyseal line.
As a bone matures, the epiphyseal plate progresses to an epiphyseal line. (a) Epiphyseal plates are visible in a growing bone. (b) Epiphyseal lines are the remnants of epiphyseal plates in a mature bone.

How bones grow in diameter

While bones are increasing in length, they are also increasing in diameter; growth in diameter can continue even after longitudinal growth ceases. This is called appositional growth. Osteoclasts resorb old bone that lines the medullary cavity, while osteoblasts, via intramembranous ossification, produce new bone tissue beneath the periosteum. The erosion of old bone along the medullary cavity and the deposition of new bone beneath the periosteum not only increase the diameter of the diaphysis but also increase the diameter of the medullary cavity. This process is called modeling    .

Bone remodeling

The process in which matrix is resorbed on one surface of a bone and deposited on another is known as bone modeling. Modeling primarily takes place during a bone’s growth. However, in adult life, bone undergoes remodeling    , in which resorption of old or damaged bone takes place on the same surface where osteoblasts lay new bone to replace that which is resorbed. Injury, exercise, and other activities lead to remodeling. Those influences are discussed later in the chapter, but even without injury or exercise, about 5 to 10 percent of the skeleton is remodeled annually just by destroying old bone and renewing it with fresh bone.

Diseases of the…

Skeletal system

Osteogenesis imperfecta (OI) is a genetic disease in which bones do not form properly and therefore are fragile and break easily. It is also called brittle bone disease. The disease is present from birth and affects a person throughout life.

The genetic mutation that causes OI affects the body’s production of collagen, one of the critical components of bone matrix. The severity of the disease can range from mild to severe. Those with the most severe forms of the disease sustain many more fractures than those with a mild form. Frequent and multiple fractures typically lead to bone deformities and short stature. Bowing of the long bones and curvature of the spine are also common in people afflicted with OI. Curvature of the spine makes breathing difficult because the lungs are compressed.

Because collagen is such an important structural protein in many parts of the body, people with OI may also experience fragile skin, weak muscles, loose joints, easy bruising, frequent nosebleeds, brittle teeth, blue sclera, and hearing loss. There is no known cure for OI. Treatment focuses on helping the person retain as much independence as possible while minimizing fractures and maximizing mobility. Toward that end, safe exercises, like swimming, in which the body is less likely to experience collisions or compressive forces, are recommended. Braces to support legs, ankles, knees, and wrists are used as needed. Canes, walkers, or wheelchairs can also help compensate for weaknesses.

When bones do break, casts, splints, or wraps are used. In some cases, metal rods may be surgically implanted into the long bones of the arms and legs. Research is currently being conducted on using bisphosphonates to treat OI. Smoking and being overweight are especially risky in people with OI, since smoking is known to weaken bones, and extra body weight puts additional stress on the bones.

Watch this video to see how a bone grows.

Chapter review

All bone formation is a replacement process. Embryos develop a cartilaginous skeleton and various membranes. During development, these are replaced by bone during the ossification process. In intramembranous ossification, bone develops directly from sheets of mesenchymal connective tissue. In endochondral ossification, bone develops by replacing hyaline cartilage. Activity in the epiphyseal plate enables bones to grow in length. Modeling allows bones to grow in diameter. Remodeling occurs as bone is resorbed and replaced by new bone. Osteogenesis imperfecta is a genetic disease in which collagen production is altered, resulting in fragile, brittle bones.

Questions & Answers

structure of a serous membrane
Ziyanda Reply
are you asking?
Isa
Name the two phases of metabolism
Grace Reply
reproduction and growth
Zozo
how about anabolism and catabolism?
Japhar
In Simply Anabolism means formation... Catabolism means breakdown
Jazil
two phases of reproductio?
Japhar
Anabolism indicates potential & catabolism potential converts to kinetic
Doctor
Name the most important life process in the human body in terms of anatomy and physiology
Grace
Nervous system
Nimco
Every system is important for body functions
Jazil
what is the difference between the functions of the adhesion belt and the desmosomes?
Mason Reply
what are the derivatives of the germ layer?
Miriam Reply
zygote
Zozo
Pls explain the atlas of the cervical vertebral column
Ifunanya Reply
why does the material not allow in mri
Simran Reply
what do you mean 'mri'
Nimco
short for magnetic resonance imaging. "the researchers used MRI to record the brain activity" a medical examination performed using magnetic resonance imaging. "he's having an MRI to determine the extent of the injury" an image obtained by magnetic resonance imaging. "after looking at the MRI, the d
Riyaz
what is the meaning of sutures
Ibrahim Reply
i do not know
Nimo
immovable joints btn two bones.eg the skull bones
Japhar
Really,it's true
Nimco
Sutures are immovable junction between two bones e.g those of the skull
Surphy
what should I do to get or to know what to do for me to be excellent in the course of anatomy and physiology
Sandra Reply
study harder
Japhar
Between the heart and the Brain which one is more important to human being... discuss
Faith Reply
well the brain is important for motor skills, the heart is important for involuntary muscle movement supporting body functions. the body can survive without brain involvement, but the body cannot last without the heart
john
granted the heart is important, but the brain gives the body purpose
john
the brain is more important
Kevin
why?
john
brain
tracey
Even though the brain helps the human being to behave normally and purposefully, I think the heart is much more important cos human being cannot live without the heart
Dzifa
why?
john
change the question
Bind
hello guys
Kevin
heart
Kevin
it is difficult to select which organ is more important, now you can replace the heart with a mechanical device and the body could still function, and with technology today brain activity can also be replicated. But life would not be the same
john
there's coordination btn the two..so without any of them no life
Japhar
the heart
The brain is important to humans.
Zozo
what is homeostasis
Rebecca Reply
It is the condition when body feel comfortable
Jazil
Wo feels hungry, thirty due to homeostasis
Jazil
Is the maintenance of the internal environment of all the body cells for normal growth
Komolika
what is the composition of saliva
Vijay Reply
ഫസ്റ്റ് ചാപ്റ്റർ ഇംപോർട്ടൻസ് പോസ്റ്റ്
Reshma Reply
Yes....
Loving
nhi samjh aya
Anshika
Nhi wt is this
Loving
I don't know
Anshika
Okk wre frm u r
Loving
what is mean of? reshma
Asad
I don't know but would like to
Rebecca
D bone in d ankle joint re what ?
Ifunanya Reply
patellar
Ibrahim
I thought that patella us the bone found in the knee cap
Ifunanya
fib and tib join with tarsal form ankle joint
Ava
Thanks
Ifunanya
can one define a cell as a basic unit of a living organism
Michael Reply
cell is the structural and functional unit of living organisms
Fidel
Which of the following hormones are responsible for the adolescent growth spurt? estrogen and testosterone, even in women?
Kepa Reply
estrogen
Farhana
Estrogen!
Jazil
estrogen hormone
Michael
yes estrogen hormone
Anshika
yes
Sale
testrogen
Rebecca

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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