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If a chemical reaction absorbs energy rather than releases energy on balance, then the ∆G for that reaction will be a positive value. In this case, the products have more free energy than the reactants. Thus, the products of these reactions can be thought of as energy-storing molecules. These chemical reactions are called endergonic reactions and they are non-spontaneous. An endergonic reaction will not take place on its own without the addition of free energy.

Art connection

Four photos, from left to right, show a compost pile, a baby chick emerging from a fertilized egg, a teabag’s dark-colored contents diffusing into a clear mug of water, and a ball rolling downhill.
Shown are some examples of endergonic processes (ones that require energy) and exergonic processes (ones that release energy). (credit a: modification of work by Natalie Maynor; credit b: modification of work by USDA; credit c: modification of work by Cory Zanker; credit d: modification of work by Harry Malsch)

Look at each of the processes shown and decide if it is endergonic or exergonic.

There is another important concept that must be considered regarding endergonic and exergonic reactions. Exergonic reactions require a small amount of energy input to get going, before they can proceed with their energy-releasing steps. These reactions have a net release of energy, but still require some energy input in the beginning. This small amount of energy input necessary for all chemical reactions to occur is called the activation energy    .

Concept in action

Watch an animation of the move from free energy to transition state of the reaction.


A substance that helps a chemical reaction to occur is called a catalyst, and the molecules that catalyze biochemical reactions are called enzymes . Most enzymes are proteins and perform the critical task of lowering the activation energies of chemical reactions inside the cell. Most of the reactions critical to a living cell happen too slowly at normal temperatures to be of any use to the cell. Without enzymes to speed up these reactions, life could not persist. Enzymes do this by binding to the reactant molecules and holding them in such a way as to make the chemical bond-breaking and -forming processes take place more easily. It is important to remember that enzymes do not change whether a reaction is exergonic (spontaneous) or endergonic. This is because they do not change the free energy of the reactants or products. They only reduce the activation energy required for the reaction to go forward ( [link] ). In addition, an enzyme itself is unchanged by the reaction it catalyzes. Once one reaction has been catalyzed, the enzyme is able to participate in other reactions.

This plot shows that a catalyst decreases the activation energy for a reaction but does not change the Gibbs free energy.
Enzymes lower the activation energy of the reaction but do not change the free energy of the reaction.

The chemical reactants to which an enzyme binds are called the enzyme’s substrates . There may be one or more substrates, depending on the particular chemical reaction. In some reactions, a single reactant substrate is broken down into multiple products. In others, two substrates may come together to create one larger molecule. Two reactants might also enter a reaction and both become modified, but they leave the reaction as two products. The location within the enzyme where the substrate binds is called the enzyme’s active site    . The active site is where the “action” happens. Since enzymes are proteins, there is a unique combination of amino acid side chains within the active site. Each side chain is characterized by different properties. They can be large or small, weakly acidic or basic, hydrophilic or hydrophobic, positively or negatively charged, or neutral. The unique combination of side chains creates a very specific chemical environment within the active site. This specific environment is suited to bind to one specific chemical substrate (or substrates).

Questions & Answers

Cellular respiration
Lucy Reply
what are the characteristics of living things
Ruth Reply
Movement Respiration Nutrition/Feeding Irritability/Sensitivity Growth Excretion Reproduction Deat/Life span
What makes children from the same father and mother sometimes don't look alike?
identification of problems
Nana Reply
what happens in the process of raising the human arms
what is biology
Brandi Reply
first step in scientific method
In an investigation the pancreatic duct of a mammal was blocked.It was found that the blood sugar regulation remained normal while food digestion was impaired.Explain
Mac Reply
To begin with, obstruction of pancreatic duct will alter the blood sugar level as the juices responsible for glucose regulation will be rendered inconsequential. This will in turn affect the rate of digestion and absorbtion of digested food substances by the Villus .
characteristics of algae
Algae are eukaryotic organisms. Algae do not have roots and stems. Algae have chlorophyll and helps in carrying out photosynthesis.
Cell wall is the rigid layer enclosed by membranes of plants and prokayortic cell, it maintains the shape of the cell and serve as a protective barrier.
chizoba Reply
ECOLOGY: is a branch of biology that studies the interactions among organisms and their biophysical environment, which includes both biotic and abiotic components. 
via nutrient cycles and energy flows. For instance, the energy from the sun is captured by plants through photosynthesis. Photosynthesis is a biological process through which plants manufacture their own food with the aid of light from the sun and frc sources (e.g. cabon dioxide and water)
What is cell wall
Taiwo Reply
cell wall is the outemost rigid covering of the plants ,that provides protection to the plants.
what is ecology, ecosystem?
Nkeng Reply
what is digestive system
Lucky Reply
digestive system is the human syman system that icludes esopuges stomach o braking down of food in to useful substance to our body
definition of biology basics
Ritu Reply
the potential energy of a molecule can be inquired by their number of?
Jesus Reply
what is the full meaning of RNA
Ayo Reply
ribose nucleic acid
Ribonucleic acid
Ribo Nucleic Acid
ribonucleic acid
discuss, describe at least three (3) methods that could be used to improve photosynthesis..
Marvel Reply
Improve the efficiency with which plants capture light Improve the efficiency by which plants turn light into energy The smart canopy concept develop crop planting schemes that increase the penetration of sunlight into lower-level leaves.
what is osmosis
Aon Reply
movement of water molecule from higher to lower concentration through a semipereable membrene.
what of in the case of solute
osmosis is the movement of molecules from higher concentration region to lower concentration region through semi-permeable membrane.
in case of solute means that water moves from the region with lower solutes to the region with higher solute. so it is vice versa to water.
osmosis is the movement of water molecule from a region of lower concentration to a region of higher concentration through a semi permeable membrane

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Source:  OpenStax, Concepts of biology. OpenStax CNX. Feb 29, 2016 Download for free at http://cnx.org/content/col11487/1.9
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