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By the end of this section, you will be able to:
  • Describe prions and their basic properties
  • Define viroids and their targets of infection

Prions and viroids are pathogens (agents with the ability to cause disease) that have simpler structures than viruses but, in the case of prions, still can produce deadly diseases.

Prions

Prions , so-called because they are proteinaceous, are infectious particles—smaller than viruses—that contain no nucleic acids (neither DNA nor RNA). Historically, the idea of an infectious agent that did not use nucleic acids was considered impossible, but pioneering work by Nobel Prize-winning biologist Stanley Prusiner has convinced the majority of biologists that such agents do indeed exist.

Fatal neurodegenerative diseases, such as kuru in humans and bovine spongiform encephalopathy (BSE) in cattle (commonly known as “mad cow disease”) were shown to be transmitted by prions. The disease was spread by the consumption of meat, nervous tissue, or internal organs between members of the same species. Kuru, native to humans in Papua New Guinea, was spread from human to human via ritualistic cannibalism. BSE, originally detected in the United Kingdom, was spread between cattle by the practice of including cattle nervous tissue in feed for other cattle. Individuals with kuru and BSE show symptoms of loss of motor control and unusual behaviors, such as uncontrolled bursts of laughter with kuru, followed by death. Kuru was controlled by inducing the population to abandon its ritualistic cannibalism.

On the other hand, BSE was initially thought to only affect cattle. Cattle dying of the disease were shown to have developed lesions or “holes” in the brain, causing the brain tissue to resemble a sponge. Later on in the outbreak, however, it was shown that a similar encephalopathy in humans known as variant Creutzfeldt-Jakob disease (CJD) could be acquired from eating beef from animals with BSE, sparking bans by various countries on the importation of British beef and causing considerable economic damage to the British beef industry ( [link] ). BSE still exists in various areas, and although a rare disease, individuals that acquire CJD are difficult to treat. The disease can be spread from human to human by blood, so many countries have banned blood donation from regions associated with BSE.

The cause of spongiform encephalopathies, such as kuru and BSE, is an infectious structural variant of a normal cellular protein called PrP (prion protein). It is this variant that constitutes the prion particle. PrP exists in two forms, PrP c    , the normal form of the protein, and PrP sc    , the infectious form. Once introduced into the body, the PrP sc contained within the prion binds to PrP c and converts it to PrP sc . This leads to an exponential increase of the PrP sc protein, which aggregates. PrP sc is folded abnormally, and the resulting conformation (shape) is directly responsible for the lesions seen in the brains of infected cattle. Thus, although not without some detractors among scientists, the prion seems likely to be an entirely new form of infectious agent, the first one found whose transmission is not reliant upon genes made of DNA or RNA.

Part a illustrates how normal prion protein (PRP) is converted into the disease-causing form (PRP). PRPsc may spontaneously form in brain tissue, may be introduced when a mutant form of the protein misfolds, or may introduced into the brain tissue by inoculation. The misfolded protein causes normal PRP already present in the brain to misfold. A chain reaction occurs, leading to a large amount of misfolded protein.
(a) Endogenous normal prion protein (PrP c ) is converted into the disease-causing form (PrP sc ) when it encounters this variant form of the protein. PrP sc may arise spontaneously in brain tissue, especially if a mutant form of the protein is present, or it may occur via the spread of misfolded prions consumed in food into brain tissue. (b) This prion-infected brain tissue, visualized using light microscopy, shows the vacuoles that give it a spongy texture, typical of transmissible spongiform encephalopathies. (credit b: modification of work by Dr. Al Jenny, USDA APHIS; scale-bar data from Matt Russell)

Viroids

Viroids are plant pathogens: small, single-stranded, circular RNA particles that are much simpler than a virus. They do not have a capsid or outer envelope, but like viruses can reproduce only within a host cell. Viroids do not, however, manufacture any proteins, and they only produce a single, specific RNA molecule. Human diseases caused by viroids have yet to be identified.

Viroids are known to infect plants ( [link] ) and are responsible for crop failures and the loss of millions of dollars in agricultural revenue each year. Some of the plants they infect include potatoes, cucumbers, tomatoes, chrysanthemums, avocados, and coconut palms.

The photo shows shriveled, cracked potatoes.
These potatoes have been infected by the potato spindle tuber viroid (PSTV), which is typically spread when infected knives are used to cut healthy potatoes, which are then planted. (credit: Pamela Roberts, University of Florida Institute of Food and Agricultural Sciences, USDA ARS)

Career connection

Virologist

Virology is the study of viruses, and a virologist is an individual trained in this discipline. Training in virology can lead to many different career paths. Virologists are actively involved in academic research and teaching in colleges and medical schools. Some virologists treat patients or are involved in the generation and production of vaccines. They might participate in epidemiologic studies ( [link] ) or become science writers, to name just a few possible careers.

This photo shows a scientist in a field, measuring the length of an egg.
This virologist is engaged in fieldwork, sampling eggs from this nest for avian influenza. (credit: Don Becker, USGS EROS, U.S. Fish and Wildlife Service)

If you think you may be interested in a career in virology, find a mentor in the field. Many large medical centers have departments of virology, and smaller hospitals usually have virology labs within their microbiology departments. Volunteer in a virology lab for a semester or work in one over the summer. Discussing the profession and getting a first-hand look at the work will help you decide whether a career in virology is right for you. The American Society of Virology’s website is a good resource for information regarding training and careers in virology.

Section summary

Prions are infectious agents that consist of protein, but no DNA or RNA, and seem to produce their deadly effects by duplicating their shapes and accumulating in tissues. They are thought to contribute to several progressive brain disorders, including mad cow disease and Creutzfeldt-Jakob disease. Viroids are single-stranded RNA pathogens that infect plants. Their presence can have a severe impact on the agriculture industry.

Questions & Answers

guy I need the answer of this question what occurs during photosynthesis
REAL Reply
Photosynthesis is the process that plants use to convert light into food. During this process, plants create carbohydrates starting with only carbon dioxide and water. Sunlight provides the energy that makes photosynthesis possible.
Stanley
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Evans
what are different between genotype and phenotype
Martha Reply
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Martha
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Martha
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Martha
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Martha
what is ecology
Adeyemo Reply
what is zoology
Adeyemo
zoology branch of biology that study animals
Moses
a branch of biology which deals with the study of animals
Anita
A plant is a living thing that grows in the earth and has a stem, leaves, and roots
Bello Reply
what is a plant
dalitso Reply
A plant is a living thing that grows in the earth and has a stem, leaves, and roots
Bello
a plant is an is a living thing that is classified under autothrops because it makes its own food through the process of photosynthesis .
Joanne
a plant is also known as autotropic category and a plant have root & stem
Anita
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Odion Reply
Plants are autotrophic
Baramox
Then animal are heterotrophic
Iyiola
what are organisms
Godfred Reply
Living structures
Aryavarta
living and non living which charectrised by different properties
Anita
organisms living and nonliving components of the environment with distinct xtics
Tony
the diagram below show how the blood of a human embryo flows close to the mothers blood in the placenta . which substances are represent at x in higher concentrations than at y
Joyce Reply
what is ecology
Odion Reply
what is cell
Odion
what is cell
Odion
Is the basic unit of life
Agatha
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Okebe
biology is the study of life
Ali
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Okebe
What are enzymes?
Zanga
if you want to know more, please start studying biology from the beginning systematically
Best
enzymes are biological catalyst that speed up d rate biochemical reactions
Ning
What is a cell
Awal Reply
What are tissues
Awal
A cell is the smallest unit of living organisms.
hamidat
Tissues are group of similar cells performing a particular function.
hamidat
how to pronounce the word cyanobacteria
siva Reply
Cyano then bacteria. look that "cyano" is just like "ciyano".
hamidat
explain the term transpiration pull
Tank Reply
water is mainly " pulled" through the plant and that the driving force for this process is transpiration from the leaves .This is also referred to as the cohesion- tension -transpiration pull model transport.
Vanessa
explain TRANSIOCATION and GUTATION
Tank
what's chemistry
Okebe
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hamidat
Google it for the right answer. Corona is a virus which causes Novel Covid-19 disease that has been declared by WHO as a global or world pandemic.
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Katlholo
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Odion
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Odion
condinative system is the system that harmonize all the. different. part. of. the. body and make. them function as a. specific unit
Odion
Describe the process of protein sythesis?
Kizito Reply
Ribosomes are responsible for protein synthesis in animals.
hamidat
What is a ploidy level
Francis Reply
Ploidy refers to the number of chromosomes. We have 23 pairs of chromosomes in somatic cells. Sex cells are haploid thus 23 chromosomes vs. 46 Chromosomes.
Eric
Evolution is evolvement according to one's environment. Let's use humidity as an example. A person from a very cold environment would not be used to hot humid weather. But over time their body would slowly, slowly adapt.
Eric
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Jay
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INGIEBE
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Source:  OpenStax, Biology. OpenStax CNX. Feb 29, 2016 Download for free at http://cnx.org/content/col11448/1.10
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