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The formation of a peptide bond between two amino acids is shown. When the peptide bond forms, the carbon from the carbonyl group becomes attached to the nitrogen from the amino group. The OH from the carboxyl group and an H from the amino group form a molecule of water.
Peptide bond formation is a dehydration synthesis reaction. The carboxyl group of one amino acid is linked to the amino group of the incoming amino acid. In the process, a molecule of water is released.

The products formed by such linkages are called peptides. As more amino acids join to this growing chain, the resulting chain is known as a polypeptide. Each polypeptide has a free amino group at one end. This end is called the N terminal, or the amino terminal, and the other end has a free carboxyl group, also known as the C or carboxyl terminal. While the terms polypeptide and protein are sometimes used interchangeably, a polypeptide is technically a polymer of amino acids, whereas the term protein is used for a polypeptide or polypeptides that have combined together, often have bound non-peptide prosthetic groups, have a distinct shape, and have a unique function. After protein synthesis (translation), most proteins are modified. These are known as post-translational modifications. They may undergo cleavage, phosphorylation, or may require the addition of other chemical groups. Only after these modifications is the protein completely functional.

Click through the steps of protein synthesis in this interactive tutorial .

Evolution connection

The evolutionary significance of cytochrome c

Cytochrome c is an important component of the electron transport chain, a part of cellular respiration, and it is normally found in the cellular organelle, the mitochondrion. This protein has a heme prosthetic group, and the central ion of the heme gets alternately reduced and oxidized during electron transfer. Because this essential protein’s role in producing cellular energy is crucial, it has changed very little over millions of years. Protein sequencing has shown that there is a considerable amount of cytochrome c amino acid sequence homology among different species; in other words, evolutionary kinship can be assessed by measuring the similarities or differences among various species’ DNA or protein sequences.

Scientists have determined that human cytochrome c contains 104 amino acids. For each cytochrome c molecule from different organisms that has been sequenced to date, 37 of these amino acids appear in the same position in all samples of cytochrome c. This indicates that there may have been a common ancestor. On comparing the human and chimpanzee protein sequences, no sequence difference was found. When human and rhesus monkey sequences were compared, the single difference found was in one amino acid. In another comparison, human to yeast sequencing shows a difference in the 44th position.

Protein structure

As discussed earlier, the shape of a protein is critical to its function. For example, an enzyme can bind to a specific substrate at a site known as the active site. If this active site is altered because of local changes or changes in overall protein structure, the enzyme may be unable to bind to the substrate. To understand how the protein gets its final shape or conformation, we need to understand the four levels of protein structure: primary, secondary, tertiary, and quaternary.

Questions & Answers

A plant is a living thing that grows in the earth and has a stem, leaves, and roots
Bello Reply
what is a plant
dalitso Reply
A plant is a living thing that grows in the earth and has a stem, leaves, and roots
Bello
a plant is an is a living thing that is classified under autothrops because it makes its own food through the process of photosynthesis .
Joanne
what is plant
Odion Reply
Plants are autotrophic
Baramox
Then animal are heterotrophic
Iyiola
what are organisms
Godfred Reply
the diagram below show how the blood of a human embryo flows close to the mothers blood in the placenta . which substances are represent at x in higher concentrations than at y
Joyce Reply
what is ecology
Odion Reply
what is cell
Odion
what is cell
Odion
What is a cell
Awal Reply
What are tissues
Awal
A cell is the smallest unit of living organisms.
hamidat
Tissues are group of similar cells performing a particular function.
hamidat
how to pronounce the word cyanobacteria
siva Reply
Cyano then bacteria. look that "cyano" is just like "ciyano".
hamidat
explain the term transpiration pull
Tank Reply
water is mainly " pulled" through the plant and that the driving force for this process is transpiration from the leaves .This is also referred to as the cohesion- tension -transpiration pull model transport.
Vanessa
explain TRANSIOCATION and GUTATION
Tank
what Is corona
INGIEBE Reply
My brother go and ask GOOGLE😷😷😷
hamidat
Google it for the right answer. Corona is a virus which causes Novel Covid-19 disease that has been declared by WHO as a global or world pandemic.
Katlholo
Why is it called Covid-19?
Katlholo
jjwhat is. condinative system
Odion
joy
Odion
condinative system is the system that harmonize all the. different. part. of. the. body and make. them function as a. specific unit
Odion
Describe the process of protein sythesis?
Kizito Reply
Ribosomes are responsible for protein synthesis in animals.
hamidat
What is a ploidy level
Francis Reply
Ploidy refers to the number of chromosomes. We have 23 pairs of chromosomes in somatic cells. Sex cells are haploid thus 23 chromosomes vs. 46 Chromosomes.
Eric
Evolution is evolvement according to one's environment. Let's use humidity as an example. A person from a very cold environment would not be used to hot humid weather. But over time their body would slowly, slowly adapt.
Eric
Give me (3) types of biodiversity
Jay
Hi guys 🇧🇪
Namutebi
hello boy
Tedi
hi
INGIEBE
yes
amani
what do you guys understand about evolution?
Kiana Reply
it's a process or analayzing some program
Fahamia
but am not sure if some know plz let share
Fahamia
is a study of
Sarah
unfolding or unrolling hence the process of development of growth
Sarah
is the periodic change of the structural features of an organism
Rahim
I think
Rahim
process of developing
Nikita
hi guiz
Mohammed
hello guys
Safuna
hi
Kaniki
Evolution ~ Is the gradual change of development over time in which a new species are formed
amani
Evolution is the sum total of adaptive changes that has existed before.
hamidat
odionjimoh
Odion
hi
Odion
why are diagrams not available
Evans Reply
How can nucleotide molecules of DNA be constructed?construct a six molecules of DNA?
Julia Reply
You take a Deoxyribose sugar. The Deoxyribose sugar has a hydrogen on the second carbon vs. an OH group. The nitrogenous base binds to the #1 Carbon and a phosphate binds to the 5'. When the 2nd NBase bonds, it does so on the 3' Carbon. Thus you have 5' to 3' directional growth.
Eric
what is the explanation of local biomes in Nigeria
Kabir
It would be savanna, tropical grassland.
Eric

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Source:  OpenStax, Biology. OpenStax CNX. Feb 29, 2016 Download for free at http://cnx.org/content/col11448/1.10
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