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Biotechnology in medicine and agriculture

It is easy to see how biotechnology can be used for medicinal purposes. Knowledge of the genetic makeup of our species, the genetic basis of heritable diseases, and the invention of technology to manipulate and fix mutant genes provides methods to treat the disease. Biotechnology in agriculture can enhance resistance to disease, pest, and environmental stress, and improve both crop yield and quality.

Genetic diagnosis and gene therapy

The process of testing for suspected genetic defects before administering treatment is called genetic diagnosis    by genetic testing    . Depending on the inheritance patterns of a disease-causing gene, family members are advised to undergo genetic testing. For example, women diagnosed with breast cancer are usually advised to have a biopsy so that the medical team can determine the genetic basis of cancer development. Treatment plans are based on the findings of genetic tests that determine the type of cancer. If the cancer is caused by inherited gene mutations, other female relatives are also advised to undergo genetic testing and periodic screening for breast cancer. Genetic testing is also offered for fetuses (or embryos with in vitro fertilization) to determine the presence or absence of disease-causing genes in families with specific debilitating diseases.

Gene therapy is a genetic engineering technique used to cure disease. In its simplest form, it involves the introduction of a good gene at a random location in the genome to aid the cure of a disease that is caused by a mutated gene. The good gene is usually introduced into diseased cells as part of a vector transmitted by a virus that can infect the host cell and deliver the foreign DNA ( [link] ). More advanced forms of gene therapy try to correct the mutation at the original site in the genome, such as is the case with treatment of severe combined immunodeficiency (SCID).

To cure disease using an adenovirus vector, a new gene intended to replace a defective one is packaged with the adenovirus genome. The genes that make the virus pathogenic are removed. The modified DNA is put inside the virus’ capsid, or protein coat. The person to be cured is infected with the modified virus. Viral DNA enters the nucleus, where the modified gene can replace the defective one.
Gene therapy using an adenovirus vector can be used to cure certain genetic diseases in which a person has a defective gene. (credit: NIH)

Production of vaccines, antibiotics, and hormones

Traditional vaccination strategies use weakened or inactive forms of microorganisms to mount the initial immune response. Modern techniques use the genes of microorganisms cloned into vectors to mass produce the desired antigen. The antigen is then introduced into the body to stimulate the primary immune response and trigger immune memory. Genes cloned from the influenza virus have been used to combat the constantly changing strains of this virus.

Antibiotics are a biotechnological product. They are naturally produced by microorganisms, such as fungi, to attain an advantage over bacterial populations. Antibiotics are produced on a large scale by cultivating and manipulating fungal cells.

Recombinant DNA technology was used to produce large-scale quantities of human insulin in E. coli as early as 1978. Previously, it was only possible to treat diabetes with pig insulin, which caused allergic reactions in humans because of differences in the gene product. In addition, human growth hormone (HGH) is used to treat growth disorders in children. The HGH gene was cloned from a cDNA library and inserted into E. coli cells by cloning it into a bacterial vector.

Questions & Answers

does human being sperm performed in the ovary of goat
sadeeq Reply
levels of ecological study
sadeeq
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Sweety Reply
Georges Lemaître
Mr
the meaning of nucleus
Spring Reply
nucleus Is also known as the cell's headquarters
Feranmi
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Azi Reply
is the study of diseases, it's cause and development of a disease
Boadi
State the law of segregation
Theolla Reply
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Bunmi Reply
A cell is a basic structural unit of an organism
Addo
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Veronica
molecule:a group of atoms bonded together, representing the smallest fundamental unit of a chemical compound that can take part in a chemical reaction.
Black
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Oluebube Reply
Microbiology Biochemistry Botany Zoology Horticulture
Odion
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what is meiosis?
Musa
genetics is the the study of heredity and the variation of inherited characteristics.
Black
meiosis :a type of cell division that results in four daughter cells each with half the number of chromosomes of the parent cell, as in the production of gametes and plant spores.
Black
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lizard, goat, frog ,earthworm, housefly, tapeworm
idoko
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Boadi
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mark Reply
this is the combination of two or more monosacharide
bernard
long chain of monosacchrides joined together by glycosidic bonds
Pepper
water as a function in cell for inorganic substances
chisom Reply
hi john....wat about for mineral salts, its function in a cell and structure
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A1
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Source:  OpenStax, Biology. OpenStax CNX. Feb 29, 2016 Download for free at http://cnx.org/content/col11448/1.10
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