<< Chapter < Page Chapter >> Page >

Blood calcium levels are regulated by parathyroid hormone (PTH)    , which is produced by the parathyroid glands, as illustrated in [link] . PTH is released in response to low blood Ca 2+ levels. PTH increases Ca 2+ levels by targeting the skeleton, the kidneys, and the intestine. In the skeleton, PTH stimulates osteoclasts, which causes bone to be reabsorbed, releasing Ca 2+ from bone into the blood. PTH also inhibits osteoblasts, reducing Ca 2+ deposition in bone. In the intestines, PTH increases dietary Ca 2+ absorption, and in the kidneys, PTH stimulates reabsorption of the CA 2+ . While PTH acts directly on the kidneys to increase Ca 2+ reabsorption, its effects on the intestine are indirect. PTH triggers the formation of calcitriol, an active form of vitamin D, which acts on the intestines to increase absorption of dietary calcium. PTH release is inhibited by rising blood calcium levels.

The parathyroid glands, which are located in the neck, release parathyroid hormone, or PTH. PTH causes the release of calcium from bone and triggers the reabsorption of calcium from the urine in the kidneys. PTH also triggers the formation of calcitriol from vitamin D. Calcitriol causes the intestines to absorb more calcium. The result is increased calcium in the blood.
Parathyroid hormone (PTH) is released in response to low blood calcium levels. It increases blood calcium levels by targeting the skeleton, the kidneys, and the intestine. (credit: modification of work by Mikael Häggström)

Hyperparathyroidism results from an overproduction of parathyroid hormone. This results in excessive calcium being removed from bones and introduced into blood circulation, producing structural weakness of the bones, which can lead to deformation and fractures, plus nervous system impairment due to high blood calcium levels. Hypoparathyroidism, the underproduction of PTH, results in extremely low levels of blood calcium, which causes impaired muscle function and may result in tetany (severe sustained muscle contraction).

The hormone calcitonin    , which is produced by the parafollicular or C cells of the thyroid, has the opposite effect on blood calcium levels as does PTH. Calcitonin decreases blood calcium levels by inhibiting osteoclasts, stimulating osteoblasts, and stimulating calcium excretion by the kidneys. This results in calcium being added to the bones to promote structural integrity. Calcitonin is most important in children (when it stimulates bone growth), during pregnancy (when it reduces maternal bone loss), and during prolonged starvation (because it reduces bone mass loss). In healthy nonpregnant, unstarved adults, the role of calcitonin is unclear.

Hormonal regulation of growth

Hormonal regulation is required for the growth and replication of most cells in the body. Growth hormone (GH) , produced by the anterior portion of the pituitary gland, accelerates the rate of protein synthesis, particularly in skeletal muscle and bones. Growth hormone has direct and indirect mechanisms of action. The first direct action of GH is stimulation of triglyceride breakdown (lipolysis) and release into the blood by adipocytes. This results in a switch by most tissues from utilizing glucose as an energy source to utilizing fatty acids. This process is called a glucose-sparing effect    . In another direct mechanism, GH stimulates glycogen breakdown in the liver; the glycogen is then released into the blood as glucose. Blood glucose levels increase as most tissues are utilizing fatty acids instead of glucose for their energy needs. The GH mediated increase in blood glucose levels is called a diabetogenic effect    because it is similar to the high blood glucose levels seen in diabetes mellitus.

Questions & Answers

What is cytoplasm
Nitta Reply
Parasitic adaptation of tapeworm
Angela Reply
Describe osmoregulator or osmoconformers and how these tools allow animals to adapt to different environment.
Alick Reply
describe the secondary function of a leaf to a plant.
Twizera Reply
hi I'm asking a question about HIV infection, can HIV infection transmitted from Mother to unbron child? please help me I So confused.
Khushboy Reply
no it can't
yes it can but their is an injection that can be used to prevent it.
Ahmad how no?
Hi im new
no, unless when giving birth
it is can be transmitted but there is an injection that the mother is injected to prevent the disease
I agree with nia
but I think HIV infection can be transmitted through blood so the unborn baby can be affected by HIV when a slight mistake occurred that what i think
yes, but there is a treatment however, using a retroviral therapy and injection to prevent the unborn child unscathed from the infection
what is the difference between primary and secondary active transport in detail? I didn't understand the steps in the textbook specifically
Fathima Reply
you are a doctor?
what is the meaning of connective tissue?
Mohammed Reply
what are the characteristics of living things
Owolo Reply
what's the meaning of connective tissue?
Reproduction, adaptation, interaction, movement, growth, respiration, made of cells, responsive to environment (homeostasis), metabolic action (consumption of food converted into energy)
Movement, reproduction, nutrition, irritability, growth, excretion, respiration, death, adaptation, competition
state two most important factors that favour exponential growth of population of a gazelle in a pack
Eliza Reply
what are the two types of electron microscope
Sharlom Reply
light microscope and early microscope
Enzymes are biological catalyst which alter any reaction and protein in nature
Nkoue Reply
Your welcome sir
guyz you enjoying
What is translation and transcription
Transcription is making RNA from DNA. Translation is going from RNA to proteins.
full meaning of RNA and DNA
Nkoue what homeostits means?
Mohammed khalfan, In biology, homeostasis is the state of steady internal, physical, and chemical conditions maintained by living systems.[1] This dynamic state of equilibrium is the condition of optimal functioning for the organism and includes many variables, such as body temperature and fluid bal
what is the definition of enzymes
Royd Reply
enzymes are biological catalyst that speed up chemical reaction.
What are enzymes?
Enzymes are made of proteins and lower the energy of activation. In other words, they bring things together which helps to lower the amount of energy for a reaction to go forward.
they are catalyses that speeds up chemical reaction.... e.g they break down the food we consume.
These are catalyst that speeds up the chemical reaction.
What is connective tissue?
what homeostits means ?
what is a spirogyra
Talabi Reply
Spirogyra is a filamentous chlorophyte green algae of the order Zygnematales. It is named for the helical or spiral arrangement of the chloroplasts. That is characteristic of the genus. It is commonly found in freshwater habitats. And there are more than 400 species of Spirogyra in the world.
what is the mean of biology
Bello Reply
what is cell
A cell is the smallest living unit.
Hi I'm new in this group can someone please help with the list features shared by plants and charopytes that are not shared with most other eukaryotes
iz a basic units of a living thing?
what is eutrophication
Chinaza Reply
hi.. I'm asking a question about HIV infection.... Can HIV infection transmitted from Mother to unbron child?
Eutrophication is an enrichment of water by nutrient salts that causes structural changes to the ecosystem such as: increased production of algae and aquatic plants, depletion of fish species, general deterioration of water quality and other effects that reduce and preclude use.

Get the best Biology course in your pocket!

Source:  OpenStax, Biology. OpenStax CNX. Feb 29, 2016 Download for free at http://cnx.org/content/col11448/1.10
Google Play and the Google Play logo are trademarks of Google Inc.

Notification Switch

Would you like to follow the 'Biology' conversation and receive update notifications?