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Illustration shows a T cell receptor, which has two column-like subunits that project from the plasma membrane. The subunits, named alpha and beta, are connected by a disulfide bridge. The upper third of the extracellular portion of each column is called the variable region, and the lower two-thirds is called the constant region. The region that spans the membrane is called the transmembrane region. Beneath the transmembrane region is a short, intracellular region.
A T cell receptor spans the membrane and projects variable binding regions into the extracellular space to bind processed antigens via MHC molecules on APCs.

Helper t lymphocytes

The T H lymphocytes function indirectly to identify potential pathogens for other cells of the immune system. These cells are important for extracellular infections, such as those caused by certain bacteria, helminths, and protozoa. T H lymphocytes recognize specific antigens displayed in the MHC II complexes of APCs. There are two major populations of T H cells: T H 1 and T H 2. T H 1 cells secrete cytokines to enhance the activities of macrophages and other T cells. T H 1 cells activate the action of cyotoxic T cells, as well as macrophages. T H 2 cells stimulate naïve B cells to destroy foreign invaders via antibody secretion. Whether a T H 1 or a T H 2 immune response develops depends on the specific types of cytokines secreted by cells of the innate immune system, which in turn depends on the nature of the invading pathogen.

The T H 1-mediated response involves macrophages and is associated with inflammation. Recall the frontline defenses of macrophages involved in the innate immune response. Some intracellular bacteria, such as Mycobacterium tuberculosis , have evolved to multiply in macrophages after they have been engulfed. These pathogens evade attempts by macrophages to destroy and digest the pathogen. When M. tuberculosis infection occurs, macrophages can stimulate naïve T cells to become T H 1 cells. These stimulated T cells secrete specific cytokines that send feedback to the macrophage to stimulate its digestive capabilities and allow it to destroy the colonizing M. tuberculosis . In the same manner, T H 1-activated macrophages also become better suited to ingest and kill tumor cells. In summary; T H 1 responses are directed toward intracellular invaders while T H 2 responses are aimed at those that are extracellular.

B lymphocytes

When stimulated by the T H 2 pathway, naïve B cells differentiate into antibody-secreting plasma cells. A plasma cell    is an immune cell that secrets antibodies; these cells arise from B cells that were stimulated by antigens. Similar to T cells, naïve B cells initially are coated in thousands of B cell receptors (BCRs), which are membrane-bound forms of Ig (immunoglobulin, or an antibody). The B cell receptor has two heavy chains and two light chains connected by disulfide linkages. Each chain has a constant and a variable region; the latter is involved in antigen binding. Two other membrane proteins, Ig alpha and Ig beta, are involved in signaling. The receptors of any particular B cell, as shown in [link] are all the same, but the hundreds of millions of different B cells in an individual have distinct recognition domains that contribute to extensive diversity in the types of molecular structures to which they can bind. In this state, B cells function as APCs. They bind and engulf foreign antigens via their BCRs and then display processed antigens in the context of MHC II molecules to T H 2 cells. When a T H 2 cell detects that a B cell is bound to a relevant antigen, it secretes specific cytokines that induce the B cell to proliferate rapidly, which makes thousands of identical (clonal) copies of it, and then it synthesizes and secretes antibodies with the same antigen recognition pattern as the BCRs. The activation of B cells corresponding to one specific BCR variant and the dramatic proliferation of that variant is known as clonal selection    . This phenomenon drastically, but briefly, changes the proportions of BCR variants expressed by the immune system, and shifts the balance toward BCRs specific to the infecting pathogen.

Questions & Answers

water as a function in cell for inorganic substances
chisom Reply
hi john....wat about for mineral salts, its function in a cell and structure
chisom
hi chisom which topic is this
Ezeh
this biology is for which grade?
Janet Reply
A1
Boadi
state any one specialized animal cell and it's function
Pascal Reply
sperm cell: Fertilization
Tshering
Can DNA and RNA be praticalized
Oyewale Reply
you can make models of them and show how they replicate
Oswald
what is dentition
Tisa Reply
Study of teeths and their functions
Stanisla
what are the function
Tisa
it's not teeths. teeth is plural as well as singular noun. the function of the teeth is to cut and grind food for easier swallowing and for increasing the surface area if the fish as the substrate in which digestive enzymes work
Oswald
dentition is not the study of teeth but the arrangement of teeth in the mouth of species or individuals
Oswald
what are the two types of teeth
Tisa
Function of probosis
Adeola Reply
why do we study biology?
SYDNEY Reply
where biology began
Alhaji
What are chromesome
Talkmore Reply
condensed DNA wrapped with histone
Elias
chromosomes are gins that we take from our parents.when mom get pregnant the baby inside is made up of 23 chromosomes from his dad and 23 chromosomes from his mom.so a baby is made up of totally 46 chromosomes
ezera
chromosome are rod or thread shape body located in the nucleus of a cell.
Alhaji
what is chromosome?
Royd Reply
How can a person who has been in the vascular disease repairs his or her DNA
Rabson Reply
i need its explanation sir..pls provid na...🙁
Shaf Reply
Of wat
John
explanation for wat
Christian
Of war na so dat I can provide
John
Is d process which food is converted into substance dat can be utilize by d body
John
the meaning of disgestion
Charity Reply
because they are considered to be proteins ..lipids,fats, and nucleic acids
Geeta Reply
what is osmosis
Festus Reply
Is the movement of solvent molecules from the region of a higher concentration to the region of lower concentration
Muhammad
It is the movement of solvent from the region of lower concentration to the region of higher concentration through a semi-permeable membrane.
Helen
and diffusion
Prudent
it is the movement of water molecules fro region of higher conc. to the region of lower conc.thro a semi-permeable membrane.
Chansa
Diffusion is the movement of solute molecules from a region of higher concentration to a region of lower concentration.
Quartey
osmosis is the movement of water molecule from the region higher water potential to a region of lower water potential
Pascal
what is the function of Nerve cell?
Pascal
Hello Everyone!! Any good study app recommendations?
HONNEA Reply
For which subject
Sinyinza
Biology:)
HONNEA
Hello everyone!! I want to be sure does exoskeleton consist of endoskeleton? plz help right nw
Sinyinza
Try this one and also biology Olevels
Sinyinza
Thanks!
HONNEA

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Source:  OpenStax, Biology. OpenStax CNX. Feb 29, 2016 Download for free at http://cnx.org/content/col11448/1.10
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