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The sliding filament model of contraction

When signaled by a motor neuron, a skeletal muscle fiber contracts as the thin filaments are pulled and then slide past the thick filaments within the fiber’s sarcomeres. This process is known as the sliding filament model of muscle contraction ( [link] ). The sliding can only occur when myosin-binding sites on the actin filaments are exposed by a series of steps that begins with Ca ++ entry into the sarcoplasm.

The sliding filament model of muscle contraction

This diagram shows how muscle contracts. The top panel shows the stretched filaments and the bottom panel shows the compressed filaments.
When a sarcomere contracts, the Z lines move closer together, and the I band becomes smaller. The A band stays the same width. At full contraction, the thin and thick filaments overlap.

Tropomyosin is a protein that winds around the chains of the actin filament and covers the myosin-binding sites to prevent actin from binding to myosin. Tropomyosin binds to troponin to form a troponin-tropomyosin complex. The troponin-tropomyosin complex prevents the myosin “heads” from binding to the active sites on the actin microfilaments. Troponin also has a binding site for Ca ++ ions.

To initiate muscle contraction, tropomyosin has to expose the myosin-binding site on an actin filament to allow cross-bridge formation between the actin and myosin microfilaments. The first step in the process of contraction is for Ca ++ to bind to troponin so that tropomyosin can slide away from the binding sites on the actin strands. This allows the myosin heads to bind to these exposed binding sites and form cross-bridges. The thin filaments are then pulled by the myosin heads to slide past the thick filaments toward the center of the sarcomere. But each head can only pull a very short distance before it has reached its limit and must be “re-cocked” before it can pull again, a step that requires ATP.

Atp and muscle contraction

For thin filaments to continue to slide past thick filaments during muscle contraction, myosin heads must pull the actin at the binding sites, detach, re-cock, attach to more binding sites, pull, detach, re-cock, etc. This repeated movement is known as the cross-bridge cycle. This motion of the myosin heads is similar to the oars when an individual rows a boat: The paddle of the oars (the myosin heads) pull, are lifted from the water (detach), repositioned (re-cocked) and then immersed again to pull ( [link] ). Each cycle requires energy, and the action of the myosin heads in the sarcomeres repetitively pulling on the thin filaments also requires energy, which is provided by ATP.

Skeletal muscle contraction

This multipart figure shows the mechanism of skeletal muscle contraction. In the top panel, the ADP and inorganic phosphate molecules are bound to the myosin motor head. In the middle panel, the ADP and phosphate come off the myosin motor and the direction of the power stroke is shown. In the bottom panel, a molecule of ATP is shown to bind the myosin motor head and the motor is reset.
(a) The active site on actin is exposed as calcium binds to troponin. (b) The myosin head is attracted to actin, and myosin binds actin at its actin-binding site, forming the cross-bridge. (c) During the power stroke, the phosphate generated in the previous contraction cycle is released. This results in the myosin head pivoting toward the center of the sarcomere, after which the attached ADP and phosphate group are released. (d) A new molecule of ATP attaches to the myosin head, causing the cross-bridge to detach. (e) The myosin head hydrolyzes ATP to ADP and phosphate, which returns the myosin to the cocked position.

Questions & Answers

Card 5 / 12: For whom would an appreciation of the structural characteristics of the human heart come more easily: an alien who lands on Earth, abducts a human, and dissects his heart, or an anatomy and physiology student performing a dissection of the heart on her very first day of class? Why?
Gelowe Reply
what are regular shaped cells with granules in the cytoplasam
Kabita Reply
I need sylubuss of clinical officers book
Omary Reply
cholesterol normal value is
less than 200mg/dl
100 to159mg/dL
Early this wk. I had some "A & P" questions & answers unfortunately didn't save them, Is there any way I can have them back ,so as 2 save them?. Thnx.
what are the functions of the female reproductive system
Lister Reply
it produces the female egg necessary for reproduction, called the Ova or Oocytes. The system is designed to transport the Ova to the site of fertilization.
Female reproductive system was mainly functioned to produce ova(ovum) (female eggs) Into which will be fertilized by male gamete to produce zygote
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asc if I try female reproductive system has two function the first is to produce egg cell and the second is to protact and nourish the offspring until birth
what is stercobilinogen
Hancerich Reply
fecal urobilinogen. Created by bacteria in the gut. a chemical that gives feces brown color.
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The rate of diffusion increases if the
What's the answer?
it's a breaking down of haemoglobin and it's a chemical made by bacteria
Thnx Dev Raj.
yup so any more
yes I sure do need more "Questions" & "Answers". I'm learning whole lot. Thnx.
what is the greatest muscle of the body
Lungu Reply
gluteus maximus
pls!!! more "A&P" questions & answers. Thnx.
Gluteus maximus
Describe anatomy of cardiovascular system?
cardiovascular system is a group of organs coming together to perform the circulation of blood. The organs invoked are the heart and the blood vessels with blood being the tissue. The heart is a pump and it pumps oxygenated blood through the systemic circuit and deoxygenated blood through the pulmon
pulmonary circuit.
more A&P questions pls. Thnx.
If an ANOVA yields a significant F value, you could rely on ________ to test significant differences between group means.
Dane Reply
what's ANOVA
analysis of variance
plz what you mean with "ANOVA" first
anova means analysis of variance, a statistical method in which the variation in a set of observations is divided into distinct components.
M value ot test
What does it mean by M value ot test?
formation of red blood cells
Biketi Reply
explain why... lower back pain in ovarian cancer
Srijoni Reply
we says that protoplasm is the living part of us How?
Muzamil Reply
is the leaving part of our cellular structure.
it is the leaving part of our blood cellular structure also
what is receptor?
Preity Reply
an organ or cell able to respond to light, heat, or other external stimulus and transmit a signal to a sensory nerve.
Has anyone taken the first exam?
hey what is the process after your food is swallowed? how long does it take to get to the stomache until it is released as waste?
Fednise Reply
that is such a broad question. as you begin to swallow its various doses down the alimentary canal that brings the food into your stomach.then depending on whether it's a protein carbohydrate fat that dictates what function takes place in your stomach. these are all steps of digestion.
typo sorry it's peristalsis , wave-like projections that push food down your alimentary canal etc. digestion starts in your mouth ends in your large intestines (colon anus)
some of the many processes of digestion include hydrolysis dehydration synthesis denaturation of proteins etc. you have to be more specific.
there's many different contributing factors the how long it takes food to convert into waste. remember fats, triglycerides proteins and carbohydrates all breakdown two different monomers and structures. you should be looking up metabolic processes.
depending how much fiber you have in your diet dictates how much water is brought to your intestines that has to do with excretion whether fiber is insoluble or soluble. this is an anatomy and physiology app. to simply say the stomach will empty its contents in 2 to 3 hours would do you a disservice
can the study of anatomy relate to medical technologies
Lean Reply
how can I understand micro biology and anatomy better.
someone to help me understand glycogeneogenesis
what are the major branches of the aorta?
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