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By the end of this section, you will be able to:
  • List the components of the endomembrane system
  • Recognize the relationship between the endomembrane system and its functions

The endomembrane system (endo = “within”) is a group of membranes and organelles ( [link] ) in eukaryotic cells that works together to modify, package, and transport lipids and proteins. It includes the nuclear envelope, lysosomes, and vesicles, which we’ve already mentioned, and the endoplasmic reticulum and Golgi apparatus, which we will cover shortly. Although not technically within the cell, the plasma membrane is included in the endomembrane system because, as you will see, it interacts with the other endomembranous organelles. The endomembrane system does not include the membranes of either mitochondria or chloroplasts.

Art connection

The left part of this figure shows the rough ER with an integral membrane protein embedded in it. The part of the protein facing the inside of the ER has a carbohydrate attached to it. The protein is shown leaving the ER in a vesicle that fuses with the cis side of the Golgi apparatus. The Golgi apparatus consists of several layers of membranes, called cisternae. As the protein passes through the cisternae, it is further modified by the addition of more carbohydrates. Eventually, it leaves the trans face of the Golgi in a vesicle. The vesicle fuses with the cell membrane so that the carbohydrate that was on the inside of the vesicle now faces the outside of the membrane. At the same time, the contents of the vesicle are ejected from the cell.
"Membrane and secretory proteins are synthesized in the rough endoplasmic reticulum (RER). The RER also sometimes modifies proteins. In this illustration, a (green) integral membrane protein in the ER is modified by attachment of a (purple) carbohydrate. Vesicles with the integral protein bud from the ER and fuse with the cis face of the Golgi apparatus. As the protein passes along the Golgi’s cisternae, it is further modified by the addition of more carbohydrates. After its synthesis is complete, it exits as integral membrane protein of the vesicle that bud from the Golgi’s trans face and when the vesicle fuses with the cell membrane the protein becomes integral portion of that cell membrane. (credit: modification of work by Magnus Manske)

If a peripheral membrane protein were synthesized in the lumen (inside) of the ER, would it end up on the inside or outside of the plasma membrane?

The endoplasmic reticulum

The endoplasmic reticulum (ER)    ( [link] ) is a series of interconnected membranous sacs and tubules that collectively modifies proteins and synthesizes lipids. However, these two functions are performed in separate areas of the ER: the rough ER and the smooth ER, respectively.

The hollow portion of the ER tubules is called the lumen or cisternal space. The membrane of the ER, which is a phospholipid bilayer embedded with proteins, is continuous with the nuclear envelope.

Rough er

The rough endoplasmic reticulum (RER)    is so named because the ribosomes attached to its cytoplasmic surface give it a studded appearance when viewed through an electron microscope ( [link] ).

In this transmission electron micrograph, the nucleus is the most prominent feature. The nucleolus is a circular, dark region inside the nucleus. A nuclear pore can be seen in the nuclear envelope that surrounds the nucleus. The rough endoplasmic reticulum surrounds the nucleus, appearing as many layers of membranes. A mitochondrion sits between the layers of the ER membrane.
This transmission electron micrograph shows the rough endoplasmic reticulum and other organelles in a pancreatic cell. (credit: modification of work by Louisa Howard)

Ribosomes transfer their newly synthesized proteins into the lumen of the RER where they undergo structural modifications, such as folding or the acquisition of side chains. These modified proteins will be incorporated into cellular membranes—the membrane of the ER or those of other organelles—or secreted from the cell (such as protein hormones, enzymes). The RER also makes phospholipids for cellular membranes.

If the phospholipids or modified proteins are not destined to stay in the RER, they will reach their destinations via transport vesicles that bud from the RER’s membrane ( [link] ).

Questions & Answers

define electric image.obtain expression for electric intensity at any point on earthed conducting infinite plane due to a point charge Q placed at a distance D from it.
Mateshwar Reply
explain the lack of symmetry in the field of the parallel capacitor
Phoebe Reply
pls. explain the lack of symmetry in the field of the parallel capacitor
does your app come with video lessons?
Ahmed Reply
What is vector
Ajibola Reply
Vector is a quantity having a direction as well as magnitude
tell me about charging and discharging of capacitors
Ahemen Reply
a big and a small metal spheres are connected by a wire, which of this has the maximum electric potential on the surface.
Bundi Reply
3 capacitors 2nf,3nf,4nf are connected in parallel... what is the equivalent capacitance...and what is the potential difference across each capacitor if the EMF is 500v
Prince Reply
equivalent capacitance is 9nf nd pd across each capacitor is 500v
four effect of heat on substances
Prince Reply
why we can find a electric mirror image only in a infinite conducting....why not in finite conducting plate..?
Rima Reply
because you can't fit the boundary conditions.
what is the dimensions for VISCOUNSITY (U)
what is thermodynamics
Aniket Reply
the study of heat an other form of energy.
heat is internal kinetic energy of a body but it doesnt mean heat is energy contained in a body because heat means transfer of energy due to difference in temperature...and in thermo-dynamics we study cause, effect, application, laws, hypothesis and so on about above mentioned phenomenon in detail.
It is abranch of physical chemistry which deals with the interconversion of all form of energy
what is colamb,s law.?
Muhammad Reply
it is a low studied the force between 2 charges F=q.q`\r.r
what is the formula of del in cylindrical, polar media
Birengeso Reply
prove that the formula for the unknown resistor is Rx=R2 x R3 divided by R3,when Ig=0.
what is flux
Bundi Reply
Total number of field lines crossing the surface area
Basically flux in general is amount of anything...In Electricity and Magnetism it is the total no..of electric field lines or Magnetic field lines passing normally through the suface
what is temperature change
a bottle of soft drink was removed from refrigerator and after some time, it was observed that its temperature has increased by 15 degree Celsius, what is the temperature change in degree Fahrenheit and degree Celsius
process whereby the degree of hotness of a body (or medium) changes
where The letter "Q" is the heat transferred in an exchange in calories, "m" is the mass of the substance being heated in grams, "c" is its specific heat capacity and the static value, and "ΔT" is its change in temperature in degrees Celsius to reflect the change in temperature.
what was the temperature of the soft drink when it was removed ?
15 degree Celsius
15 degree
ok I think is just conversion
15 degree Celsius to Fahrenheit
0 degree Celsius = 32 Fahrenheit
15 degree Celsius = (15×1.8)+32 =59 Fahrenheit
I dont understand
the question said you should convert 15 degree Celsius to Fahrenheit
To convert temperatures in degrees Celsius to Fahrenheit, multiply by 1.8 (or 9/5) and add 32.
what is d final ans for Fahrenheit and Celsius
it said what is temperature change in Fahrenheit and Celsius
the 15 is already in Celsius
So the final answer for Fahrenheit is 59
what is d final ans for Fahrenheit and Celsius
what are the effects of placing a dielectric between the plates of a capacitor
Bundi Reply
increase the capacitance.
besides increasing the capacitance, is there any?
mechanical stiffness and small size
so as to increase the capacitance of a capacitor
also to avoid diffusion of charges between the two plate since they are positive and negative.
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Source:  OpenStax, Biology 9-11 grades. OpenStax CNX. Mar 10, 2015 Download for free at https://legacy.cnx.org/content/col11766/1.2
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