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By the end of this section, you will be able to:
  • Describe how cancer is caused by uncontrolled cell growth
  • Understand how proto-oncogenes are normal cell genes that, when mutated, become oncogenes
  • Describe how tumor suppressors function
  • Explain how mutant tumor suppressors cause cancer

Cancer comprises many different diseases caused by a common mechanism: uncontrolled cell growth. Despite the redundancy and overlapping levels of cell cycle control, errors do occur. One of the critical processes monitored by the cell cycle checkpoint surveillance mechanism is the proper replication of DNA during the S phase. Even when all of the cell cycle controls are fully functional, a small percentage of replication errors (mutations) will be passed on to the daughter cells. If changes to the DNA nucleotide sequence occur within a coding portion of a gene and are not corrected, a gene mutation results. All cancers start when a gene mutation gives rise to a faulty protein that plays a key role in cell reproduction. The change in the cell that results from the malformed protein may be minor: perhaps a slight delay in the binding of Cdk to cyclin or an Rb protein that detaches from its target DNA while still phosphorylated. Even minor mistakes, however, may allow subsequent mistakes to occur more readily. Over and over, small uncorrected errors are passed from the parent cell to the daughter cells and amplified as each generation produces more non-functional proteins from uncorrected DNA damage. Eventually, the pace of the cell cycle speeds up as the effectiveness of the control and repair mechanisms decreases. Uncontrolled growth of the mutated cells outpaces the growth of normal cells in the area, and a tumor (“-oma”) can result.

Proto-oncogenes

The genes that code for the positive cell cycle regulators are called proto-oncogenes . Proto-oncogenes are normal genes that, when mutated in certain ways, become oncogenes , genes that cause a cell to become cancerous. Consider what might happen to the cell cycle in a cell with a recently acquired oncogene. In most instances, the alteration of the DNA sequence will result in a less functional (or non-functional) protein. The result is detrimental to the cell and will likely prevent the cell from completing the cell cycle; however, the organism is not harmed because the mutation will not be carried forward. If a cell cannot reproduce, the mutation is not propagated and the damage is minimal. Occasionally, however, a gene mutation causes a change that increases the activity of a positive regulator. For example, a mutation that allows Cdk to be activated without being partnered with cyclin could push the cell cycle past a checkpoint before all of the required conditions are met. If the resulting daughter cells are too damaged to undergo further cell divisions, the mutation would not be propagated and no harm would come to the organism. However, if the atypical daughter cells are able to undergo further cell divisions, subsequent generations of cells will probably accumulate even more mutations, some possibly in additional genes that regulate the cell cycle.

Questions & Answers

what is chromosomes?
Mabiya Reply
what is liver
Hassan Reply
liver is an organ in the body that meterbolise nutrients and produce bile.
Ekechi
what is the function of granum?
Gulfam
What is biology
Eric Reply
Biology is you
muayad
Biology is the natural science that studies life and living organisms, including their physical structure, chemical processes, molecular interactions, physiological mechanisms, development and. evolution
Suzette
biology is the study of living things and none living things
Ekechi
The mamalian endoskeleton has 206 bones
kaazim Reply
hii
Hannah
hi
Suzette
how you
Hannah
good thanks
Suzette
have you done the actual course?
Suzette
How many bones do human body have?
moses Reply
what are these geneti materials
ONELIA Reply
Name five parts of female reproductive system and state the function of each part
Angel Reply
What is biology
Angel
What is biology
Angel
biology is the study of all living organisms
ketchem
Ok
Angel
Name five parts of female reproductive system and state the function of each part
Angel
What is the meaning of respiration
Idriss Reply
the act or process of breathing .
Suzette
the process is very long as I know
Idriss
do you want more details ?
Suzette
yes offcourse
Smiso
what does the term diploid and haploid mean?
ONELIA
what is virgina
Shebas Reply
A female reproductive organs
Julius
fuvu LA binadam linamifupa mingapi?
Hamis Reply
explain dicot n monocot plant
Henry Reply
Di= 2cotiledon mono=cotiledon
muayad
Mono = 1 cotiledon
muayad
what is virginia
Shebas
A Virginia is a part of a female ,the passage of a child during child birth, receiver of the penis and the passage of menstral flow
Idriss
what is biology
Hassan Reply
what is liver
Hassan
Biology is the study of living organisms
Gifty
is the study of life of living organisms
Chansa
study all about organisms like their reproduction, evolution , behaviour Physiology, etc
Ubaid
this is what we call "life"@
Chansa
is the study of living organisms on earth
okubasu
It is the study of living organism
Idriss
Biology is the study of all living organisms
ketchem
what is copulation
ketchem
metabolism is the anabolic and catabolic process of how food are broken from large molecules into smaller soluble molecules.
Prince Reply
what is Metabolism
Nakagolo Reply
Metabolism are all chemical reaction that takes place inside cells including those that takes energy and realise energy
Idriss
Describe digestion in a cat
Nakagolo Reply
what is hoemostasis
Nakagolo
Way of animals to keep internal conditions
muayad
balancing of water in the body
Dennis

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Source:  OpenStax, Biology. OpenStax CNX. Feb 29, 2016 Download for free at http://cnx.org/content/col11448/1.10
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