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The microscopic structural unit of compact bone is called an osteon    , or Haversian system. Each osteon is composed of concentric rings of calcified matrix called lamellae (singular = lamella). Running down the center of each osteon is the central canal    , or Haversian canal, which contains blood vessels, nerves, and lymphatic vessels. These vessels and nerves branch off at right angles through a perforating canal    , also known as Volkmann’s canals, to extend to the periosteum and endosteum.

The osteocytes are located inside spaces called lacunae (singular = lacuna), found at the borders of adjacent lamellae. As described earlier, canaliculi connect with the canaliculi of other lacunae and eventually with the central canal. This system allows nutrients to be transported to the osteocytes and wastes to be removed from them.

Spongy (cancellous) bone

Like compact bone, spongy bone    , also known as cancellous bone, contains osteocytes housed in lacunae, but they are not arranged in concentric circles. Instead, the lacunae and osteocytes are found in a lattice-like network of matrix spikes called trabeculae    (singular = trabecula) ( [link] ). The trabeculae may appear to be a random network, but each trabecula forms along lines of stress to provide strength to the bone. The spaces of the trabeculated network provide balance to the dense and heavy compact bone by making bones lighter so that muscles can move them more easily. In addition, the spaces in some spongy bones contain red marrow, protected by the trabeculae, where hematopoiesis occurs.

Diagram of spongy bone

This illustration shows the spongy bone within the proximal epiphysis of the femur in two successively magnified images. The lower-magnification image shows two layers of crisscrossing trabeculae. The surface of each is dotted with small black holes which are the openings of the canaliculi. One of the trabeculae is in a cross section to show its internal layers. The outermost covering of the lamellae is called the endosteum. This endosteum surrounds several layers of concentric lamellae. The higher-magnification image shows the cross section of the trabeculae more clearly. Three concentric lamellae are shown in this view, each possessing perpendicular black lines. These lines are the canaliculi and are oriented on the round lamellae similar to the spokes of a wheel. In between the lamellae are small cavities called lacunae which house cells called osteocytes. In addition, two large osteoclasts are seated on the outer edge of the outermost lamellae. The outermost lamellae are also surrounded by groups of small, white, osteoblasts.
Spongy bone is composed of trabeculae that contain the osteocytes. Red marrow fills the spaces in some bones.

Aging and the…

Skeletal system: paget’s disease

Paget’s disease usually occurs in adults over age 40. It is a disorder of the bone remodeling process that begins with overactive osteoclasts. This means more bone is resorbed than is laid down. The osteoblasts try to compensate but the new bone they lay down is weak and brittle and therefore prone to fracture.

While some people with Paget’s disease have no symptoms, others experience pain, bone fractures, and bone deformities ( [link] ). Bones of the pelvis, skull, spine, and legs are the most commonly affected. When occurring in the skull, Paget’s disease can cause headaches and hearing loss.

Paget's disease

This illustration shows the normal skeletal structure of the legs from an anterior view. The flesh of the legs and feet are outlined around the skeleton for reference. A second illustration shows the legs of someone with Paget’s disease. The affected person’s left femur is curved outward, causing the left leg to be bowed and shorter than the right leg.
Normal leg bones are relatively straight, but those affected by Paget’s disease are porous and curved.

What causes the osteoclasts to become overactive? The answer is still unknown, but hereditary factors seem to play a role. Some scientists believe Paget’s disease is due to an as-yet-unidentified virus.

Paget’s disease is diagnosed via imaging studies and lab tests. X-rays may show bone deformities or areas of bone resorption. Bone scans are also useful. In these studies, a dye containing a radioactive ion is injected into the body. Areas of bone resorption have an affinity for the ion, so they will light up on the scan if the ions are absorbed. In addition, blood levels of an enzyme called alkaline phosphatase are typically elevated in people with Paget’s disease.

Bisphosphonates, drugs that decrease the activity of osteoclasts, are often used in the treatment of Paget’s disease. However, in a small percentage of cases, bisphosphonates themselves have been linked to an increased risk of fractures because the old bone that is left after bisphosphonates are administered becomes worn out and brittle. Still, most doctors feel that the benefits of bisphosphonates more than outweigh the risk; the medical professional has to weigh the benefits and risks on a case-by-case basis. Bisphosphonate treatment can reduce the overall risk of deformities or fractures, which in turn reduces the risk of surgical repair and its associated risks and complications.

Blood and nerve supply

The spongy bone and medullary cavity receive nourishment from arteries that pass through the compact bone. The arteries enter through the nutrient foramen    (plural = foramina), small openings in the diaphysis ( [link] ). The osteocytes in spongy bone are nourished by blood vessels of the periosteum that penetrate spongy bone and blood that circulates in the marrow cavities. As the blood passes through the marrow cavities, it is collected by veins, which then pass out of the bone through the foramina.

In addition to the blood vessels, nerves follow the same paths into the bone where they tend to concentrate in the more metabolically active regions of the bone. The nerves sense pain, and it appears the nerves also play roles in regulating blood supplies and in bone growth, hence their concentrations in metabolically active sites of the bone.

Diagram of blood and nerve supply to bone

This illustration shows an anterior view if the right femur. The femur is split in half lengthwise to show its internal anatomy. The outer covering of the femur is labeled the periosteum. Within it is a thin layer of compact bone that surrounds a central cavity called the medullary or marrow cavity. This cavity is filled with spongy bone at both epiphyses. A nutrient artery and vein travels through the periosteum and compact bone at the center of the diaphysis. After entering the bone, the nutrient arteries and veins spread throughout the marrow cavity in both directions. Some of the arteries and veins in the marrow cavity also spread into the spongy bone within the distal and proximal epiphyses. However, additional blood vessels called the metaphyseal arteries and the metaphyseal veins enter into the metaphysis from outside of the bone.
Blood vessels and nerves enter the bone through the nutrient foramen.

Watch this video to see the microscopic features of a bone.

Chapter review

A hollow medullary cavity filled with yellow marrow runs the length of the diaphysis of a long bone. The walls of the diaphysis are compact bone. The epiphyses, which are wider sections at each end of a long bone, are filled with spongy bone and red marrow. The epiphyseal plate, a layer of hyaline cartilage, is replaced by osseous tissue as the organ grows in length. The medullary cavity has a delicate membranous lining called the endosteum. The outer surface of bone, except in regions covered with articular cartilage, is covered with a fibrous membrane called the periosteum. Flat bones consist of two layers of compact bone surrounding a layer of spongy bone. Bone markings depend on the function and location of bones. Articulations are places where two bones meet. Projections stick out from the surface of the bone and provide attachment points for tendons and ligaments. Holes are openings or depressions in the bones.

Bone matrix consists of collagen fibers and organic ground substance, primarily hydroxyapatite formed from calcium salts. Osteogenic cells develop into osteoblasts. Osteoblasts are cells that make new bone. They become osteocytes, the cells of mature bone, when they get trapped in the matrix. Osteoclasts engage in bone resorption. Compact bone is dense and composed of osteons, while spongy bone is less dense and made up of trabeculae. Blood vessels and nerves enter the bone through the nutrient foramina to nourish and innervate bones.

Questions & Answers

What is anatomy !?
Arun Reply
the study of different parts of body to discover situation structure and economy
Aurelia
Anatomy is a study of structure of the body parts and it's consistents. Anatomy is a Greek word which means to cut up
Asma
Which book is perfect for anatomy ? among BD , Vishram , Gray's !?
Arun
iama Student of 1st year
Arun
Ashalata Anatomy text book
Johanna
The study of various body structures and their relationship with one another
Onwochie
Ross and Wilson's anatomy textbook
Onwochie
Anatomy is the study of human structure, functions and other relative organs in the system
Ayorinde
ross and willson book
Tifu
the study of structure unite of body
Faisal
thanks to all
Arun
Does anyone Read A.K dutta?
Arun
refer to the study of human body structure
SAID
which nerve orginates from pons
Kripa Reply
trigeminal nerve
madhuri
demand and supply rules
jamac Reply
compative demand and supply
jamac
compare demand and supply
jamac
what are simple epithelial tissues
Ushie Reply
is a type of tissue which covers the external and internal part of the body
Fatou
more information would be better understanding.
Tasha
what is platelets
Lilian Reply
platelet is also known as thrombocyte.thrombo means clot.it is a formed element of blood formed from fragment of megakaryocyte surrounded by plasma membrane in the redbone marow
Adeyemo
what is diabetes insipidus
namrata Reply
it is an infection due to less or no secretion of ADH characterized by excretion of dilute urine
Meshack
Infection? I don't think any form of diabetes, whether it's mellitus or insipidus, is caused by an infection.
Matias
ya
Akanyijuka
it is the disorder of salt & water metabolism
Emma
diabetes inspidus is a condition were the liver can't produce insulin to convert the excess sugar to glycogen.
mangs
sorry that is for diabetes mellitus
mangs
what is septal cartilage
Arthur Reply
I don't understand please
Esther Reply
hey
Austine
good evening boss
Austine
Evening
Esther
good evening
Melissa
evening
Vitus
hi
Rodgers
good morning
Aurelia
hello
Helsa
you guys are from ?
Aurelia
Philippines
Helsa
im from india
Aurelia
Hello
Amos
why
Sami
wat
Rodgers
what's that
Gift
what's the medulla?
alhussiney Reply
The medulla oblongata or simply medulla is a long stem-like structure which makes up the lower part of the brainstem. It is anterior and partially inferior to the cerebellum
Ludmila
define bone in simple terms
Mhoses Reply
bones are made up by collagen and calcium phosphate
Aurelia
yes
Confidence
Bones are the hard large calcareous connective tissue of which the adult skeleton of most vertebrates is chiefly composed
Olalekan
Bone is the substance that forms skeleton
Frances
good morning
Mrinal
Skelton muscles is any disorder of calcium
Mrinal
Bones protect the various organs of the body
Celina
Bone is a hard strong and durable type of connective tissue
Bkv
bone is a hard, calcareous connective tissue which gives structural support to the body and helpless in its locomotion!
Divya
It also is the main site for synthesis of the RBCs
Divya
thanks for your answers
Mhoses
A diagram of epithelial tissue
Emmanuel Reply
What does the urinary regulate blood pressure
Jennifer Reply
functions of melatonin
marion Reply
d. inversely proportional
John Reply
Airway resistance in the human lung is? a. Greatest in the generation of distal bronchioles in healthy people because these airways have the smallest radii b. Not increased during a forced expiration in a healthy subject c. Decreased when breathing through the mouth d. Inversely proportional
Maryam Reply

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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