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Conservation of bicarbonate in the kidney

This diagram depicts a cross section of the left wall of a kidney proximal tubule. The wall is composed of two block-shaped cells arranged vertically one on top of each other. The lumen of the proximal tubule is to the left of the two cells. Yellow-colored urine is flowing through the lumen. There is a small strip of blue interstitial fluid to the right of the two cells. To the right of the interstitial fluid is a cross section of a blood vessel. A loop of chemical reactions is occurring in the diagram. Within the lumen of the proximal tubule, HCO three minus is combining with an H plus ion that enters the lumen from a proximal tubule cell. This reaction forms H two CO three. H two CO three then breaks into H two O and CO two, a reaction catalyzed by the enzyme carbonic anhydrase. The CO two then moves from the lumen of the proximal tubule into one of the proximal tubule cells. There, the reaction runs in reverse, with CO two combining with H two O to form H two CO three. The H two CO three then splits into H plus and HCO three minus. The H plus moves into the lumen, reinitiating the first step of the loop. The HCO three minus leaves the proximal tubule cell and enters the blood stream.
Tubular cells are not permeable to bicarbonate; thus, bicarbonate is conserved rather than reabsorbed. Steps 1 and 2 of bicarbonate conservation are indicated.

It is also possible that salts in the filtrate, such as sulfates, phosphates, or ammonia, will capture hydrogen ions. If this occurs, the hydrogen ions will not be available to combine with bicarbonate ions and produce CO 2 . In such cases, bicarbonate ions are not conserved from the filtrate to the blood, which will also contribute to a pH imbalance and acidosis.

The hydrogen ions also compete with potassium to exchange with sodium in the renal tubules. If more potassium is present than normal, potassium, rather than the hydrogen ions, will be exchanged, and increased potassium enters the filtrate. When this occurs, fewer hydrogen ions in the filtrate participate in the conversion of bicarbonate into CO 2 and less bicarbonate is conserved. If there is less potassium, more hydrogen ions enter the filtrate to be exchanged with sodium and more bicarbonate is conserved.

Chloride ions are important in neutralizing positive ion charges in the body. If chloride is lost, the body uses bicarbonate ions in place of the lost chloride ions. Thus, lost chloride results in an increased reabsorption of bicarbonate by the renal system.

Disorders of the…

Acid-base balance: ketoacidosis

Diabetic acidosis, or ketoacidosis, occurs most frequently in people with poorly controlled diabetes mellitus. When certain tissues in the body cannot get adequate amounts of glucose, they depend on the breakdown of fatty acids for energy. When acetyl groups break off the fatty acid chains, the acetyl groups then non-enzymatically combine to form ketone bodies, acetoacetic acid, beta-hydroxybutyric acid, and acetone, all of which increase the acidity of the blood. In this condition, the brain isn’t supplied with enough of its fuel—glucose—to produce all of the ATP it requires to function.

Ketoacidosis can be severe and, if not detected and treated properly, can lead to diabetic coma, which can be fatal. A common early symptom of ketoacidosis is deep, rapid breathing as the body attempts to drive off CO 2 and compensate for the acidosis. Another common symptom is fruity-smelling breath, due to the exhalation of acetone. Other symptoms include dry skin and mouth, a flushed face, nausea, vomiting, and stomach pain. Treatment for diabetic coma is ingestion or injection of sugar; its prevention is the proper daily administration of insulin.

A person who is diabetic and uses insulin can initiate ketoacidosis if a dose of insulin is missed. Among people with type 2 diabetes, those of Hispanic and African-American descent are more likely to go into ketoacidosis than those of other ethnic backgrounds, although the reason for this is unknown.

Chapter review

A variety of buffering systems exist in the body that helps maintain the pH of the blood and other fluids within a narrow range—between pH 7.35 and 7.45. A buffer is a substance that prevents a radical change in fluid pH by absorbing excess hydrogen or hydroxyl ions. Most commonly, the substance that absorbs the ion is either a weak acid, which takes up a hydroxyl ion (OH - ), or a weak base, which takes up a hydrogen ion (H + ). Several substances serve as buffers in the body, including cell and plasma proteins, hemoglobin, phosphates, bicarbonate ions, and carbonic acid. The bicarbonate buffer is the primary buffering system of the IF surrounding the cells in tissues throughout the body. The respiratory and renal systems also play major roles in acid-base homeostasis by removing CO 2 and hydrogen ions, respectively, from the body.

Questions & Answers

what is the relationship between Clinical officer general, unqualified professionals and traditional healers?
Purity Reply
is that how the microscopic anatomy is
Elizabeth Reply
to understand the structures of the body. to understand how the structures of the body work . To understand how the structures of the body work and support the functions of life.
Dora Reply
procedures that removes waste from body when kidneys dont function properly..
maribel Reply
Want to join
What is dialisis
Friday Reply
When kidney is not functioning properly than with the help of dialysis blood filtration is occur Or we can say that it is a process through which filtration of blood is done
dialysis is a process of removing wastes, excess fluid ,impurities from the blood and to correct electrolytes imbalance such as sodium, potassium and calcium etc with the help of dialysis machine.when the kidney can't do their job.
describe anatomical position
Getrude Reply
The erect position of the body with the face directed forward, the arms at the side, and the palms of the hands facing forward, used as a reference in describing the relation of body parts to one another
Somebody to explain for me the duties of specialist obstetrician
Definition of an anatomy
Oppong Reply
hy oppong wat course do u offer
b pharmacy all subject complete notes
the study of the body's structures scientifically
what is regional anatomy ?
Jharana Reply
regional anatomy - the study of anatomy based on regions or divisions of the body and emphasizing the relations between various structures (muscles and nerves and arteries etc.) in that region.
it's the scientific study of the body's structures in a particular region of the body, to study and understand how the body's structures in that region work together and the relations between them.
what is joint
ISHQ Reply
I want to learn English
who are you?
joining the academy
what is gross anatomy ?
Jharana Reply
what is pharynx
membrane behind the nose
Gross anatomy is the study of anatomy at the visible or (macroscopic) level
how does blood gets into the heart
through the inferior and superior vena cava
it's the anatomy of complex body structures that can be seen without the aid of a microspe.
it is the study of large body structures that can be observed without the aid of a microscope
state factors that affect sterilization (10marks)
what facilitate an embryo?
what is anatomy
Danish Reply
study of internal structure of living organism
study of body's structures scientifically.
is the study structure of body
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risk for hemodialysis
what are the types of membranes
Kevin Reply
How prepare a assignment on musciskeleton
sonugora Reply
how does the heart function
Pricey Reply
what re the three layers of the skin
endoderm, mesoderm and ectoderm
epidermis, dermis and subcutaneous
epidermis, dermis and hypodermis
the heart functions by electric impulse
Ectoderm, mesoderm and endoderm
what you guys mentioned are the layers of the heart
how does the heart get blood itself
by coronary circulation
yeah the coronary artery supplies the heart muscle with oxygen and nutriente

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