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View the University of Michigan WebScope at (External Link) to explore the tissue sample in greater detail. If you zoom on the cells at the outermost layer of this section of skin, what do you notice about the cells?

Stratum basale

The stratum basale    (also called the stratum germinativum) is the deepest epidermal layer and attaches the epidermis to the basal lamina, below which lie the layers of the dermis. The cells in the stratum basale bond to the dermis via intertwining collagen fibers, referred to as the basement membrane. A finger-like projection, or fold, known as the dermal papilla    (plural = dermal papillae) is found in the superficial portion of the dermis. Dermal papillae increase the strength of the connection between the epidermis and dermis; the greater the folding, the stronger the connections made ( [link] ).

Layers of the epidermis

This illustration shows a cross section of the epidermis. The cells of the innermost layer, the stratum basale, are large and have a purple nucleus. The stratum basale curls around the dermis, which projects into the epidermis. The stratum basale contains four layers of large, triangle-shaped keratinocytes. Fibers are visible within the spaces between keratinocytes in the stratum basale. A melanocyte is also present in this layer. The melanocyte possesses finger-like projections extending from its main cell body. The projections branch through the extracellular spaces between nearby keratinocytes. Above the stratum basale is the stratum spinosum which consists of 8 layers of oval-shaped keratinocytes. The nucleus is present in these keratinocytes, but has faded to a lighter purple. The stratum granulosum contains five layers of keratinocytes, each containing spots in its cytoplasm, labeled the lamellar granules. The stratum lucidium contains 4 layers of diamond-shaped cells with no nucleus. The stratum corneum contains 9 layers of keratinocytes with no nucleus , nor cytoplasm. A few of the cells in the topmost layer of the stratum corneum are flaking off from the skin.
The epidermis of thick skin has five layers: stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.

The stratum basale is a single layer of cells primarily made of basal cells. A basal cell    is a cuboidal-shaped stem cell that is a precursor of the keratinocytes of the epidermis. All of the keratinocytes are produced from this single layer of cells, which are constantly going through mitosis to produce new cells. As new cells are formed, the existing cells are pushed superficially away from the stratum basale. Two other cell types are found dispersed among the basal cells in the stratum basale. The first is a Merkel cell    , which functions as a receptor and is responsible for stimulating sensory nerves that the brain perceives as touch. These cells are especially abundant on the surfaces of the hands and feet. The second is a melanocyte    , a cell that produces the pigment melanin. Melanin gives hair and skin its color, and also helps protect the living cells of the epidermis from ultraviolet (UV) radiation damage.

In a growing fetus, fingerprints form where the cells of the stratum basale meet the papillae of the underlying dermal layer (papillary layer), resulting in the formation of the ridges on your fingers that you recognize as fingerprints. Fingerprints are unique to each individual and are used for forensic analyses because the patterns do not change with the growth and aging processes.

Stratum spinosum

As the name suggests, the stratum spinosum    is spiny in appearance due to the protruding cell processes that join the cells via a structure called a desmosome    . The desmosomes interlock with each other and strengthen the bond between the cells. It is interesting to note that the “spiny” nature of this layer is an artifact of the staining process. Unstained epidermis samples do not exhibit this characteristic appearance. The stratum spinosum is composed of eight to 10 layers of keratinocytes, formed as a result of cell division in the stratum basale ( [link] ). Interspersed among the keratinocytes of this layer is a type of dendritic cell called the Langerhans cell    , which functions as a macrophage by engulfing bacteria, foreign particles, and damaged cells that occur in this layer.

Questions & Answers

body, muscle and regional of structures in the body
Harmony Reply
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Harmony
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In a four-chambered heart, such as that in humans, there are two ventricles that operate in a double circulatory system: the right ventricle pumps blood into the pulmonary circulation to the lungs, and the left ventricle pumps blood into the systemic circulation through the aorta.
yes
anjali
hi
A 23-year-old basketball player mentally rehearses free throw shots while lying in bed. Which option best describesthe area of the brain that is involved in generating a motor image of this action in the absence of actual movement?
Rai
hapothalamus
Prashant
a 67-year-old man has a stroke. one week later, he experiences sudden and uncontrolled flailing, ballistic movements of his limbs. which part of the man’s brain is most likely to have been damaged by the stroke?
Rai
primary motor cortex.. (principal area of cerebrum)
Khawaja
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Gift Reply
the mass of the solute the temperature of theenvironment the solvent density and the distance traveled
Sulaiman
ok.
Thobok
sorry what are the common meaning of haemostatis
Juma Reply
homeostasis is the steady internal physical and chemical conditions maintaining by living systems
Sulaiman
what are the negatives feedback regulation of ADH
Nansi Reply
what is the the differences between DNA and RNA?
Mustapha
The major differences between the DNA and RNA are contain of double stranded and single stranded which the DNA contain duoble stranded and RNA contain single stranded.
Juma
what are the negatives feedback regulation of ADH before this we confused just verify long term of ADH firstly
Juma
How many genes consist of DNA?
Omaryare
omaryare muhyadiin when you talk about genes, is the material formed in a DNA genes have form like plasma have many genes round there
Juma
aldosterone, renin
Conan
DNA contains the sugar deoxyribone while RNA contains the sugar ribose the only difference between ribose and deoxyribone is that ribose has one more- OH group than deoxyribone which has -H attached to the second carbon in the ring DNA is a double stranded molecules RNA is a single strnded molecul
Sulaiman
yes
Thobok
in human genes very in size from a few hundred DNA based to more than 2million bases
Sulaiman
to know the different structures of the body To know how the body works To know more about our body parts
Deitdre Reply
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Juma
do you need any explanation when reading this book?
janet Reply
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Hashir
yes
Balogun
Yes
Mariam
yes
Sale
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Mustapha
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Sulaiman
compare and contrast the operation of homeostasis
Dinelle Reply
what is the difference between an ionic, polar covalent and nonpolar covalent bond?
Dinelle
In summary, the bond has different in electronegativity.
Balogun
sorry help me to get the definition of hemostasis or the meaning
Juma
the definition of distal
Dinelle Reply
farthest away from the attachment point.
felix
Distal, is the farthest possition from the origin or midle point
Juma
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Noor Reply
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Juma
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Rafiullah Reply
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Juma
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mukhtaar Reply
which part of the body produces blood
aadil
give me answer
aadil
Red blood cells are formed in the red bone marrow ofbones. Stem cells in the red bone marrow called hemocytoblasts give rise to all of the formed element
mukhtaar
what is hemocytoblasts
Fatima
hemocytoblasts are stem cells in red bone marrow which give rise the all of formed elements
Khawaja
Discuss clonal theory in physiology and its application in measles infection in a 6yr child? Can anyone help me
Isaac Reply
Capillary permeability
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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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