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Antidiuretic hormone (adh)

Diuretics are drugs that can increase water loss by interfering with the recapture of solutes and water from the forming urine. They are often prescribed to lower blood pressure. Coffee, tea, and alcoholic beverages are familiar diuretics. ADH, a 9-amino acid peptide released by the posterior pituitary, works to do the exact opposite. It promotes the recovery of water, decreases urine volume, and maintains plasma osmolarity and blood pressure. It does so by stimulating the movement of aquaporin proteins into the apical cell membrane of principal cells of the collecting ducts to form water channels, allowing the transcellular movement of water from the lumen of the collecting duct into the interstitial space in the medulla of the kidney by osmosis. From there, it enters the vasa recta capillaries to return to the circulation. Water is attracted by the high osmotic environment of the deep kidney medulla.

Endothelin

Endothelins , 21-amino acid peptides, are extremely powerful vasoconstrictors. They are produced by endothelial cells of the renal blood vessels, mesangial cells, and cells of the DCT. Hormones stimulating endothelin release include angiotensin II, bradykinin, and epinephrine. They do not typically influence blood pressure in healthy people. On the other hand, in people with diabetic kidney disease, endothelin is chronically elevated, resulting in sodium retention. They also diminish GFR by damaging the podocytes and by potently vasoconstricting both the afferent and efferent arterioles.

Natriuretic hormones

Natriuretic hormones are peptides that stimulate the kidneys to excrete sodium—an effect opposite that of aldosterone. Natriuretic hormones act by inhibiting aldosterone release and therefore inhibiting Na + recovery in the collecting ducts. If Na + remains in the forming urine, its osmotic force will cause a concurrent loss of water. Natriuretic hormones also inhibit ADH release, which of course will result in less water recovery. Therefore, natriuretic peptides inhibit both Na + and water recovery. One example from this family of hormones is atrial natriuretic hormone (ANH), a 28-amino acid peptide produced by heart atria in response to over-stretching of the atrial wall. The over-stretching occurs in persons with elevated blood pressure or heart failure. It increases GFR through concurrent vasodilation of the afferent arteriole and vasoconstriction of the efferent arteriole. These events lead to an increased loss of water and sodium in the forming urine. It also decreases sodium reabsorption in the DCT. There is also B-type natriuretic peptide (BNP) of 32 amino acids produced in the ventricles of the heart. It has a 10-fold lower affinity for its receptor, so its effects are less than those of ANH. Its role may be to provide “fine tuning” for the regulation of blood pressure. BNP’s longer biologic half-life makes it a good diagnostic marker of congestive heart failure ( [link] ).

Parathyroid hormone

Parathyroid hormone (PTH) is an 84-amino acid peptide produced by the parathyroid glands in response to decreased circulating Ca ++ levels. Among its targets is the PCT, where it stimulates the hydroxylation of calcidiol to calcitriol (1,25-hydroxycholecalciferol, the active form of vitamin D). It also blocks reabsorption of phosphate (PO 3 ), causing its loss in the urine. The retention of phosphate would result in the formation of calcium phosphate in the plasma, reducing circulating Ca ++ levels. By ridding the blood of phosphate, higher circulating Ca ++ levels are permitted.

Major hormones that influence gfr and rfb

This table shows the stimulus, effect on GFR (glomerular filtration rate), and effect on RBF (renal blood flow) for a variety of vasoconstrictors and vasodilators. The first vasoconstrictor is input from the sympathetic nerves that result in the secretion of epinephrine and norepinephrine. The stimulus is a decrease in extracellular fluid volume (ECFV). The second vasoconstrictor is angiotensin II. The stimulus is a decrease in ECFV. The third vasoconstrictor is endothelin. The stimulus is an increase in stretch, bradykinin, angiotensin II, and epinephrine along with a decrease in ECFV. All three of these vasoconstrictors decrease GFR and also decrease RBF. The first vasodilator is the prostaglandins PGE1, PGE2, and PGI2. The stimulus is a decrease in ECFV, an increase in shear stress, and  an increase in angiotensin II. The second vasodilator is nitric oxide (NO). The stimulus is increasing shear stress, acetylcholine, histamine, bradykinin, ATP, and adenosine. The third vasodilator is bradykinin. The stimulus is the presence of prostaglandins and a decrease in angiotensin-converting enzyme. The fourth vasodilator is natriuretic peptides, including ANP and B-type. The stimulus is an increase in ECFV. All four of the vasodilators increase GFR and also increase RBF, with the exception of the natriuretic peptides, which cause no change in RBF. Prostaglandins also either increase or have no effect on GFR.

Chapter review

Endocrine hormones act from a distance and paracrine hormones act locally. The renal enzyme renin converts angiotensinogen into angiotensin I. The lung enzyme, ACE, converts angiotensin I into active angiotensin II. Angiotensin II is an active vasoconstrictor that increases blood pressure. Angiotensin II also stimulates aldosterone release from the adrenal cortex, causing the collecting duct to retain Na + , which promotes water retention and a longer-term rise in blood pressure. ADH promotes water recovery by the collecting ducts by stimulating the insertion of aquaporin water channels into cell membranes. Endothelins are elevated in cases of diabetic kidney disease, increasing Na + retention and decreasing GFR. Natriuretic hormones, released primarily from the atria of the heart in response to stretching of the atrial walls, stimulate Na + excretion and thereby decrease blood pressure. PTH stimulates the final step in the formation of active vitamin D3 and reduces phosphate reabsorption, resulting in higher circulating Ca ++ levels.

Questions & Answers

good evening, my question is what are function of metal in human body like aluminum?
Yosef Reply
please want you to help me in understanding digestive system
Hamidu Reply
this is muscular system?
Patel Reply
bruh moment
Viana
It is an organ system consisting of skeletal ,smooth and cardiac muscles
mishra
im too retarded to be here
Viana
naww Viana, I know it's hard to absorb info, I'm having the same issue, but keep practising, chin up.
Katarina
what is the question
Amir
to have a better understanding as to how our human bodies function. the knowledge we gain can improve our quality of life. Without our study of anatomy how could a doctor know what prescription to give us when our bodies is being attacked by a bacteria? We wouldn't!
Robin Reply
discuss nervers system in human being life.
Allen Reply
neuralgia what is other name of it
Muniba
how are neurons adapted to their function
Namiyaba Reply
machenic support production of blood cells locomotion protection of delicate organs
Ackson Reply
what are hormones?
Ackson
what is anatomy
Juma Reply
what are the functions of bones
Michael
To support and control the movements of the body
Mu
the study of human body is called anatomy
mishra
the study of human body is nt only anatomy but also physiology and histology
Evans
ooops lol I thought Michael was the one with the questions so sorry people. yes anatomy is the study of the body(structure)and it's physiology (functions).
Mu
what are the muscles of respiration?
Dorisha
Hi everyone, Why actyl choline decreases blood pressure although it affects adrenal gland leading it to secret adrenaline and noradrenaline which increase blood pressure?
cholinergic receptors are mostly under Parasympathetic response while adrenergic (norepinephrine) receptors are mostly sympathetic although they are cholinergic adrenergic receptors as well
Ayodeji
why do I have pain in my right side of the stomach I had ulcer
Mohammed
go to gastro physician may be but some time it is a gas
Amir
vocal cords
MT Reply
musah was admitted to your ward yesterday with traumatic amputation of the right thump . he complained this morning that he has not passed enough urine. Questions. 1) will you consider his complain to be pathological or physiological?. 2) in less than three sentences, justify your opinion. 3) Apply your understanding of the renin- angiotensin-aldosterone system to explain the factors and mechanisms accounting for his complains.
Ellen Reply
please i want you guys to help understand digestive system
Hamidu
digestive system is the system that ingestion breakdown by mechanical and chemicals via mouth to stomach throughout alimentary canal
Girma
please alimentary canal what it is and it functions
Hamidu
Ellen de condition is physiological, traumatic amputation causes the body to go to shock in which less blood is sent to the organ (kidney) causing decreased in blood pressure in the renal tubules and low glomerular filtrate will be produced as ultrafiltration can't occur.
Nana
thanks
Hamidu
Alimentary canal is a long tube that runs from the mouth to the anus and helps in peristalsis and digestion of food to smaller soluble particles to be absorbed into the blood and assimilated into the cells for to obtain energy for cellular function
Nana
much thanks
Hamidu
accessory organs it functions
Hamidu
which accessory organs
Nana
that's the tongue,salivary gland and the teeth
Hamidu
accessory organ the organ which not part of digestive tract e.g tongue salivary gland liver pancreas gallbladder etc which heps in digestion
Salahudin
salivary glands (parotid, sublingual and submandibular) for secreting saliva for lubrucation and salivary amylase in carbohydrates breakdown in the mouth.teeth helps in chewing, tongue rolls de food into bolus.gallbladder stores biles produced by the liver and helps emulsify fats.liver detoxify food
Nana
my question is what is the location of pituitary gland in anatomy
Amir
what is average value of hair at scalp give me answer .if no one know about answer .so than I given answer
Amir
The value of hair at scalp is 100.000
Amir
please explain
Agbosu
100000 to 150000 scalp
Salahudin
OK good
Amir
where is cartilage present in large amount a)Thoracic cage b) head c) lower limb d)upper limb
Amir
the human scalp has almost 100000 to 150000 hair follicles from hair grow and come out the life of single hair grows have three different stages of hair growth it is considered normal if have lose 50 hairs approx
Salahudin
thinks
Salahudin
thoracic cage have 12
Salahudin
what is AV node?
Salahudin
amir khan
Salahudin
pituitary gland is small oval shape which present in brain
Salahudin
AV stands for atrioventricular node, it consist of cardiac muscle tissue and its lies in the right atrium along the lower part of the interartrial septum..
Om
what is the function of AV and SA nodes
Salahudin
SA node is the pacemaker of the human heart and it generates an electrical signal that cause upper chambers (atria) to contract .. the signal that passes through the AV node to the lower heart chambers (ventricles) causing them to contract or pump ...
Om
the mineral salt which break up a large portion of bone tissue is
Aurora Reply
calcium
Calcium
Sawda
please I need help. musah was admitted to your ward yesterday with traumatic amputation of the right thump. he complained this morning that he has not passed enough urine. Questions. 1). will you consider his complain to be pathological or physiological?.
Ellen
2). In less than three sentences, justify your opinion.
Ellen
Physiological
Ruth
musah copmlan to be physiological because of:-
Juma
cholesterol and triglycerides in simplest terms are fats (lipid) found in blood
Roy Reply
calcium is important for bone density and development. it also helps for safe / normal blood clotting, blood circulation to and from the heart, and muscle movement
Roy
please undertand me action potential ?
Josoph
minimum potential that must be overcomed to cause polarization and stimulate a neuronal response( generate impulse)
Ayodeji
what is muscle tissue
Rifat Reply
the muscle tissue is one of the 4 basic tissues in our body and is responsible for movement of our body
What Is difference between Ovary and Ovum
Sawda
ovary is female reproductive organ while ovum is a female gamete formed from ovary
Ubaidah
Thank You
Sawda
What Is Cholesterol and Triglycerides
Sawda
the mineral salt which break up a large portion of bone tissue
Aurora
in simple way muscle tissue is responsible for movement of our body.
Wellington
Hi Be Home Be safe , how are things doing hope all is well
Natarajan Reply
3 longitudinal bands of smooth muscles found in large intestines
Jamia

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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