<< Chapter < Page Chapter >> Page >
By the end of this section, you will be able to:
  • Distinguish the histological differences between the renal cortex and medulla
  • Describe the structure of the filtration membrane
  • Identify the major structures and subdivisions of the renal corpuscles, renal tubules, and renal capillaries
  • Discuss the function of the peritubular capillaries and vasa recta
  • Identify the location of the juxtaglomerular apparatus and describe the cells that line it
  • Describe the histology of the proximal convoluted tubule, loop of Henle, distal convoluted tubule, and collecting ducts

The renal structures that conduct the essential work of the kidney cannot be seen by the naked eye. Only a light or electron microscope can reveal these structures. Even then, serial sections and computer reconstruction are necessary to give us a comprehensive view of the functional anatomy of the nephron and its associated blood vessels.

Nephrons: the functional unit

Nephrons take a simple filtrate of the blood and modify it into urine. Many changes take place in the different parts of the nephron before urine is created for disposal. The term forming urine    will be used hereafter to describe the filtrate as it is modified into true urine. The principle task of the nephron population is to balance the plasma to homeostatic set points and excrete potential toxins in the urine. They do this by accomplishing three principle functions—filtration, reabsorption, and secretion. They also have additional secondary functions that exert control in three areas: blood pressure (via production of renin    ), red blood cell production (via the hormone EPO), and calcium absorption (via conversion of calcidiol into calcitriol, the active form of vitamin D).

Renal corpuscle

As discussed earlier, the renal corpuscle consists of a tuft of capillaries called the glomerulus that is largely surrounded by Bowman’s (glomerular) capsule. The glomerulus is a high-pressure capillary bed between afferent and efferent arterioles. Bowman’s capsule surrounds the glomerulus to form a lumen, and captures and directs this filtrate to the PCT. The outermost part of Bowman’s capsule, the parietal layer, is a simple squamous epithelium. It transitions onto the glomerular capillaries in an intimate embrace to form the visceral layer of the capsule. Here, the cells are not squamous, but uniquely shaped cells ( podocytes    ) extending finger-like arms ( pedicels    ) to cover the glomerular capillaries ( [link] ). These projections interdigitate to form filtration slits    , leaving small gaps between the digits to form a sieve. As blood passes through the glomerulus, 10 to 20 percent of the plasma filters between these sieve-like fingers to be captured by Bowman’s capsule and funneled to the PCT. Where the fenestrae (windows) in the glomerular capillaries match the spaces between the podocyte “fingers,” the only thing separating the capillary lumen and the lumen of Bowman’s capsule is their shared basement membrane ( [link] ). These three features comprise what is known as the filtration membrane. This membrane permits very rapid movement of filtrate from capillary to capsule though pores that are only 70 nm in diameter.

Questions & Answers

why when sex of an individual is determined by y chromosome found in male therefore why there is many women than male
pamfili Reply
I'm not sure if I fully understand your question.
are you sure it is more
samir
i don't remember what I said.
I'm not sure if I fully understand your question.
roughly taking a lead.
samir
Muscle of mastication
JIMOH Reply
difference between seminiferous tubules and ejaculatory duct
Muhammad Reply
tell me the answer boss
Musibi
wats dis group
Kity
hhhhhhhxhxhmxkoshzhdvxznbxhhsklskhdhdh
Agemo Reply
what is azygous vein
Karan Reply
Sir muscle contraction ka topic kis part m milega
sonugora Reply
Sir muscle contraction ka topic kis part m milega
sonugora Reply
what is manipulated
Ambika Reply
life circle of RBC and the life circle of WBC.
Yemi Reply
RBC 120days
Zeph
RBC 120days and WBC 10-12days
sai
what is cardiac vascular system
Hari
what is anatomy?
Md Reply
what is manipulated
Ambika
anatomy is the branch of medical science which deal with the gross structure of body or organ
Ambika
note shoulder joint
jagadeesh
what is cardiovascular system
Hari
what is manipulated
Ambika
anatomical position
Ambika
?
Ambika
Scapula
sonugora
Study of internal structures
sonugora
the system of heart and vessels
Manar
what is collar Bone?
jagadeesh
positive feedback mechanism
Sirimala Reply
what is immunology
Riya Reply
immunology is a branch of medicine that study's the body immune system
SAMUEL
Immunology This is the study of specific and non-specific resistance of the body against infection i.e. the study of the immune response of a host to a foreign substance, which includes study of various reactions which are induced in the body by introduction of a substance.
Kaluki
what is role of elimination need like fluid and also stools
Munmun Reply
bone
Vijay
what is joint pain
Vijay
is the physical suffering caused by illness or injury of the joint
malulu
pls can someone describe shock,types ,pathophysiology and treatment
Isaac
this is what I'm thinking "After taking out everything the body needs, the bowel then expels the leftover waste."
isaiah
I think elimination also helps in the continuation of the digestive system because if the unwanted fluids and stools does not come out of the system it can create a problem in the digestive. system resulting in diseases.
Martha
shock is a condition whereby the circulating system is unable to get enough blood and oxygen to vital organs like the brain,heart,eye,kidney and others.
Martha
causing depression of those organs.
Martha
there are 2 classification of shock. primary shock: this occurs immediately after injury due emotional stimulus or pain.example hearing a bad news,sudden obstruction of airway.sudden heart attack. secondary shock :it occurs when primary shock is delayed
Martha
types of shock syncope (faint) oligaemic or hyppvovaemic shock. Anaphylactic shock. neurogenic/ physical shock septic sock catdiogenic shock.
Martha
What is the difference between dna duplication and chromosomes duplication?
to help you identify the human body parts to help you live a healthy life the study of Anatomy helps one to work in any health sector
sophia Reply
okay.

Get the best Anatomy & Physiology course in your pocket!





Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
Google Play and the Google Play logo are trademarks of Google Inc.

Notification Switch

Would you like to follow the 'Anatomy & Physiology' conversation and receive update notifications?

Ask
Eric Crawford
Start Quiz