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Then by substituting Pouseille’s equation for blood flow:

Resistance = 8ηλ πr 4 MathType@MTEF@5@5@+=feaagyart1ev2aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLnhiov2DGi1BTfMBaeXatLxBI9gBaerbd9wDYLwzYbItLDharqqtubsr4rNCHbGeaGqiVu0Je9sqqrpepC0xbbL8F4rqqrFfpeea0xe9Lq=Jc9vqaqpepm0xbba9pwe9Q8fs0=yqaqpepae9pg0FirpepeKkFr0xfr=xfr=xb9adbaqaaeGaciGaaiaabeqaamaabaabaaGcbaGaaeOuaiaabwgacaqGZbGaaeyAaiaabohacaqG0bGaaeyyaiaab6gacaqGJbGaaeyzaiaabccacaqG9aWaaSaaaeaacaqG4aGaae4TdiaabU7aaeaacaqGapGaaeOCamaaCaaaleqabaGaaeinaaaaaaaaaa@46ED@

By examining this equation, you can see that there are only three variables: viscosity, vessel length, and radius, since 8 and π are both constants. The important thing to remember is this: Two of these variables, viscosity and vessel length, will change slowly in the body. Only one of these factors, the radius, can be changed rapidly by vasoconstriction and vasodilation, thus dramatically impacting resistance and flow. Further, small changes in the radius will greatly affect flow, since it is raised to the fourth power in the equation.

We have briefly considered how cardiac output and blood volume impact blood flow and pressure; the next step is to see how the other variables (contraction, vessel length, and viscosity) articulate with Pouseille’s equation and what they can teach us about the impact on blood flow.

Blood volume

The relationship between blood volume, blood pressure, and blood flow is intuitively obvious. Water may merely trickle along a creek bed in a dry season, but rush quickly and under great pressure after a heavy rain. Similarly, as blood volume decreases, pressure and flow decrease. As blood volume increases, pressure and flow increase.

Under normal circumstances, blood volume varies little. Low blood volume, called hypovolemia    , may be caused by bleeding, dehydration, vomiting, severe burns, or some medications used to treat hypertension. It is important to recognize that other regulatory mechanisms in the body are so effective at maintaining blood pressure that an individual may be asymptomatic until 10–20 percent of the blood volume has been lost. Treatment typically includes intravenous fluid replacement.

Hypervolemia , excessive fluid volume, may be caused by retention of water and sodium, as seen in patients with heart failure, liver cirrhosis, some forms of kidney disease, hyperaldosteronism, and some glucocorticoid steroid treatments. Restoring homeostasis in these patients depends upon reversing the condition that triggered the hypervolemia.

Blood viscosity

Viscosity is the thickness of fluids that affects their ability to flow. Clean water, for example, is less viscous than mud. The viscosity of blood is directly proportional to resistance and inversely proportional to flow; therefore, any condition that causes viscosity to increase will also increase resistance and decrease flow. For example, imagine sipping milk, then a milkshake, through the same size straw. You experience more resistance and therefore less flow from the milkshake. Conversely, any condition that causes viscosity to decrease (such as when the milkshake melts) will decrease resistance and increase flow.

Normally the viscosity of blood does not change over short periods of time. The two primary determinants of blood viscosity are the formed elements and plasma proteins. Since the vast majority of formed elements are erythrocytes, any condition affecting erythropoiesis, such as polycythemia or anemia, can alter viscosity. Since most plasma proteins are produced by the liver, any condition affecting liver function can also change the viscosity slightly and therefore decrease blood flow. Liver abnormalities include hepatitis, cirrhosis, alcohol damage, and drug toxicities. While leukocytes and platelets are normally a small component of the formed elements, there are some rare conditions in which severe overproduction can impact viscosity as well.

Questions & Answers

list types epithelial tissue
Sangu Reply
explain how hormonal control aids in homeostasis regarding fluids and electrolytes, internal organs, clinical application, edema electrolyte imbalance?
Hensheal Reply
someone to help me explain those
parathyroid hormone : Calcium uptake, H+ and PO-4 wasting thyroid hormone, cortisol for temperature regulation by acting on B.V
also renin
why retro abdominal region called flank?
it is just Anatomical terminology
meaning side of body b/w rib cage and hip bone
list down all the hormones secreted by adrenal gland
Odong Reply
adrenaline hormones
The amount of blood pumped by the left ventricle of the heart in one contraction.
Javid Reply
how we can calculate the cardiac output
and how do we calculate the strock valume
stroke volume is not all the blood contained in the left ventricle; normally, only about two-thirds of the blood in the ventricle is expelled with each beat.
Cardiac output 5.5 l S. V 68.75 ml H. R 80bpm
If we consider SV 70, end systolic vol is about 15% of total(approx always) out of a total of 80-85 ml only 70ml is pumped per systole
what is macrophages?and its function
Sajjad Reply
macrophages they are white blood cells that engulf dead cells in the body
what is power stroke?
no idea
what is the stroke volume of heart?
If an autoimmune disorder targets the alpha cells, production of which hormone would be directly affected?
Samantha Reply
what is a muscle?
Gideon Reply
A band or bundle of fibrous tissue in a human or animal body that has the ability to contract, producing movement in or maintaining the position of parts of the body
what's endolphthamities and panophthalmities?
fluid around the brain
louise Reply
what ?
cerebro spinal fluid
The brain and spinal cord are surrounded by a clear fluid called cerebrospinal fluid (CSF). This fluid is produced and stored in cavities in the brain called ventricles. It circulatesaround the brain, moving from ventricle to ventricle. ... Hydrocephalus is a condition in which there is too much CSF
what is hydrocphalus
aminul Reply
Google krlena na madarchod yha maa chudwa rha ha sabko notification bhjke
when cerebrospinal fluid produce în the brain, i.e. brain ventricles, is to abundent in the brain and is not trăind out of the brain. as a consequence this lichid pute mechanical pressure oñ the brain and it pushes the cerebrum tissue. as a consequence this pressure on the neuronscan cause neurologi
cal disfunctions, for example clinical headache
. It is posible to drainout the fluid through a device dalles shunt,as i remember.
but where are also home medicinsfor decreasing the production of cerebrospin.fluid etc
there are some medicines that can decrease the production of csf
a neurologist advice is needed
i wrote some medicines NOT home medicines. it is a serious condition and specialized medical advice is needed. of course also general medical knowledge may be helpful, but not enough, a specialist is neede
if anyone help me in physiology
Radika Reply
i am BSN student of first year which book is best for physiology
i am BSN student of first year which book is best for physiology
ross and wilson anotomy and physiology
it's 1 book for anotomy and physiology it's best for bs nursing
yes Ross and wilson physiology is better for study
I'm also the student of bs nursing
I study guiton and hall &ganong
I'm also midwif help me be the best book for midwif
what ia the function of indocrine system
salam all friend
help me with this question; explain at least five emergency acute pain found in fundamental emergency medicine
Fascial compartment of forearm
what's a tissue?
Mwape Reply
a group of cells with the same function
tissue is a group of cells that perform the same functions.
explain a bit about a tissue
A tissue is made up of cells that are similar in shape and perform the same function, for instance brain cells form up a brain tissue. Whereas a group of tissues that perform the same function form an organ... so in this case the brain which is the organ is formed as a result of brain tissues.
what is gross anatomy
the branch of anatomy that deals with the structure of organs and tissues that are visible to the naked eye.
1.To know how the structures functions. 2.To easily identify the micro structures and the macro structures. 3.To be able to explain that anatomy is the study of the structures and physiology is the study of how the structures functions
Abban Reply
Describe the two classes of hormones (3 with subclasses) and how they affect their target cells.
Shalaeha Reply
what is control centre
Gohil Reply
Angie The larger air passage of the lung is
Angie Reply

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