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Card 12 / 21:
Why might topical, cosmetic application of atropine or scopolamine from the belladonna plant not cause fatal poisoning, as would occur with ingestion of the plant?
Drops of these substances into the eyes, as was once done cosmetically, blocks the muscarinic receptors in the smooth muscle of the iris. The concentration of this direct application is probably below the concentration that would cause poisoning if it got into the bloodstream. The possibility of that concentration being wrong and causing poisoning is too great, however, for atropine to be used as a cosmetic.
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